Stefanie Metzler1,2, Remo Frei2,3, Elisabeth Schmaußer-Hechfellner4, Erika von Mutius4,5,6, Juha Pekkanen7,8, Anne M Karvonen7, Pirkka V Kirjavainen7, Jean-Charles Dalphin9, Amandine Divaret-Chauveau10,11,12, Josef Riedler13,14, Roger Lauener2,15, Caroline Roduit2,15,16. 1. University of Zurich, Zurich, Switzerland. 2. Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland. 3. Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland. 4. Helmholtz Zentrum München - German Research Center for Environmental Health, Institute for Asthma and Allergy Prevention, Neuherberg, Germany. 5. Dr von Hauner Children's Hospital, Ludwig Maximilian University, Munich, Germany. 6. CPC-M, German Center for Lung Research, Munich, Germany. 7. Environment Health Unit, National Institute for Health and Welfare, Kuopio, Finland. 8. Department of Public Health, University of Helsinki, Helsinki, Finland. 9. Department of Respiratory Disease, UMR/CNRS 6249 Chrono-environment, University Hospital, University of Besançon, Besançon, France. 10. Pediatric Allergy Department, University Hospital of Nancy, Nancy, France. 11. EA3450 Développement Adaptation et Handicap (DevAH), University of Lorraine, Nancy, France. 12. UMR 6249 Chrono-environment, CNRS and University of Franche-Comté, Besançon, France. 13. Children's Hospital Schwarzach, Schwarzach, Austria. 14. Teaching Hospital of Paracelsus Medical Private University Salzburg, Salzburg, Austria. 15. Children's Hospital St Gallen, St Gallen, Switzerland. 16. University Children's Hospital Zurich, Zurich, Switzerland.
Abstract
BACKGROUND: Allergies are a serious public health issue, and prevalences are rising worldwide. The role of antibiotics in the development of allergies has repeatedly been discussed, as results remain inconsistent. The aim of this study was to investigate the association between pre- and post-natal antibiotic exposure and subsequent development of allergies (atopic dermatitis, food allergy, asthma, atopic sensitization and allergic rhinitis). METHODS: A total of 1080 children who participated in a European birth cohort study (PASTURE) were included in this analysis. Data on antibiotic exposure during pregnancy and/or first year of life and allergic diseases were collected by questionnaires from pregnancy up to 6 years of age and analysed by performing logistic regressions. To take into account reverse causation, we included models, where children with diagnosis or symptoms of the respective disease in the first year of life were excluded. RESULTS: Antibiotic exposure in utero was significantly and positively associated with atopic dermatitis and food allergy. The strongest effect was on diseases with onset within the first year of life (for atopic dermatitis: aOR 1.66, 95% CI 1.11-2.48 and for food allergy: aOR 3.01, 95% CI 1.22-7.47). Antibiotics in the first year of life were positively associated with atopic dermatitis up to 4 years (aOR 2.73, 95% CI 1.66-4.49) and also suggested a dose-response relationship. A tendency was observed with asthma between 3 and 6 years (aOR 1.65, 95% CI 0.95-2.86). CONCLUSIONS: Our findings show positive associations between exposure to antibiotics and allergies, mainly atopic dermatitis and food allergy within the first year of life, after prenatal exposure, and atopic dermatitis and asthma after post-natal exposure to antibiotics in children born in rural settings.
BACKGROUND:Allergies are a serious public health issue, and prevalences are rising worldwide. The role of antibiotics in the development of allergies has repeatedly been discussed, as results remain inconsistent. The aim of this study was to investigate the association between pre- and post-natal antibiotic exposure and subsequent development of allergies (atopic dermatitis, food allergy, asthma, atopic sensitization and allergic rhinitis). METHODS: A total of 1080 children who participated in a European birth cohort study (PASTURE) were included in this analysis. Data on antibiotic exposure during pregnancy and/or first year of life and allergic diseases were collected by questionnaires from pregnancy up to 6 years of age and analysed by performing logistic regressions. To take into account reverse causation, we included models, where children with diagnosis or symptoms of the respective disease in the first year of life were excluded. RESULTS: Antibiotic exposure in utero was significantly and positively associated with atopic dermatitis and food allergy. The strongest effect was on diseases with onset within the first year of life (for atopic dermatitis: aOR 1.66, 95% CI 1.11-2.48 and for food allergy: aOR 3.01, 95% CI 1.22-7.47). Antibiotics in the first year of life were positively associated with atopic dermatitis up to 4 years (aOR 2.73, 95% CI 1.66-4.49) and also suggested a dose-response relationship. A tendency was observed with asthma between 3 and 6 years (aOR 1.65, 95% CI 0.95-2.86). CONCLUSIONS: Our findings show positive associations between exposure to antibiotics and allergies, mainly atopic dermatitis and food allergy within the first year of life, after prenatal exposure, and atopic dermatitis and asthma after post-natal exposure to antibiotics in children born in rural settings.
Authors: Rodrigo Jiménez-Saiz; Varun C Anipindi; Heather Galipeau; Yosef Ellenbogen; Roopali Chaudhary; Joshua F Koenig; Melissa E Gordon; Tina D Walker; Talveer S Mandur; Soumeya Abed; Alison Humbles; Derek K Chu; Jonas Erjefält; Kjetil Ask; Elena F Verdú; Manel Jordana Journal: Front Immunol Date: 2020-02-13 Impact factor: 7.561
Authors: Matthias V Kopp; Cathleen Muche-Borowski; Michael Abou-Dakn; Birgit Ahrens; Kirsten Beyer; Katharina Blümchen; Petra Bubel; Adam Chaker; Monika Cremer; Regina Ensenauer; Michael Gerstlauer; Uwe Gieler; Inga-Marie Hübner; Fritz Horak; Ludger Klimek; Berthold V Koletzko; Sybille Koletzko; Susanne Lau; Thomas Lob-Corzilius; Katja Nemat; Eva M J Peters; Antonio Pizzulli; Imke Reese; Claudia Rolinck-Werninghaus; Elien Rouw; Bianca Schaub; Sebastian Schmidt; Jens-Oliver Steiß; Anne Kathrin Striegel; Zsolt Szépfalusi; Dietmar Schlembach; Thomas Spindler; Christian Taube; Valérie Trendelenburg; Regina Treudler; Ulrich Umpfenbach; Christian Vogelberg; Martin Wagenmann; Anke Weißenborn; Thomas Werfel; Margitta Worm; Helmut Sitter; Eckard Hamelmann Journal: Allergol Select Date: 2022-03-04