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Literature DB >> 3073107

Cloning and nucleotide sequence analysis of the Saccharomyces cerevisiae RAD4 gene required for excision repair of UV-damaged DNA.

Abstract

The RAD4 gene of Saccharomyces cerevisiae is required for the incision step of excision repair. We have cloned the RAD4 gene and determined its nucleotide sequence. RAD4 encodes a somewhat basic protein of 754 amino acids (aa) with an Mr of 87,173. RAD4 contains several groups of 4-7 consecutive basic aa residues that could be involved in DNA binding and it also contains an alpha-helix-turn-alpha-helix motif for DNA binding. Like several other DNA repair proteins of S. cerevisiae, the C terminus of RAD4 protein is highly acidic.

Entities: Gene Species

Mesh：

Substances：
DNA, Fungal

Year: 1988 PMID： 3073107 DOI： 10.1016/0378-1119(88)90186-2

Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688

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Cited

12 in total

1. Rad23 stabilizes Rad4 from degradation by the Ub/proteasome pathway.

Authors: Tatiana G Ortolan; Li Chen; Prasad Tongaonkar; Kiran Madura
Journal: Nucleic Acids Res Date: 2004-12-15 Impact factor: 16.971

2. The Saccharomyces cerevisiae MGT1 DNA repair methyltransferase gene: its promoter and entire coding sequence, regulation and in vivo biological functions.

Authors: W Xiao; L Samson
Journal: Nucleic Acids Res Date: 1992-07-25 Impact factor: 16.971

3. Promoter elements of the PHR1 gene of Saccharomyces cerevisiae and their roles in the response to DNA damage.

Authors: G B Sancar; R Ferris; F W Smith; B Vandeberg
Journal: Nucleic Acids Res Date: 1995-11-11 Impact factor: 16.971

4. Identification of karyopherins involved in the nuclear import of RNA exosome subunit Rrp6 in Saccharomyces cerevisiae.

Authors: Fernando A Gonzales-Zubiate; Ellen K Okuda; Julia P C Da Cunha; Carla Columbano Oliveira
Journal: J Biol Chem Date: 2017-05-24 Impact factor: 5.157

10. A common element involved in transcriptional regulation of two DNA alkylation repair genes (MAG and MGT1) of Saccharomyces cerevisiae.

Authors: W Xiao; K K Singh; B Chen; L Samson
Journal: Mol Cell Biol Date: 1993-12 Impact factor: 4.272

Cloning and nucleotide sequence analysis of the Saccharomyces cerevisiae RAD4 gene required for excision repair of UV-damaged DNA.

1. Rad23 stabilizes Rad4 from degradation by the Ub/proteasome pathway.

2. The Saccharomyces cerevisiae MGT1 DNA repair methyltransferase gene: its promoter and entire coding sequence, regulation and in vivo biological functions.

3. Promoter elements of the PHR1 gene of Saccharomyces cerevisiae and their roles in the response to DNA damage.

4. Identification of karyopherins involved in the nuclear import of RNA exosome subunit Rrp6 in Saccharomyces cerevisiae.

5. Sequence of the mouse XPC cDNA and genomic structure of the human XPC gene.

6. A ubiquitin mutant with specific defects in DNA repair and multiubiquitination.

7. RAD10, an excision repair gene of Saccharomyces cerevisiae, is involved in the RAD1 pathway of mitotic recombination.

8. High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier.

9. Contrasting roles for Myc and Mad proteins in cellular growth and differentiation.

10. A common element involved in transcriptional regulation of two DNA alkylation repair genes (MAG and MGT1) of Saccharomyces cerevisiae.