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Literature DB >> 30724134

Development of Modular, Dual-Perfused Osteochondral Constructs for Cartilage Repair.

Ethan L H Daley¹, Jochen Kuttig², Jan P Stegemann¹.

Abstract

IMPACT STATEMENT: This study describes methods for fabricating, culturing, and characterizing modular microbeads containing progenitor cells that can be used to create osteochondral tissue constructs. Such biphasic engineered tissues were cultured in a low flow rate perfusion bioreactor chamber to maintain tissue-specific differentiation while allowing development of the osteochondral interface.

Keywords: 3D cell culture; bioreactor; cartilage; hydrogels; mesenchymal stem cell; modular tissue engineering; osteochondral

Mesh：

Year: 2019 PMID： 30724134 PMCID： PMC6457327 DOI： 10.1089/ten.TEC.2018.0356

Source DB: PubMed Journal: Tissue Eng Part C Methods ISSN： 1937-3384 Impact factor: 3.056

28 in total

1. Type I collagen-induced osteoblastic differentiation of bone-marrow cells mediated by collagen-alpha2beta1 integrin interaction.

Authors: M Mizuno; R Fujisawa; Y Kuboki
Journal: J Cell Physiol Date: 2000-08 Impact factor: 6.384

2. Spatial regulation of human mesenchymal stem cell differentiation in engineered osteochondral constructs: effects of pre-differentiation, soluble factors and medium perfusion.

Authors: W L Grayson; S Bhumiratana; P H Grace Chao; C T Hung; G Vunjak-Novakovic
Journal: Osteoarthritis Cartilage Date: 2010-02-06 Impact factor: 6.576

3. In vitro generation of an osteochondral interface from mesenchymal stem cell-collagen microspheres.

Authors: Hiu-Wa Cheng; Keith D K Luk; Kenneth M C Cheung; Barbara P Chan
Journal: Biomaterials Date: 2010-11-18 Impact factor: 12.479

4. Collagen modules for in situ delivery of mesenchymal stromal cell-derived endothelial cells for improved angiogenesis.

Authors: Karolina Janeczek Portalska; M Dean Chamberlain; Chuen Lo; Clemens van Blitterswijk; Michael V Sefton; Jan de Boer
Journal: J Tissue Eng Regen Med Date: 2013-04-17 Impact factor: 3.963

Review 5. Nanoscale hydroxyapatite particles for bone tissue engineering.

Authors: Hongjian Zhou; Jaebeom Lee
Journal: Acta Biomater Date: 2011-04-01 Impact factor: 8.947

6. The biocompatibility and osteoconductive activity of a novel hydroxyapatite/collagen composite biomaterial, and its function as a carrier of rhBMP-2.

Authors: S Itoh; M Kikuchi; K Takakuda; Y Koyama; H N Matsumoto; S Ichinose; J Tanaka; T Kawauchi; K Shinomiya
Journal: J Biomed Mater Res Date: 2001-03-05

Development of Modular, Dual-Perfused Osteochondral Constructs for Cartilage Repair.

1. Type I collagen-induced osteoblastic differentiation of bone-marrow cells mediated by collagen-alpha2beta1 integrin interaction.

2. Spatial regulation of human mesenchymal stem cell differentiation in engineered osteochondral constructs: effects of pre-differentiation, soluble factors and medium perfusion.

3. In vitro generation of an osteochondral interface from mesenchymal stem cell-collagen microspheres.

4. Collagen modules for in situ delivery of mesenchymal stromal cell-derived endothelial cells for improved angiogenesis.

Review 5. Nanoscale hydroxyapatite particles for bone tissue engineering.

6. The biocompatibility and osteoconductive activity of a novel hydroxyapatite/collagen composite biomaterial, and its function as a carrier of rhBMP-2.

Review 7. Osteocalcin-hydroxyapatite interaction in the extracellular organic matrix of bone.

8. Autologous engineering of cartilage.

Review 9. Agarose-based biomaterials for tissue engineering.

10. Multi-layered collagen-based scaffolds for osteochondral defect repair in rabbits.

Review 1. Current Advances in 3D Bioprinting Technology and Its Applications for Tissue Engineering.

Review 2. Macro, Micro, and Molecular. Changes of the Osteochondral Interface in Osteoarthritis Development.