Duc Ha Hoang1, Anne Pagnier2, Emilie Cousin3, Karine Guichardet2, Isabelle Schiff2, Celine Icher4, Bixente Dilharreguy5, Jacques Grill6, Didier Frappaz7, Claire Berger8, Fabien Schneider9, Fanny Dubois-Teklali2, Alexandre Krainik10. 1. Grenoble institute of neurosciences, Inserm U836, 38000 Grenoble, France; University Grenoble Alps, 38000 Grenoble, France; Department of radiology, Viettiep university hospital, Haiphong, Viet Nam. 2. Department of pediatrics, Grenoble university hospital, 38000 Grenoble, France. 3. UMS IRMaGe, 38000 Grenoble, France; Laboratoratory of psychology and neurocognition, university Pierre-Mendès, 38000 Grenoble, France. 4. Department of pediatrics, Bordeaux university hospital, 38000 Bordeaux, France. 5. Institute of neuroscience, UMR 5287, 38000 Bordeaux, France. 6. Department of pediatrics, Gustave-Roussy institute, 38000 Villejuif, France. 7. Institute of pediatrics haematology and oncology, 38000 Lyon, France. 8. Department of pediatrics, Saint-Etienne university hospital, 38000 Saint-Étienne, France. 9. Department of neuroradiology, Saint-Etienne university hospital, 38000 Saint-Étienne, France. 10. Grenoble institute of neurosciences, Inserm U836, 38000 Grenoble, France; University Grenoble Alps, 38000 Grenoble, France; UMS IRMaGe, 38000 Grenoble, France; Department of pediatrics, Bordeaux university hospital, 38000 Bordeaux, France; Department of neuroradiology and MRI, Grenoble university hospital, 38000 Grenoble, France. Electronic address: akrainik@chu-grenoble.fr.
Abstract
INTRODUCTION: Medulloblastoma is the most common malignant cerebral tumor during childhood, arising in the posterior fossa. Children treated for medulloblastoma often experience working memory (WM) deficits, affecting their quality of life and school performance. The aim of the present study undertaken to describe the cerebellar involvement in WM deficits observed in these children. MATERIAL AND METHODS: 23 healthy children and 11 children treated for medulloblastoma were included into study. All subjects performed a detailed neuropsychological examination, an anatomical and functional MRI. Stimuli were presented to the participants with alternating sensory modality and nature of communication in a block design during functional magnetic resonance imaging acquisitions. Non-parametric tests were used for analyzing neuropsychological and behavioral data. SPM8 and SUIT (Spatially Unbiased Atlas Template) were used for anatomical and functional MRI data analyses. RESULTS: Patients had cerebellar resections mainly located in the left posterior lobe. Patients had significantly reduced intelligence quotient, central executive and visuospatial WM. In healthy children group, fMRI showed activations for non-verbal and visuospatial WM in the left posterior cerebellar lobe. CONCLUSION: This study provides further evidence that left posterior cerebellar lobe plays a critical role in WM. Indeed, lesions of left posterior cerebellar lobe were associated with WM impairment in children treated for cerebellar medulloblastoma. Additionally, fMRI using WM tasks showed activation in the left posterior cerebellar lobe in healthy children. Taken together, these findings may help for improving treatment and rehabilitation of children referred for cerebellar tumor.
INTRODUCTION:Medulloblastoma is the most common malignant cerebral tumor during childhood, arising in the posterior fossa. Children treated for medulloblastoma often experience working memory (WM) deficits, affecting their quality of life and school performance. The aim of the present study undertaken to describe the cerebellar involvement in WM deficits observed in these children. MATERIAL AND METHODS: 23 healthy children and 11 children treated for medulloblastoma were included into study. All subjects performed a detailed neuropsychological examination, an anatomical and functional MRI. Stimuli were presented to the participants with alternating sensory modality and nature of communication in a block design during functional magnetic resonance imaging acquisitions. Non-parametric tests were used for analyzing neuropsychological and behavioral data. SPM8 and SUIT (Spatially Unbiased Atlas Template) were used for anatomical and functional MRI data analyses. RESULTS:Patients had cerebellar resections mainly located in the left posterior lobe. Patients had significantly reduced intelligence quotient, central executive and visuospatial WM. In healthy children group, fMRI showed activations for non-verbal and visuospatial WM in the left posterior cerebellar lobe. CONCLUSION: This study provides further evidence that left posterior cerebellar lobe plays a critical role in WM. Indeed, lesions of left posterior cerebellar lobe were associated with WM impairment in children treated for cerebellar medulloblastoma. Additionally, fMRI using WM tasks showed activation in the left posterior cerebellar lobe in healthy children. Taken together, these findings may help for improving treatment and rehabilitation of children referred for cerebellar tumor.
Authors: Vance T Lehman; David F Black; David R DeLone; Daniel J Blezek; Timothy J Kaufmann; Waleed Brinjikji; Kirk M Welker Journal: Br J Radiol Date: 2020-01-08 Impact factor: 3.039
Authors: Sarah V Clark; Eric S Semmel; Holly A Aleksonis; Stephanie N Steinberg; Tricia Z King Journal: Neuropsychol Rev Date: 2021-01-29 Impact factor: 7.444