| Literature DB >> 30731002 |
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Abstract
[This corrects the article DOI: 10.1371/journal.pone.0203033.].Entities:
Year: 2019 PMID: 30731002 PMCID: PMC6366699 DOI: 10.1371/journal.pone.0212118
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Respondents’ perceptions towards pharmacogenetics and its implications (n = 617).
| Responses the perception items | Pharmacists | Physicians | Total | P value |
|---|---|---|---|---|
| 1. Pharmacogenetics is relevant to my current clinical practice. | ||||
| Agree | 164 (69.0) | 240 (63.3) | 404 (65.5) | 0.027 |
| Neutral | 55 (23.0) | 121 (32.0) | 176 (28.5) | |
| Disagree | 19 (8.0) | 18 (4.7) | 37 (6.0) | |
| 2. Pharmacists should be required to have some knowledge of pharmacogenetics. | ||||
| Agree | 214 (90.0) | 326 (86.0) | 540 (87.5) | 0.303 |
| Neutral | 19 (8.0) | 45 (12.0) | 64 (10.4) | |
| Disagree | 5 (2.0) | 8 (2.0) | 13 (2.1) | |
| 3. Pharmacogenetic testing should be applied into my clinical practice. | ||||
| Agree | 180 (75.6) | 230 (60.7) | 410 (66.5) | <0.001 |
| Neutral | 50 (21.0) | 137 (36.1) | 187 (30.3) | |
| Disagree | 8 (3.4) | 12 (3.2) | 20 (3.2) | |
| 4. Pharmacists should be asked by healthcare professionals for recommendations on appropriate use of pharmacogenetic testing. | ||||
| Agree | 162 (68.1) | 259 (68.3) | 421 (68.2) | 0.923 |
| Neutral | 63 (26.5) | 102 (27.0) | 165 (26.7) | |
| Disagree | 13 (5.5) | 18 (4.7) | 31 (5.0) | |
| 5. I should be able to provide information on appropriate use of pharmacogenetic testing. | ||||
| Agree | 177 (74.4) | 224 (59.1) | 401 (65.0) | <0.001 |
| Neutral | 43 (18.1) | 137 (36.1) | 180 (29.2) | |
| Disagree | 18 (7.6) | 18 (4.7) | 36 (5.8) | |
| 6. Pharmacogenetics will improve our ability to more effectively control drug therapy expenditures. | ||||
| Agree | 184 (77.3) | 225 (59.4) | 409 (66.3) | <0.001 |
| Neutral | 40 (16.8) | 131 (34.6) | 171 (27.7) | |
| Disagree | 14 (5.9) | 23 (6.1) | 37 (6.0) | |
*Significant difference between physicians and pharmacists using Chi-square test
Respondents’ confidence in applying pharmacogenetics in their practice settings (n = 617).
| Responses to the self-confidence items | Pharmacists | Physicians | Total | P value |
|---|---|---|---|---|
| 1. I can identify drugs that need pharmacogenetic testing. | ||||
| Agree | 59 (24.8) | 86 (22.7) | 145 (23.5) | 0.765 |
| Neutral | 104 (43.7) | 176 (46.4) | 280 (45.4) | |
| Disagree | 75 (31.5) | 117 (30.9) | 192 (31.1) | |
| 2. I can identify reliable sources of information regarding pharmacogenetics for healthcare professionals and patients. | ||||
| Agree | 96 (40.3) | 102 (26.9) | 198 (32.1) | 0.002 |
| Neutral | 85 (35.7) | 166 (43.8) | 251 (40.7) | |
| Disagree | 57 (23.9) | 111 (29.3) | 168 (27.2) | |
| 3. I can readily determine the available pharmacogenetic tests within our healthcare system. | ||||
| Agree | 44 (18.5) | 71 (18.7) | 115 (18.6) | 0.899 |
| Neutral | 96 (40.3) | 146 (38.5) | 242 (39.2) | |
| Disagree | 98 (41.2) | 162 (42.7) | 260 (42.1) | |
| 4. I can accurately apply the results of a pharmacogenetic test to drug therapy selection, dosing, or monitoring. | ||||
| Agree | 64 (26.9) | 101 (26.6) | 165 (26.7) | 0.973 |
| Neutral | 97 (40.8) | 152 (40.1) | 249 (40.4) | |
| Disagree | 77 (32.4) | 126 (33.2) | 203 (32.9) | |
*Significant difference between physicians and pharmacists using Chi-square test
Influence of respondents’ characteristics on their level of knowledge, perceptions, and self-confidence towards pharmacogenetics (n = 617).
| Variable | Overall mean (SD) percentage knowledge score (%) | P value | Overall mean (SD) Perceptions score | P value | Overall mean (SD) | P value |
|---|---|---|---|---|---|---|
| Pharmacist | 48.8 (22.7) | 0.181 | 4.5 (1.7) | <0.001* | 1.1 (1.3) | 0.082 |
| Physician | 43.4 (25.4) | 3.9 (1.9) | 1.0 (1.3) | |||
| ≤35 | 44.4 (23.3) | 0.073 | 4.1 (1.9) | 0.185 | 1.0 (1.3) | 0.094 |
| ≥36 | 47.8 (25.9) | 4.3 (1.7) | 1.1 (1.3) | |||
| Male | 45.7 (25.9) | 0.440 | 4.1 (1.8) | 0.07 | 1.0 (1.2) | 0.061 |
| Female | 45.7 (22.3) | 4.3 (1.8) | 1.1 (1.3) | |||
| <10 | 43.6 (23.3) | 0.002* | 4.0 (1.9) | 0.067 | 0.9 (1.3) | 0.013* |
| ≥10 | 48.0 (25.4) | 4.3 (1.7) | 1.1 (1.3) | |||
| No | 45.7 (25) | 0.970 | 4.1 (1.8) | 0.016* | 0.9 (1.2) | <0.001* |
| Yes | 46.0 (22) | 4.7 (1.8) | 2.0 (1.6) | |||