Literature DB >> 30737454

GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin-resistant S. aureus.

Xin Qi1, Xiaoqian Li1, Jianyuan Zhao1, Ning He1, Yihong Li1, Tao Zhang1, Shanshan Wang1, Liyan Yu2, Yunying Xie3.   

Abstract

Five alkaloid compounds (1-5), including one new compound, GKK1032C (1), and four known compounds, pyrrospirones E (2) and F (3), and GKK1032B (4) and A2 (5) were isolated from the culture of endophytic fungus Penicillium sp. CPCC 400817. The planar structures of all compounds were elucidated by NMR and MS spectra. The relative configuration of new compound GKK1032C (1) was deduced from the vicinal J-values and ROESY spectral data. Compound 1 exhibited potent antibacterial activity against methicillin-resistant Staphylococcus aureus with an MIC value of 1.6 μg ml-1.

Entities:  

Mesh：

Substances：

Year:  2019        PMID： 30737454     DOI： 10.1038/s41429-019-0144-5

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  7 in total

Review 1.  Endophytic Penicillium species and their agricultural, biotechnological, and pharmaceutical applications.

Authors:  Rufin Marie Kouipou Toghueo; Fabrice Fekam Boyom
Journal:  3 Biotech       Date:  2020-02-08       Impact factor: 2.406

2.  Diversity and Ginsenoside Biotransformation Potential of Cultivable Endophytic Fungi Associated With Panax bipinnatifidus var. bipinnatifidus in Qinling Mountains, China.

Authors:  Chao An; Saijian Ma; Xinwei Shi; Chen Liu; Hao Ding; Wenjiao Xue
Journal:  Front Pharmacol       Date:  2022-04-04       Impact factor: 5.988

Review 3.  The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms.

Authors:  Minghua Jiang; Senhua Chen; Jing Li; Lan Liu
Journal:  Mar Drugs       Date:  2020-02-15       Impact factor: 5.118

4.  Tricarbocyclic core formation of tyrosine-decahydrofluorenes implies a three-enzyme cascade with XenF-mediated sigmatropic rearrangement as a prerequisite.

Authors:  Zhiguo Liu; Wei Li; Peng Zhang; Jie Fan; Fangbo Zhang; Caixia Wang; Shuming Li; Yi Sun; Shilin Chen; Wenbing Yin
Journal:  Acta Pharm Sin B       Date:  2021-03-26       Impact factor: 11.413

5.  Bioactive PKS-NRPS Alkaloids from the Plant-Derived Endophytic Fungus Xylaria arbuscula.

Authors:  Ya Wang; Sinan Zhao; Tao Guo; Li Li; Tantan Li; Anqi Wang; Dandan Zhang; Yanlei Wang; Yi Sun
Journal:  Molecules       Date:  2021-12-27       Impact factor: 4.411

6.  Didymellanosine, a new decahydrofluorene analogue, and ascolactone C from Didymella sp. IEA-3B.1, an endophyte of Terminalia catappa.

Authors:  Ni P Ariantari; Elena Ancheeva; Marian Frank; Fabian Stuhldreier; Dieter Meier; Yvonne Gröner; Irene Reimche; Nicole Teusch; Sebastian Wesselborg; Werner E G Müller; Rainer Kalscheuer; Zhen Liu; Peter Proksch
Journal:  RSC Adv       Date:  2020-02-18       Impact factor: 4.036

7.  Metabolic and pharmacological profiling of Penicillium claviforme by a combination of experimental and bioinformatic approaches.

Authors:  Zafar Ali Shah; Khalid Khan; Zafar Iqbal; Tariq Masood; Hassan A Hemeg; Abdur Rauf
Journal:  Ann Med       Date:  2022-12       Impact factor: 5.348
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.