| Literature DB >> 30731053 |
Bradley Hyman1, Rudolph E Tanzi2.
Abstract
In this issue of Neuron, Neuner et al. (2019) report the generation of Alzheimer's disease (AD) transgenic mouse models on a panel of 28 background strains, showing marked background-dependent phenotypic variability. These findings imply that analogous variation in human AD phenotypes may be due, at least in part, to subtle effects of genetic background.Entities:
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Year: 2019 PMID： 30731053 DOI： 10.1016/j.neuron.2019.01.021
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173