Literature DB >> 30733652

Ethics of Adoption and Use of the Linear No-Threshold Model.

Moshe Yanovskiy1,2, Yair Y Shaki1, Yehoshua Socol1.   

Abstract

The linear no-threshold (LNT) model of ionizing radiation-induced cancer assumes that every increment of radiation dose, no matter how small, constitutes an increased cancer risk for humans. Linear no-threshold is presently the most widely applied model for radiation risk assessment. As such, it imposes very heavy burden on the society in both economic and human terms. This model, which was adopted in late 1950s in the wake of massive government investments in science, is controversial and raises important ethical issues. This article identifies 2 issues often missed: scientists usurping the role of policy makers and seeking funding and power. These issues should be considered together with the scientific controversy raging over the validity of the LNT model and the multiple other ethical issues regarding its ongoing use.

Entities:  

Keywords:  LNT dose–response model; conflict of interests; health and environmental protection regulations; ionizing radiation; nuclear safety; professional ethics

Year:  2019        PMID: 30733652      PMCID: PMC6343444          DOI: 10.1177/1559325818822602

Source DB:  PubMed          Journal:  Dose Response        ISSN: 1559-3258            Impact factor:   2.658


  9 in total

1.  Dose-effect relationship and estimation of the carcinogenic effects of low doses of ionizing radiation: the joint report of the Académie des Sciences (Paris) and of the Académie Nationale de Médecine.

Authors:  Maurice Tubiana
Journal:  Int J Radiat Oncol Biol Phys       Date:  2005-10-01       Impact factor: 7.038

Review 2.  The road to linearity: why linearity at low doses became the basis for carcinogen risk assessment.

Authors:  Edward J Calabrese
Journal:  Arch Toxicol       Date:  2009-02-27       Impact factor: 5.153

3.  ARTIFICIAL TRANSMUTATION OF THE GENE.

Authors:  H J Muller
Journal:  Science       Date:  1927-07-22       Impact factor: 47.728

Review 4.  The linear nonthreshold (LNT) model as used in radiation protection: an NCRP update.

Authors:  John D Boice
Journal:  Int J Radiat Biol       Date:  2017-06-14       Impact factor: 2.694

5.  Low-dose cancer risk modeling must recognize up-regulation of protection.

Authors:  Ludwig E Feinendegen; Myron Pollycove; Ronald D Neumann
Journal:  Dose Response       Date:  2009-12-10       Impact factor: 2.658

6.  Commentary: ethical issues of current health-protection policies on low-dose ionizing radiation.

Authors:  Yehoshua Socol; Ludwik Dobrzyński; Mohan Doss; Ludwig E Feinendegen; Marek K Janiak; Mark L Miller; Charles L Sanders; Bobby R Scott; Brant Ulsh; Alexander Vaiserman
Journal:  Dose Response       Date:  2013-11-07       Impact factor: 2.658

Review 7.  Was Muller's 1946 Nobel Prize research for radiation-induced gene mutations peer-reviewed?

Authors:  Edward J Calabrese
Journal:  Philos Ethics Humanit Med       Date:  2018-06-06       Impact factor: 2.464

8.  The EPA Cancer Risk Assessment Default Model Proposal: Moving Away From the LNT.

Authors:  Edward J Calabrese; Jaap C Hanekamp; Dima Yazji Shamoun
Journal:  Dose Response       Date:  2018-08-09       Impact factor: 2.658

9.  Regulating Ionizing Radiation Based on Metrics for Evaluation of Regulatory Science Claims.

Authors:  A Alan Moghissi; Richard Calderone; Furzan Azam; Teresa Nowak; Sarah Sheppard; Dennis K McBride; Lisa Jaeger
Journal:  Dose Response       Date:  2018-01-22       Impact factor: 2.658

  9 in total
  1 in total

1.  Until There Is a Resolution of the Pro-LNT/Anti-LNT Debate, We Should Head Toward a More Sensible Graded Approach for Protection From Low-Dose Ionizing Radiation.

Authors:  Pamela J Sykes
Journal:  Dose Response       Date:  2020-04-26       Impact factor: 2.658

  1 in total

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