Şerife Gül Karadağ1, Ayşe Tanatar1, Hafize Emine Sönmez1, Figen Çakmak1, Aysel Kıyak2, Sevgi Yavuz2, Mustafa Çakan1, Nuray Aktay Ayaz3. 1. Kanuni Sultan Süleyman Research and Training Hospital, Department of Pediatric Rheumatology, University of Health Science, No: 46/1, Kucukcekmece, 34303, Istanbul, Turkey. 2. Kanuni Sultan Süleyman Research and Training Hospital, Department of Pediatric Nephrology, University of Health Science, Istanbul, Turkey. 3. Kanuni Sultan Süleyman Research and Training Hospital, Department of Pediatric Rheumatology, University of Health Science, No: 46/1, Kucukcekmece, 34303, Istanbul, Turkey. nurayaktay@gmail.com.
Abstract
OBJECTIVES: Henoch-Schönlein purpura (HSP) is the most common vasculitis of children. The aim of this study is to evaluate the demographic and clinic findings of patients with HSP and also to determine predictive factors for assessing the development of gastrointestinal system (GIS) and renal involvement. METHODS: This study was performed prospectively among children with HSP who are under 18 years of age and being followed-up in the Pediatric Rheumatology Unit of Health Sciences University Kanuni Sultan Süleyman Training and Research Hospital between January 2016 and January 2018. RESULTS: A total of 265 patients, 137 boys (51.7%) and 128 girls (48.3%), were involved to the study. The mean ± standard deviation of age at the diagnosis was 7.5 ± 3.2. The most common disease onset season was spring (31.7%). The rate of arthritis, GIS involvement, and renal involvement were 54%, 51.3%, and 29.1%, respectively. GIS bleeding was more frequent in males than females (p = 0.007). Boys over 7 years of age had significantly more common GIS bleeding (p = 0.04). Intussusception, relapse, and serious GIS involvement requiring hospitalization and steroid treatment were highly associated with severe renal involvement. CONCLUSIONS: We demonstrated that patients suffering intussusception, relapse, and serious GIS involvement or requiring hospitalization and steroid treatment had tendency to present with severe renal involvement. Therefore, these patients should be followed up carefully for not overlooking renal involvement of HSP.
OBJECTIVES: Henoch-Schönlein purpura (HSP) is the most common vasculitis of children. The aim of this study is to evaluate the demographic and clinic findings of patients with HSP and also to determine predictive factors for assessing the development of gastrointestinal system (GIS) and renal involvement. METHODS: This study was performed prospectively among children with HSP who are under 18 years of age and being followed-up in the Pediatric Rheumatology Unit of Health Sciences University Kanuni Sultan Süleyman Training and Research Hospital between January 2016 and January 2018. RESULTS: A total of 265 patients, 137 boys (51.7%) and 128 girls (48.3%), were involved to the study. The mean ± standard deviation of age at the diagnosis was 7.5 ± 3.2. The most common disease onset season was spring (31.7%). The rate of arthritis, GIS involvement, and renal involvement were 54%, 51.3%, and 29.1%, respectively. GIS bleeding was more frequent in males than females (p = 0.007). Boys over 7 years of age had significantly more common GIS bleeding (p = 0.04). Intussusception, relapse, and serious GIS involvement requiring hospitalization and steroid treatment were highly associated with severe renal involvement. CONCLUSIONS: We demonstrated that patients suffering intussusception, relapse, and serious GIS involvement or requiring hospitalization and steroid treatment had tendency to present with severe renal involvement. Therefore, these patients should be followed up carefully for not overlooking renal involvement of HSP.
Authors: Samy A Dawood; Abdoh M Abodiah; Saleh M Alqahtani; Ayed A Shati; Youssef A Alqahtani; Mohammed A Alshehri; Syed E Mahmood Journal: Healthcare (Basel) Date: 2021-12-07