Andrea L C Schneider1, Matthew L Senjem2, Aozhou Wu2, Alden Gross2, David S Knopman2, Jeffrey L Gunter2, Christopher G Schwarz2, Thomas H Mosley2, Rebecca F Gottesman2, A Richey Sharrett2, Clifford R Jack2. 1. From the Department of Neurology (A.L.C.S., R.F.G.), Johns Hopkins University School of Medicine, Baltimore, MD; Departments of Radiology (M.L.S., J.L.G., C.G.S. C.R.J.), Information Technology (M.L.S., J.L.G.), and Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Department of Epidemiology (A.W., A.G., R.F.G., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Johns Hopkins University Center on Aging and Health (A.G.), Baltimore, MD; and Department of Geriatrics (T.H.M.), University of Mississippi Medical Center, Jackson. achris13@jhmi.edu. 2. From the Department of Neurology (A.L.C.S., R.F.G.), Johns Hopkins University School of Medicine, Baltimore, MD; Departments of Radiology (M.L.S., J.L.G., C.G.S. C.R.J.), Information Technology (M.L.S., J.L.G.), and Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Department of Epidemiology (A.W., A.G., R.F.G., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Johns Hopkins University Center on Aging and Health (A.G.), Baltimore, MD; and Department of Geriatrics (T.H.M.), University of Mississippi Medical Center, Jackson.
Abstract
OBJECTIVE: To evaluate the association of cognitive declines in the domains of memory, language, and executive function with brain gray matter (GM) volume in old age. METHODS: This was a prospective study of 1,846 participants in the Atherosclerosis Risk in Communities (ARIC) Study who underwent 3T brain MRI scans in 2011 to 2013. Participants were categorized by cognitive domain performance trajectory over the prior 20 years (cut point to define decline: 20th percentile). Associations between GM volume and cognitive declines were assessed at the voxel level with voxel-based morphometry and at the regional level with atlas-defined GM volumes of specific regions of interest. RESULTS: Participants were an average age of 76 years; 60% were female; and 28% were black. Participants in the top 20th percentile for decline in the memory domain had smaller GM volumes in the medial temporal lobe (-3.3%, 95% confidence interval [CI] -4.6% to -2.1%), amygdala (-2.7%, 95% CI -4.1% to -1.3%), entorhinal cortex (-4.1%, 95% CI -6.0% to -2.2%), and hippocampus (-3.8%, 95% CI -5.2% to -2.4%) compared to participants who were in the lowest 80th percentile for decline in all domains. In contrast, among participants who were in the top 20th percentile for decline in the language or executive function domains, GM volumes were smaller in more brain regions. CONCLUSIONS: Declines in memory function were associated with brain volume loss in the medial temporal and hippocampal formations. Declines in language and executive function were associated with decreases in brain volumes across more noncontiguous brain regions.
OBJECTIVE: To evaluate the association of cognitive declines in the domains of memory, language, and executive function with brain gray matter (GM) volume in old age. METHODS: This was a prospective study of 1,846 participants in the Atherosclerosis Risk in Communities (ARIC) Study who underwent 3T brain MRI scans in 2011 to 2013. Participants were categorized by cognitive domain performance trajectory over the prior 20 years (cut point to define decline: 20th percentile). Associations between GM volume and cognitive declines were assessed at the voxel level with voxel-based morphometry and at the regional level with atlas-defined GM volumes of specific regions of interest. RESULTS: Participants were an average age of 76 years; 60% were female; and 28% were black. Participants in the top 20th percentile for decline in the memory domain had smaller GM volumes in the medial temporal lobe (-3.3%, 95% confidence interval [CI] -4.6% to -2.1%), amygdala (-2.7%, 95% CI -4.1% to -1.3%), entorhinal cortex (-4.1%, 95% CI -6.0% to -2.2%), and hippocampus (-3.8%, 95% CI -5.2% to -2.4%) compared to participants who were in the lowest 80th percentile for decline in all domains. In contrast, among participants who were in the top 20th percentile for decline in the language or executive function domains, GM volumes were smaller in more brain regions. CONCLUSIONS: Declines in memory function were associated with brain volume loss in the medial temporal and hippocampal formations. Declines in language and executive function were associated with decreases in brain volumes across more noncontiguous brain regions.
Authors: N Tzourio-Mazoyer; B Landeau; D Papathanassiou; F Crivello; O Etard; N Delcroix; B Mazoyer; M Joliot Journal: Neuroimage Date: 2002-01 Impact factor: 6.556
Authors: Susan M Resnick; Dzung L Pham; Michael A Kraut; Alan B Zonderman; Christos Davatzikos Journal: J Neurosci Date: 2003-04-15 Impact factor: 6.167
Authors: Ruth Ruscheweyh; Michael Deppe; Hubertus Lohmann; Heike Wersching; Catharina Korsukewitz; Thomas Duning; Saskia Bluhm; Christoph Stehling; Simon S Keller; Stefan Knecht Journal: Hum Brain Mapp Date: 2012-07-19 Impact factor: 5.038
Authors: Paul K Crane; Emily Trittschuh; Shubhabrata Mukherjee; Andrew J Saykin; R Elizabeth Sanders; Eric B Larson; Susan M McCurry; Wayne McCormick; James D Bowen; Thomas Grabowski; Mackenzie Moore; Julianna Bauman; Alden L Gross; C Dirk Keene; Thomas D Bird; Laura E Gibbons; Jesse Mez Journal: Alzheimers Dement Date: 2017-06-15 Impact factor: 21.566
Authors: D S Knopman; A D Penman; D J Catellier; L H Coker; D K Shibata; A R Sharrett; T H Mosley Journal: Neurology Date: 2011-05-04 Impact factor: 9.910
Authors: Alessandro Orlando; A Richey Sharrett; Andrea L C Schneider; Rebecca F Gottesman; David S Knopman; Andreea Rawlings; Thomas H Mosley; Clifford R Jack; Dean Wong; James R Pike; Josef Coresh Journal: Neuroepidemiology Date: 2022-05-02 Impact factor: 5.393
Authors: Caitlin W Hicks; Dan Wang; Andrea L C Schneider; Michelle C Johansen; Rebecca F Gottesman; Kunihiro Matsushita; Josef Coresh; B Gwen Windham; Elizabeth Selvin Journal: Dement Geriatr Cogn Disord Date: 2022-03-28 Impact factor: 3.346
Authors: Raihaan Patel; Clare E Mackay; Michelle G Jansen; Gabriel A Devenyi; M Clare O'Donoghue; Mika Kivimäki; Archana Singh-Manoux; Enikő Zsoldos; Klaus P Ebmeier; M Mallar Chakravarty; Sana Suri Journal: Neuroimage Date: 2022-04-28 Impact factor: 7.400