Literature DB >> 30726758

A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21.

Steven A Kliewer1, David J Mangelsdorf2.   

Abstract

It has been more than a dozen years since FGF21 burst on the metabolism field in a paper showing that its pharmacologic administration caused weight loss and improved insulin sensitivity and lipoprotein profiles in obese rodents. Since then, FGF21 analogs have advanced all the way to clinical trials, and much progress has been made in understanding FGF21's pharmacology and physiology. In this Perspective, we highlight some of the interesting themes that have emerged from this first dozen years of FGF21 research, including its roles in autocrine/paracrine and endocrine responses to metabolic stress.
Copyright © 2019 Elsevier Inc. All rights reserved.

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Year:  2019        PMID： 30726758      PMCID： PMC6368396          DOI： 10.1016/j.cmet.2019.01.004

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  81 in total

1.  The fasting polypeptide FGF21 can enter brain from blood.

Authors:  Hung Hsuchou; Weihong Pan; Abba J Kastin
Journal:  Peptides       Date:  2007-10-18       Impact factor: 3.750

2.  Thermogenic activation induces FGF21 expression and release in brown adipose tissue.

Authors:  Elayne Hondares; Roser Iglesias; Albert Giralt; Frank J Gonzalez; Marta Giralt; Teresa Mampel; Francesc Villarroya
Journal:  J Biol Chem       Date:  2011-02-13       Impact factor: 5.157

3.  Novel locus including FGF21 is associated with dietary macronutrient intake.

Authors:  Audrey Y Chu; Tsegaselassie Workalemahu; Nina P Paynter; Lynda M Rose; Franco Giulianini; Toshiko Tanaka; Julius S Ngwa; Qibin Qi; Gary C Curhan; Eric B Rimm; David J Hunter; Louis R Pasquale; Paul M Ridker; Frank B Hu; Daniel I Chasman; Lu Qi
Journal:  Hum Mol Genet       Date:  2013-01-30       Impact factor: 6.150

4.  The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity.

Authors:  Zhe Huang; Ling Zhong; Jimmy Tsz Hang Lee; Jialiang Zhang; Donghai Wu; Leiluo Geng; Yu Wang; Chi-Ming Wong; Aimin Xu
Journal:  Cell Metab       Date:  2017-08-24       Impact factor: 27.287

5.  Identification of a novel FGF, FGF-21, preferentially expressed in the liver.

Authors:  T Nishimura; Y Nakatake; M Konishi; N Itoh
Journal:  Biochim Biophys Acta       Date:  2000-06-21

6.  KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.

Authors:  Gunter Schumann; Chunyu Liu; Paul O'Reilly; He Gao; Parkyong Song; Bing Xu; Barbara Ruggeri; Najaf Amin; Tianye Jia; Sarah Preis; Marcelo Segura Lepe; Shizuo Akira; Caterina Barbieri; Sebastian Baumeister; Stephane Cauchi; Toni-Kim Clarke; Stefan Enroth; Krista Fischer; Jenni Hällfors; Sarah E Harris; Saskia Hieber; Edith Hofer; Jouke-Jan Hottenga; Åsa Johansson; Peter K Joshi; Niina Kaartinen; Jaana Laitinen; Rozenn Lemaitre; Anu Loukola; Jian'an Luan; Leo-Pekka Lyytikäinen; Massimo Mangino; Ani Manichaikul; Hamdi Mbarek; Yuri Milaneschi; Alireza Moayyeri; Kenneth Mukamal; Christopher Nelson; Jennifer Nettleton; Eemil Partinen; Rajesh Rawal; Antonietta Robino; Lynda Rose; Cinzia Sala; Takashi Satoh; Reinhold Schmidt; Katharina Schraut; Robert Scott; Albert Vernon Smith; John M Starr; Alexander Teumer; Stella Trompet; André G Uitterlinden; Cristina Venturini; Anne-Claire Vergnaud; Niek Verweij; Veronique Vitart; Dragana Vuckovic; Juho Wedenoja; Loic Yengo; Bing Yu; Weihua Zhang; Jing Hua Zhao; Dorret I Boomsma; John Chambers; Daniel I Chasman; Toniolo Daniela; Eco de Geus; Ian Deary; Johan G Eriksson; Tõnu Esko; Volker Eulenburg; Oscar H Franco; Philippe Froguel; Christian Gieger; Hans J Grabe; Vilmundur Gudnason; Ulf Gyllensten; Tamara B Harris; Anna-Liisa Hartikainen; Andrew C Heath; Lynne Hocking; Albert Hofman; Cornelia Huth; Marjo-Riitta Jarvelin; J Wouter Jukema; Jaakko Kaprio; Jaspal S Kooner; Zoltan Kutalik; Jari Lahti; Claudia Langenberg; Terho Lehtimäki; Yongmei Liu; Pamela A F Madden; Nicholas Martin; Alanna Morrison; Brenda Penninx; Nicola Pirastu; Bruce Psaty; Olli Raitakari; Paul Ridker; Richard Rose; Jerome I Rotter; Nilesh J Samani; Helena Schmidt; Tim D Spector; David Stott; David Strachan; Ioanna Tzoulaki; Pim van der Harst; Cornelia M van Duijn; Pedro Marques-Vidal; Peter Vollenweider; Nicholas J Wareham; John B Whitfield; James Wilson; Bruce Wolffenbuttel; Georgy Bakalkin; Evangelos Evangelou; Yun Liu; Kenneth M Rice; Sylvane Desrivières; Steven A Kliewer; David J Mangelsdorf; Christian P Müller; Daniel Levy; Paul Elliott
Journal:  Proc Natl Acad Sci U S A       Date:  2016-11-28       Impact factor: 11.205

7.  Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets.

Authors:  Ffolliott M Fisher; Patricia C Chui; Imad A Nasser; Yury Popov; Jeremy C Cunniff; Thomas Lundasen; Alexei Kharitonenkov; Detlef Schuppan; Jeffrey S Flier; Eleftheria Maratos-Flier
Journal:  Gastroenterology       Date:  2014-07-30       Impact factor: 22.682

8.  Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice.

Authors:  Zhuofeng Lin; Haishan Tian; Karen S L Lam; Shaoqiang Lin; Ruby C L Hoo; Morichika Konishi; Nobuyuki Itoh; Yu Wang; Stefan R Bornstein; Aimin Xu; Xiaokun Li
Journal:  Cell Metab       Date:  2013-05-07       Impact factor: 27.287

9.  FGF21 promotes metabolic homeostasis via white adipose and leptin in mice.

Authors:  Murielle M Véniant; Clarence Hale; Joan Helmering; Michelle M Chen; Shanaka Stanislaus; Jim Busby; Steven Vonderfecht; Jing Xu; David J Lloyd
Journal:  PLoS One       Date:  2012-07-06       Impact factor: 3.240

10.  Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury.

Authors:  Yanlong Liu; Cuiqing Zhao; Jian Xiao; Liming Liu; Min Zhang; Cuiling Wang; Guicheng Wu; Ming-Hua Zheng; Lan-Man Xu; Yong-Ping Chen; Moosa Mohammadi; Shao-Yu Chen; Matthew Cave; Craig McClain; Xiaokun Li; Wenke Feng
Journal:  Sci Rep       Date:  2016-08-08       Impact factor: 4.379
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  56 in total

1.  Probiotic culture supernatant improves metabolic function through FGF21-adiponectin pathway in mice.

Authors:  Qi Liu; Yunhuan Liu; Fengyuan Li; Zelin Gu; Min Liu; Tuo Shao; Lihua Zhang; Guangyao Zhou; Chengwei Pan; Liqing He; Jun Cai; Xiang Zhang; Shirish Barve; Craig J McClain; Yiping Chen; Wenke Feng
Journal:  J Nutr Biochem       Date:  2019-10-24       Impact factor: 6.048

Review 2.  Obesity medications in development.

Authors:  Candida J Rebello; Frank L Greenway
Journal:  Expert Opin Investig Drugs       Date:  2019-12-19       Impact factor: 6.206

3.  Dietary Methionine Restriction Reduces Inflammation Independent of FGF21 Action.

Authors:  Shaligram Sharma; Taylor Dixon; Sean Jung; Emily C Graff; Laura A Forney; Thomas W Gettys; Desiree Wanders
Journal:  Obesity (Silver Spring)       Date:  2019-06-17       Impact factor: 5.002

4.  Weight Loss and Concomitant Adipose Autophagy in Methionine-Restricted Obese Mice is Not Dependent on Adiponectin or FGF21.

Authors:  Diana Cooke; Dwight Mattocks; Sailendra N Nichenametla; Rea P Anunciado-Koza; Robert A Koza; Gene P Ables
Journal:  Obesity (Silver Spring)       Date:  2020-04-29       Impact factor: 5.002

Review 5.  Growth Factors as Immunotherapeutic Targets in Cardiovascular Disease.

Authors:  John E Mindur; Filip K Swirski
Journal:  Arterioscler Thromb Vasc Biol       Date:  2019-05-16       Impact factor: 8.311

Review 6.  Leveraging the Gut to Treat Metabolic Disease.

Authors:  Ruth E Gimeno; Daniel A Briere; Randy J Seeley
Journal:  Cell Metab       Date:  2020-03-17       Impact factor: 27.287

7.  Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy.

Authors:  Genaro Hernandez; Ting Luo; Tanveer A Javed; Li Wen; Michael A Kalwat; Kevin Vale; Farah Ammouri; Sohail Z Husain; Steven A Kliewer; David J Mangelsdorf
Journal:  Sci Transl Med       Date:  2020-01-08       Impact factor: 17.956

Review 8.  Inter-organ cross-talk in metabolic syndrome.

Authors:  Christina Priest; Peter Tontonoz
Journal:  Nat Metab       Date:  2019-12-09

9.  FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition.

Authors:  Shannon M Reilly; Mohammad Abu-Odeh; Magdalene Ameka; Julia H DeLuca; Meghan C Naber; Benyamin Dadpey; Nima Ebadat; Andrew V Gomez; Xiaoling Peng; BreAnne Poirier; Elyse Walk; Matthew J Potthoff; Alan R Saltiel
Journal:  J Clin Invest       Date:  2021-05-17       Impact factor: 14.808

Review 10.  The endocrine role of brown adipose tissue: An update on actors and actions.

Authors:  Aleix Gavaldà-Navarro; Joan Villarroya; Rubén Cereijo; Marta Giralt; Francesc Villarroya
Journal:  Rev Endocr Metab Disord       Date:  2021-03-12       Impact factor: 6.514
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