Martin Laclaustra1, Fernando Rodriguez-Artalejo2, Pilar Guallar-Castillon2, Jose R Banegas3, Auxiliadora Graciani3, Esther Garcia-Esquinas3, Esther Lopez-Garcia2. 1. Instituto de Investigación Sanitaria de Aragón (IIS Aragón), CIBERCV, Agencia Aragonesa para la Investigación y el Desarrollo (ARAID), Translational Research Unit, Hospital Universitario Miguel Servet, Paseo Isabel la Católica, 1-3, 50009, Zaragoza, Spain; CIBERESP and Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid/Idipaz, Arzobispo Morcillo, 4, 28029, Madrid, Spain. Electronic address: martin.laclaustra@unizar.es. 2. CIBERESP and Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid/Idipaz, Arzobispo Morcillo, 4, 28029, Madrid, Spain; IMDEA-Food Institute, CEI UAM+CSIC, Madrid, Spain. 3. CIBERESP and Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid/Idipaz, Arzobispo Morcillo, 4, 28029, Madrid, Spain.
Abstract
BACKGROUND: Certain foods and dietary patterns have been associated with both inflammation and frailty. As chronic inflammation may play a role in frailty and disability, we examined the association of the inflammatory potential of diet with these outcomes. METHODS: Data were taken from 1948 community-dwelling individuals ≥60 years old from the Seniors-ENRICA cohort, who were recruited in 2008-2010 and followed-up through 2012. Baseline diet data, obtained with a validated diet history, was used to calculate Shivappa's Dietary Inflammatory Index (DII), an "a priori" pattern score which is based on known associations of foods and nutrients with inflammation, and Tabung's Empirical Dietary Inflammatory Index (EDII), an "a posteriori" pattern score which was statistically derived from an epidemiological study. At follow-up, incident frailty was assessed with Fried's criteria, and incident limitation in instrumental activities of daily living (IADL) with the Lawton-Brody index. Statistical analyses were performed with logistic regression, and adjusted for the main confounders. RESULTS: Compared with individuals in the lowest tertile of DII, those in the highest tertile showed higher risk of frailty (odds ratio [OR] 2.48; 95% confidence interval [CI]: 1.42, 4.44, p-trend = 0.001) and IADL disability (OR: 1.96; 95% CI: 1.03, 3.86, p-trend = 0.035). By contrast, EDII did not show an association with these outcomes. The DII score was associated with slow gait speed, both as a low score in the Short Physical Performance Battery test (OR: 1.82; 95% CI: 1.27, 2.62, p-trend = 0.001) and as a positive Fried's criterion (OR: 1.64; 95% CI: 1.08, 2.51, p-trend = 0.021), which use different thresholds. CONCLUSIONS: DII predicted frailty and IADL while EDII did not. DII is able to measure diet healthiness in terms of physical decline in addition to avoidance of inflammation. REGISTERED ON: ClinicalTrials.gov number, NCT01133093.
BACKGROUND: Certain foods and dietary patterns have been associated with both inflammation and frailty. As chronic inflammation may play a role in frailty and disability, we examined the association of the inflammatory potential of diet with these outcomes. METHODS: Data were taken from 1948 community-dwelling individuals ≥60 years old from the Seniors-ENRICA cohort, who were recruited in 2008-2010 and followed-up through 2012. Baseline diet data, obtained with a validated diet history, was used to calculate Shivappa's Dietary Inflammatory Index (DII), an "a priori" pattern score which is based on known associations of foods and nutrients with inflammation, and Tabung's Empirical Dietary Inflammatory Index (EDII), an "a posteriori" pattern score which was statistically derived from an epidemiological study. At follow-up, incident frailty was assessed with Fried's criteria, and incident limitation in instrumental activities of daily living (IADL) with the Lawton-Brody index. Statistical analyses were performed with logistic regression, and adjusted for the main confounders. RESULTS: Compared with individuals in the lowest tertile of DII, those in the highest tertile showed higher risk of frailty (odds ratio [OR] 2.48; 95% confidence interval [CI]: 1.42, 4.44, p-trend = 0.001) and IADL disability (OR: 1.96; 95% CI: 1.03, 3.86, p-trend = 0.035). By contrast, EDII did not show an association with these outcomes. The DII score was associated with slow gait speed, both as a low score in the Short Physical Performance Battery test (OR: 1.82; 95% CI: 1.27, 2.62, p-trend = 0.001) and as a positive Fried's criterion (OR: 1.64; 95% CI: 1.08, 2.51, p-trend = 0.021), which use different thresholds. CONCLUSIONS: DII predicted frailty and IADL while EDII did not. DII is able to measure diet healthiness in terms of physical decline in addition to avoidance of inflammation. REGISTERED ON: ClinicalTrials.gov number, NCT01133093.
Authors: Courtney L Millar; Alyssa B Dufour; Nitin Shivappa; Daniel Habtemariam; Joanne M Murabito; Emelia J Benjamin; James R Hebert; Douglas P Kiel; Marian T Hannan; Shivani Sahni Journal: Am J Clin Nutr Date: 2022-02-09 Impact factor: 8.472
Authors: Marlene Gojanovic; Kara L Holloway-Kew; Natalie K Hyde; Mohammadreza Mohebbi; Nitin Shivappa; James R Hebert; Adrienne O'Neil; Julie A Pasco Journal: Nutrients Date: 2021-04-01 Impact factor: 5.717
Authors: Mary Ni Lochlainn; Natalie J Cox; Thomas Wilson; Richard P G Hayhoe; Sheena E Ramsay; Antoneta Granic; Masoud Isanejad; Helen C Roberts; Daisy Wilson; Carly Welch; Christopher Hurst; Janice L Atkins; Nuno Mendonça; Katy Horner; Esme R Tuttiett; Yvie Morgan; Phil Heslop; Elizabeth A Williams; Claire J Steves; Carolyn Greig; John Draper; Clare A Corish; Ailsa Welch; Miles D Witham; Avan A Sayer; Sian Robinson Journal: Nutrients Date: 2021-07-09 Impact factor: 5.717