Ya-Ru Xu1, Li Liu1, Xiu-Hong Ren1, Ping-Ping Liu1, Hao Zhang1, Li Zheng1, Song-Song Zhang1, Li-Qiang Zhou2, Zhen-Xing Guo3. 1. Department of Hematology/Oncology，The First Hospital of Tsinghua University，Beijing 100016，China. 2. Department of Medical Oncology，Cancer Hospital of Chinese Academy of Medical Sciences，Beijing 100021，China.E-mail:zhouliqiang_bj@163.com. 3. Department of Hematology/Oncology，The First Hospital of Tsinghua University，Beijing 100016，China.E-mail: gzx2962@outlook.com.
Abstract
OBJECTIVE: To investigate the clinical outcome of the patients with primary diffuse large B-cell lymphoma（DLBCL）. METHODS: Clinical data of 148 patients with DLBCL in our hospital and cancer hospital from March 2006 to April 2016 were retrospectively analyzed. Kaplan-Meier analysis was used to estimate progression-free survival（PFS）and overall survival（OS）. RESULTS: 5-year OS and PFS rates were 85% and 69%，respectively. The survival analysis showed that 5-year OS rate of R-CHOP group was significantly higher than that of CHOP alone group（89% vs. 70%，P<0.05）. In univariate analysis，several clinical factors，such as older age（>60 years），poor ECOG score（≥2），advanced stage（Ⅲ-Ⅳ），higher IPI score（≥3），CHOP alone and absence of radiotherapy related with poor survival rate. Furthermore，multivariate analysis showed that age>60 year significantly related with the worse OS. CONCLUSION: Age >60 year is an important independent prognostic factor to predict worse OS or PFS.
OBJECTIVE: To investigate the clinical outcome of the patients with primary diffuse large B-cell lymphoma（DLBCL）. METHODS: Clinical data of 148 patients with DLBCL in our hospital and cancer hospital from March 2006 to April 2016 were retrospectively analyzed. Kaplan-Meier analysis was used to estimate progression-free survival（PFS）and overall survival（OS）. RESULTS: 5-year OS and PFS rates were 85% and 69%，respectively. The survival analysis showed that 5-year OS rate of R-CHOP group was significantly higher than that of CHOP alone group（89% vs. 70%，P<0.05）. In univariate analysis，several clinical factors，such as older age（>60 years），poor ECOG score（≥2），advanced stage（Ⅲ-Ⅳ），higher IPI score（≥3），CHOP alone and absence of radiotherapy related with poor survival rate. Furthermore，multivariate analysis showed that age>60 year significantly related with the worse OS. CONCLUSION: Age >60 year is an important independent prognostic factor to predict worse OS or PFS.