Diego Alves Vieira1,2, Luciana Rodrigues da Cunha1, Cliviany Borges da Silva1, Maria Thereza Bastos Almeida3, Adriana Dias Gomes4, César Lúcio Lopes de Faria4, Rosângela Teixeira1,5, Fernando Silva Neves2, Gifone Aguiar Rocha4, Fabrício Freire de Melo4, Dulciene Maria de Magalhães Queiroz4, Luciana Diniz Silva6,7. 1. Faculdade de Medicina, Outpatient Clinic of Viral Hepatitis, Instituto Alfa de Gastroenterologia, Universidade Federal de Minas Gerais (UFMG), Av Alfredo Balena 190 s/216, Belo Horizonte, Minas Gerais, 30130-100, Brazil. 2. Sciences Applied to Adult Health Care Post-Graduate Programme, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil. 3. Medical undergraduate student, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil. 4. Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil. 5. Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, 30130-100, Brazil. 6. Faculdade de Medicina, Outpatient Clinic of Viral Hepatitis, Instituto Alfa de Gastroenterologia, Universidade Federal de Minas Gerais (UFMG), Av Alfredo Balena 190 s/216, Belo Horizonte, Minas Gerais, 30130-100, Brazil. lucianadinizsilva@gmail.com. 7. Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, 30130-100, Brazil. lucianadinizsilva@gmail.com.
Abstract
PURPOSE: Chronic hepatitis C (CHC) is associated with a decreased health-related quality of life (HRQOL). More recent studies have pointed toward a genetic basis of patient-reported quality of life outcomes. Taking into account that the influence of single-nucleotide polymorphisms (SNPs) on the HRQOL of CHC patients has not been studied, we investigated the combined IL10-1082G/A, - 819C/T, and - 592C/A SNPs, and IL6-174G/C SNP. We also evaluated the association between demographic, clinical, psychiatric, virological, and genetic variables with domains and summaries of HRQOL in CHC patients. METHODS: 132 consecutive CHC patients and 98 controls underwent psychiatric evaluation by using the Mini International Neuropsychiatric Interview. HRQOL was assessed by a generic questionnaire, the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36), and by the specific Liver Disease Quality of Life Questionnaire (LDQOL). IL6 and IL10 polymorphisms were evaluated by Taqman SNP genotyping assay. Multivariate analysis was used to evaluate the associations. RESULTS: Major depressive disorder was associated with lower SF-36 and LDQOL scores in seven and ten domains, respectively. Diabetes and hypertension were also associated with reduced HRQOL. CHC patients carrying the combination of IL10 ATA haplotype/IL6-GG genotype had lower scores in the SF-36-physical functioning domain, and reduced scores in the LDQOL effects of liver disease on activities of daily living, quality of social interaction, and sexual function domains than the non-carriers of the combined haplotype/genotype. CONCLUSION: This is the first study to demonstrate that combined IL6 high-producer GG genotype and IL10 low-producer ATA haplotype is associated with poorer HRQOL in CHC patients.
PURPOSE:Chronic hepatitis C (CHC) is associated with a decreased health-related quality of life (HRQOL). More recent studies have pointed toward a genetic basis of patient-reported quality of life outcomes. Taking into account that the influence of single-nucleotide polymorphisms (SNPs) on the HRQOL of CHCpatients has not been studied, we investigated the combined IL10-1082G/A, - 819C/T, and - 592C/A SNPs, and IL6-174G/C SNP. We also evaluated the association between demographic, clinical, psychiatric, virological, and genetic variables with domains and summaries of HRQOL in CHCpatients. METHODS: 132 consecutive CHCpatients and 98 controls underwent psychiatric evaluation by using the Mini International Neuropsychiatric Interview. HRQOL was assessed by a generic questionnaire, the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36), and by the specific Liver Disease Quality of Life Questionnaire (LDQOL). IL6 and IL10 polymorphisms were evaluated by Taqman SNP genotyping assay. Multivariate analysis was used to evaluate the associations. RESULTS: Major depressive disorder was associated with lower SF-36 and LDQOL scores in seven and ten domains, respectively. Diabetes and hypertension were also associated with reduced HRQOL. CHCpatients carrying the combination of IL10 ATA haplotype/IL6-GG genotype had lower scores in the SF-36-physical functioning domain, and reduced scores in the LDQOL effects of liver disease on activities of daily living, quality of social interaction, and sexual function domains than the non-carriers of the combined haplotype/genotype. CONCLUSION: This is the first study to demonstrate that combined IL6 high-producer GG genotype and IL10 low-producer ATA haplotype is associated with poorer HRQOL in CHCpatients.
Authors: I M Gralnek; R D Hays; A Kilbourne; H R Rosen; E B Keeffe; L Artinian; S Kim; D Lazarovici; D M Jensen; R W Busuttil; P Martin Journal: Am J Gastroenterol Date: 2000-12 Impact factor: 10.864
Authors: G Marchesini; G Bianchi; P Amodio; F Salerno; M Merli; C Panella; C Loguercio; G Apolone; M Niero; R Abbiati Journal: Gastroenterology Date: 2001-01 Impact factor: 22.682
Authors: G Bianchi; G Marchesini; F Nicolino; R Graziani; D Sgarbi; C Loguercio; R Abbiati; M Zoli Journal: Dig Liver Dis Date: 2005-08 Impact factor: 4.088