Raquel Arroyo-Olivares1, Rodrigo Alonso1, Gracia Quintana-Navarro2, Francisco Fuentes-Jiménez2, Nelva Mata1, Ovidio Muñiz-Grijalvo3, José L Díaz-Díaz4, Daniel Zambón5, Francisco Arrieta6, Jesús García-Cruces1, Juan A Garrido-Sanjuan7, José R Banegas8, Pedro Mata1. 1. 1Fundación Hipercolesterolemia Familiar,C/General Álvarez de Castro 14,28010Madrid,Spain. 2. 3Lipids and Atherosclerosis Unit,IMIBIC,Hospital Universitario Reina Sofía,Córdoba,Spain. 3. 5Department of Internal Medicine,Hospital Virgen del Rocío,Seville,Spain. 4. 6Department of Internal Medicine,Hospital Abente y Lago,La Coruña,Spain. 5. 7Department of Endocrinology,Hospital Clínic,Barcelona,Spain. 6. 8Department of Endocrinology,Hospital Ramón y Cajal,Madrid,Spain. 7. 10Department of Internal Medicine,Complejo Hospitalario Universitario de Ferrol,La Coruña,Spain. 8. 11Department of Preventive Medicine and Public Health,Universidad Autónoma de Madrid/IdiPAZ and CIBER in Epidemiology and Public Health (CIBERESP),Madrid,Spain.
Abstract
OBJECTIVE: Healthy lifestyle habits are the cornerstone in the management of familial hypercholesterolaemia (FH). Nevertheless, dietary studies on FH-affected populations are scarce. The present study analyses dietary habits, adherence to a Mediterranean diet pattern and physical activity in an adult population with FH and compares them with their non-affected relatives. DESIGN: Cross-sectional study. SETTING: Data came from SAFEHEART, a nationwide study in Spain.ParticipantsIndividuals (n 3714) aged ≥18 years with a genetic diagnosis of FH (n2736) and their non-affected relatives (n 978). Food consumption was evaluated using a validated FFQ. RESULTS: Total energy intake was lower in FH patients v. non-affected relatives (P<0·005). Percentage of energy from fats was also lower in the FH population (35 % in men, 36 % in women) v. those non-affected (38 % in both sexes, P<0·005), due to the lower consumption of saturated fats (12·1 % in FH patients, 13·2 % in non-affected, P<0·005). Consumption of sugars was lower in FH patients v. non-affected relatives (P<0·05). Consumption of vegetables, fish and skimmed milk was higher in the FH population (P<0·005). Patients with FH showed greater adherence to a Mediterranean diet pattern v. non-affected relatives (P<0·005). Active smoking was lower and moderate physical activity was higher in people with FH, especially women (P<0·005). CONCLUSIONS: Adult patients with FH report healthier lifestyles than their non-affected family members. They eat a healthier diet, perform more physical activity and smoke less. However, this patient group's consumption of saturated fats and sugars still exceeds guidelines.
OBJECTIVE: Healthy lifestyle habits are the cornerstone in the management of familial hypercholesterolaemia (FH). Nevertheless, dietary studies on FH-affected populations are scarce. The present study analyses dietary habits, adherence to a Mediterranean diet pattern and physical activity in an adult population with FH and compares them with their non-affected relatives. DESIGN: Cross-sectional study. SETTING: Data came from SAFEHEART, a nationwide study in Spain.ParticipantsIndividuals (n 3714) aged ≥18 years with a genetic diagnosis of FH (n2736) and their non-affected relatives (n 978). Food consumption was evaluated using a validated FFQ. RESULTS: Total energy intake was lower in FHpatients v. non-affected relatives (P&lt;0·005). Percentage of energy from fats was also lower in the FH population (35 % in men, 36 % in women) v. those non-affected (38 % in both sexes, P&lt;0·005), due to the lower consumption of saturated fats (12·1 % in FHpatients, 13·2 % in non-affected, P&lt;0·005). Consumption of sugars was lower in FHpatients v. non-affected relatives (P&lt;0·05). Consumption of vegetables, fish and skimmed milk was higher in the FH population (P&lt;0·005). Patients with FH showed greater adherence to a Mediterranean diet pattern v. non-affected relatives (P&lt;0·005). Active smoking was lower and moderate physical activity was higher in people with FH, especially women (P&lt;0·005). CONCLUSIONS: Adult patients with FH report healthier lifestyles than their non-affected family members. They eat a healthier diet, perform more physical activity and smoke less. However, this patient group's consumption of saturated fats and sugars still exceeds guidelines.
Authors: Gerald F Watts; Samuel S Gidding; Pedro Mata; Jing Pang; David R Sullivan; Shizuya Yamashita; Frederick J Raal; Raul D Santos; Kausik K Ray Journal: Nat Rev Cardiol Date: 2020-01-23 Impact factor: 32.419
Authors: Henriette W Krogh; Karianne Svendsen; Jannicke Igland; Liv J Mundal; Kirsten B Holven; Martin P Bogsrud; Trond P Leren; Kjetil Retterstøl Journal: Sci Rep Date: 2019-12-17 Impact factor: 4.379