Luchian Alexandru1,2, Horia Haragus3, Bogdan Deleanu4, Bogdan Timar5, Dan V Poenaru4, Daliborca Cristina Vlad6. 1. Spitalul Clinic de Ortopedie Foișor, Bucharest, Romania. 2. 'Victor Babes' University of Medicine and Pharmacy, Timisoara, Romania. 3. Department of Orthopedics and Trauma, 'Victor Babes' University of Medicine and Pharmacy, Timisoara, Romania. horia.haragus@yahoo.com. 4. Department of Orthopedics and Trauma, 'Victor Babes' University of Medicine and Pharmacy, Timisoara, Romania. 5. Functional Sciences, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania. 6. Department of Pharmacology, 'Victor Babes' University of Medicine and Pharmacy, Timisoara, Romania.
Abstract
PURPOSE: The neutrophil to lymphocyte ratio (NLR) is a simple predictor used in oncology and cardiology. We aimed to analyze the NLR profile of patients with diaphyseal fractures of the humerus, femur, and tibia. METHODS: We performed a cross-sectional, consecutive-case population-based study including 148 patients (41.9% men respectively 58.1% women) with humeral (23.0%), femoral (30.4%), and tibial (46.6%) diaphyseal fractures, admitted for surgical treatment in our level 1 trauma centre over two years. RESULTS: The differences in NLR between the studied subgroups were not significant (p = 0.067), the highest value being observed in patients with femoral fracture (5.6) in contrast to patients with humeral fracture (4). In the global cohort, there was a significantly positive correlation between NLR and PLR (platelet to lymphocyte ratio; Spearman's r = 0.595; p < 0.001). The stratified subgroup analysis found significant association between NLR and duration of admission only for patients with femoral fracture (Spearman's r = - 0.308; p < 0.001). When compared with controls, all three fracture types had significantly higher neutrophil numbers and NLR and lower thrombocyte numbers. CONCLUSIONS: NLR are elevated in femur diaphyseal fractures compared with tibia and humerus, up to cut-off values with negative prediction of outcome in malignancy and cardiovascular patients. Increased NLR are predictive of longer hospital admissions for femur fractures.
PURPOSE: The neutrophil to lymphocyte ratio (NLR) is a simple predictor used in oncology and cardiology. We aimed to analyze the NLR profile of patients with diaphyseal fractures of the humerus, femur, and tibia. METHODS: We performed a cross-sectional, consecutive-case population-based study including 148 patients (41.9% men respectively 58.1% women) with humeral (23.0%), femoral (30.4%), and tibial (46.6%) diaphyseal fractures, admitted for surgical treatment in our level 1 trauma centre over two years. RESULTS: The differences in NLR between the studied subgroups were not significant (p = 0.067), the highest value being observed in patients with femoral fracture (5.6) in contrast to patients with humeral fracture (4). In the global cohort, there was a significantly positive correlation between NLR and PLR (platelet to lymphocyte ratio; Spearman's r = 0.595; p < 0.001). The stratified subgroup analysis found significant association between NLR and duration of admission only for patients with femoral fracture (Spearman's r = - 0.308; p < 0.001). When compared with controls, all three fracture types had significantly higher neutrophil numbers and NLR and lower thrombocyte numbers. CONCLUSIONS: NLR are elevated in femur diaphyseal fractures compared with tibia and humerus, up to cut-off values with negative prediction of outcome in malignancy and cardiovascularpatients. Increased NLR are predictive of longer hospital admissions for femur fractures.
Entities:
Keywords:
Femur; Fracture; Humerus; Inflammation; Neutrophil to lymphocyte ratio; Tibia
Authors: Arnoud J Templeton; Mairéad G McNamara; Boštjan Šeruga; Francisco E Vera-Badillo; Priya Aneja; Alberto Ocaña; Raya Leibowitz-Amit; Guru Sonpavde; Jennifer J Knox; Ben Tran; Ian F Tannock; Eitan Amir Journal: J Natl Cancer Inst Date: 2014-05-29 Impact factor: 13.506
Authors: Cosmin Ioan Faur; Daniel Laurenţiu Pop; Andrei Gheorghe Marius Motoc; Roxana Folescu; Mirela Loredana Grigoraş; Daniela Gurguş; Carmen Lăcrămioara Zamfir; Mihaela Iacob; Dinu Vermeşan; Bogdan Nicolae Deleanu; Horia George Hărăguş; Daniel Claudiu Maliţa; Ahmed Abu-Awwad; Ion Lucian Ghiga; Mariana Tudoran Journal: Rom J Morphol Embryol Date: 2020 Impact factor: 1.033