Self-assembly of a magnetic DNA hydrogel as a new biomaterial for enzyme encapsulation with enhanced activity and stability.

We provide a new strategy to construct a magnetic DNA hydrogel for enzyme encapsulation through a programmable one-pot self-assembly approach, which can be easily separated from the reaction medium. The encapsulated enzyme composites exhibited significantly improved enzymatic activity, stability, reusability and excellent selectivity for the detection of low concentrations of glucose.