Literature DB >> 30726756

mTOR Is Key to T Cell Transdifferentiation.

Jiawei Yan1, Ruoning Wang2, Tiffany Horng3.   

Abstract

T cell transdifferentiation to functionally distinct subsets can play a key role in balancing the protective and pathogenic features of the T cell response. In a new study, Karmaus et al. (2019) showed that mTORC1 activity influences metabolic heterogeneity within a T cell population to modulate transdifferentiation and disease pathogenesis in a setting of chronic inflammation-driven autoimmunity.
Copyright © 2019 Elsevier Inc. All rights reserved.

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Year:  2019        PMID： 30726756      PMCID： PMC6556472          DOI： 10.1016/j.cmet.2019.01.008

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  10 in total

Review 1.  An overview of the immune system.

Authors:  J Parkin; B Cohen
Journal:  Lancet       Date:  2001-06-02       Impact factor: 79.321

Review 2.  Plasticity of CD4+ T cell lineage differentiation.

Authors:  Liang Zhou; Mark M W Chong; Dan R Littman
Journal:  Immunity       Date:  2009-05       Impact factor: 31.745

Review 3.  The dichotomous nature of T helper 17 cells.

Authors:  Brigitta Stockinger; Sara Omenetti
Journal:  Nat Rev Immunol       Date:  2017-05-30       Impact factor: 53.106

4.  Genetic proof for the transient nature of the Th17 phenotype.

Authors:  Florian C Kurschus; Andrew L Croxford; André P Heinen; Simone Wörtge; Daniele Ielo; Ari Waisman
Journal:  Eur J Immunol       Date:  2010-12       Impact factor: 5.532

5.  Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation.

Authors:  Nicola Gagliani; Maria Carolina Amezcua Vesely; Andrea Iseppon; Leonie Brockmann; Hao Xu; Noah W Palm; Marcel R de Zoete; Paula Licona-Limón; Ricardo S Paiva; Travers Ching; Casey Weaver; Xiaoyuan Zi; Xinghua Pan; Rong Fan; Lana X Garmire; Matthew J Cotton; Yotam Drier; Bradley Bernstein; Jens Geginat; Brigitta Stockinger; Enric Esplugues; Samuel Huber; Richard A Flavell
Journal:  Nature       Date:  2015-04-29       Impact factor: 49.962

6.  Fate mapping of IL-17-producing T cells in inflammatory responses.

Authors:  Keiji Hirota; João H Duarte; Marc Veldhoen; Eve Hornsby; Ying Li; Daniel J Cua; Helena Ahlfors; Christoph Wilhelm; Mauro Tolaini; Ursula Menzel; Anna Garefalaki; Alexandre J Potocnik; Brigitta Stockinger
Journal:  Nat Immunol       Date:  2011-01-30       Impact factor: 25.606

Review 7.  mTOR Links Environmental Signals to T Cell Fate Decisions.

Authors:  Nicole M Chapman; Hongbo Chi
Journal:  Front Immunol       Date:  2015-01-20       Impact factor: 7.561

8.  Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity.

Authors:  Peer W F Karmaus; Xiang Chen; Seon Ah Lim; Andrés A Herrada; Thanh-Long M Nguyen; Beisi Xu; Yogesh Dhungana; Sherri Rankin; Wenan Chen; Celeste Rosencrance; Kai Yang; Yiping Fan; Yong Cheng; John Easton; Geoffrey Neale; Peter Vogel; Hongbo Chi
Journal:  Nature       Date:  2018-12-19       Impact factor: 49.962

9.  Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8(+) T cell differentiation.

Authors:  Kristen N Pollizzi; Im-Hong Sun; Chirag H Patel; Ying-Chun Lo; Min-Hee Oh; Adam T Waickman; Ada J Tam; Richard L Blosser; Jiayu Wen; Greg M Delgoffe; Jonathan D Powell
Journal:  Nat Immunol       Date:  2016-04-11       Impact factor: 25.606

10.  Metabolic maintenance of cell asymmetry following division in activated T lymphocytes.

Authors:  Katherine C Verbist; Cliff S Guy; Sandra Milasta; Swantje Liedmann; Marcin M Kamiński; Ruoning Wang; Douglas R Green
Journal:  Nature       Date:  2016-04-11       Impact factor: 49.962
  10 in total
  4 in total

1.  Cardamonin suppresses pro-tumor function of macrophages by decreasing M2 polarization on ovarian cancer cells via mTOR inhibition.

Authors:  Huajiao Chen; Sheng Huang; Peiguang Niu; Yanting Zhu; Jintuo Zhou; Li Jiang; Danyun Li; Daohua Shi
Journal:  Mol Ther Oncolytics       Date:  2022-06-25       Impact factor: 6.311

Review 2.  Deficiency in the Treatment Description of mTOR Inhibitor Resistance in Medulloblastoma, a Systematic Review.

Authors:  Hajar Alammar; Rayan Nassani; Mana M Alshehri; Alaa A Aljohani; Bahauddeen M Alrfaei
Journal:  Int J Mol Sci       Date:  2021-12-31       Impact factor: 5.923

3.  Overexpressing Kallistatin Aggravates Experimental Autoimmune Uveitis Through Promoting Th17 Differentiation.

Authors:  Nu Chen; Shuang Chen; Zhihui Zhang; Xuexue Cui; Lingzi Wu; Kailei Guo; Hui Shao; Jian-Xing Ma; Xiaomin Zhang
Journal:  Front Immunol       Date:  2021-10-18       Impact factor: 7.561

Review 4.  Causal Links between Hypovitaminosis D and Dysregulation of the T Cell Connection of Immunity Associated with Obesity and Concomitant Pathologies.

Authors:  Natalia Todosenko; Maria Vulf; Kristina Yurova; Olga Khaziakhmatova; Larisa Mikhailova; Larisa Litvinova
Journal:  Biomedicines       Date:  2021-11-23
  4 in total

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