R Negaresh1, R W Motl2, P Zimmer3,4, M Mokhtarzade1, J S Baker5. 1. Department of Physical Education and Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran. 2. Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL, USA. 3. Department for Molecular and Cellular Sports Medicine, German Sport University Cologne, Cologne. 4. Division of Physical Activity, Prevention and Cancer, German Cancer Research Center, Heidelberg, Germany. 5. Applied Physiology Research Laboratory, School of Health and Life Sciences, University of the West of Scotland, Lanarkshire Campus, Paisley, UK.
Abstract
BACKGROUND AND PURPOSE: Multiple sclerosis (MS) is a demyelinating and neurodegenerative disease of the central nervous system (CNS) that can be tracked through biomarkers of disease status. We investigated the effects of exercise on MS biomarkers associated with CNS status including imaging, blood-brain barrier (BBB) function and neurotrophic factors. METHODS: We conducted open-dated searches of Scopus, Medline, EMBASE and the Cochrane Library. We included studies written in English describing interventions of exercise that measured one or more of the biomarkers associated with MS published up to October 2018. RESULTS: We located a total of 3012 citations through searches in electronic databases. Of these, 16 studies were eligible for review; six studies focused on magnetic resonance imaging (MRI) markers, nine studies focused on neurotrophic factors and three studies focused on BBB function markers. It is of note that two studies included both neurotrophic factor and BBB function markers and are therefore included across categories of biomarkers in this review. The existing evidence from MRI studies confirmed that exercise training can improve CNS integrity and function. There is evidence of a positive effect of exercise training on modulation of BBB permeability markers and brain-derived neurotrophic factor. CONCLUSIONS: Exercise successfully improves MRI outcomes and peripheral biomarkers (i.e. brain-derived neurotrophic factor) in people with MS. This suggests that exercise can be recommended as an adjuvant therapy for MS treatment. This conclusion is tempered by some methodological limitations including small sample sizes and high drop-out rates in the reviewed studies.
BACKGROUND AND PURPOSE:Multiple sclerosis (MS) is a demyelinating and neurodegenerative disease of the central nervous system (CNS) that can be tracked through biomarkers of disease status. We investigated the effects of exercise on MS biomarkers associated with CNS status including imaging, blood-brain barrier (BBB) function and neurotrophic factors. METHODS: We conducted open-dated searches of Scopus, Medline, EMBASE and the Cochrane Library. We included studies written in English describing interventions of exercise that measured one or more of the biomarkers associated with MS published up to October 2018. RESULTS: We located a total of 3012 citations through searches in electronic databases. Of these, 16 studies were eligible for review; six studies focused on magnetic resonance imaging (MRI) markers, nine studies focused on neurotrophic factors and three studies focused on BBB function markers. It is of note that two studies included both neurotrophic factor and BBB function markers and are therefore included across categories of biomarkers in this review. The existing evidence from MRI studies confirmed that exercise training can improve CNS integrity and function. There is evidence of a positive effect of exercise training on modulation of BBB permeability markers and brain-derived neurotrophic factor. CONCLUSIONS: Exercise successfully improves MRI outcomes and peripheral biomarkers (i.e. brain-derived neurotrophic factor) in people with MS. This suggests that exercise can be recommended as an adjuvant therapy for MS treatment. This conclusion is tempered by some methodological limitations including small sample sizes and high drop-out rates in the reviewed studies.
Authors: Y Kutsenko; A Barreda; A Toval; D Garrigos; M Martínez-Morga; B Ribeiro Do Couto; J L Ferran Journal: Sci Rep Date: 2021-05-12 Impact factor: 4.379
Authors: Sebastian Proschinger; Niklas Joisten; Annette Rademacher; Marit L Schlagheck; David Walzik; Alan J Metcalfe; Max Oberste; Clemens Warnke; Wilhelm Bloch; Alexander Schenk; Jens Bansi; Philipp Zimmer Journal: BMC Neurol Date: 2019-12-06 Impact factor: 2.474
Authors: Eya Torkhani; Emilie Dematte; Jean Slawinski; Antonia Csillik; Marie-Claire Gay; Djamel Bensmaïl; Olivier Heinzlef; Giovanni de Marco Journal: Front Psychol Date: 2021-12-24
Authors: Marit L Schlagheck; Niklas Joisten; Annette Rademacher; Philipp Zimmer; David Walzik; Florian Wolf; Sarah E Neil-Sztramko; Jens Bansi Journal: Neurol Ther Date: 2021-09-14
Authors: Augustine J Devasahayam; Arthur R Chaves; Wendy O Lasisi; Marie E Curtis; Katie P Wadden; Liam P Kelly; Ryan Pretty; Alice Chen; Elizabeth M Wallack; Caitlin J Newell; John B Williams; Hannah Kenny; Matthew B Downer; Jason McCarthy; Craig S Moore; Michelle Ploughman Journal: BMC Neurol Date: 2020-01-22 Impact factor: 2.474