Literature DB >> 30724130

Engineering Human Stasis for Long-Duration Spaceflight.

Claire A Nordeen1, Sandra L Martin2.   

Abstract

Suspended animation for deep-space travelers is moving out of the realm of science fiction. Two approaches are considered: the first elaborates the current medical practice of therapeutic hypothermia; the second invokes the cascade of metabolic processes naturally employed by hibernators. We explore the basis and evidence behind each approach and argue that mimicry of natural hibernation will be critical to overcome the innate limitations of human physiology for long-duration space travel.

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Year:  2019        PMID: 30724130     DOI: 10.1152/physiol.00046.2018

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN: 1548-9221


  9 in total

1.  A robust diving response in the laboratory mouse.

Authors:  Elissa M Hult; Mark J Bingaman; Steven J Swoap
Journal:  J Comp Physiol B       Date:  2019-09-24       Impact factor: 2.200

2.  Shallow metabolic depression and human spaceflight: a feasible first step.

Authors:  Matthew D Regan; Erin E Flynn-Evans; Yuri V Griko; Thomas S Kilduff; Jon C Rittenberger; Keith J Ruskin; C Loren Buck
Journal:  J Appl Physiol (1985)       Date:  2020-01-30

3.  Future trends in measuring physiology in free-living animals.

Authors:  H J Williams; J Ryan Shipley; C Rutz; M Wikelski; M Wilkes; L A Hawkes
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2021-06-28       Impact factor: 6.671

Review 4.  Winter is coming: the future of cryopreservation.

Authors:  Sanja Bojic; Alex Murray; Roman Bauer; João Pedro de Magalhães; Barry L Bentley; Ralf Spindler; Piotr Pawlik; José L Cordeiro
Journal:  BMC Biol       Date:  2021-03-24       Impact factor: 7.431

Review 5.  The Frailty Puzzle: Searching for Immortality or for Knowledge Survival?

Authors:  Stefano Govoni; Francesca Fagiani; Cristina Lanni; Nicola Allegri
Journal:  Front Cell Neurosci       Date:  2022-02-17       Impact factor: 5.505

6.  Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons.

Authors:  Tina Pekec; Jarosław Lewandowski; Alicja A Komur; Daria Sobańska; Yanwu Guo; Karolina Świtońska-Kurkowska; Jędrzej M Małecki; Abhishek Anil Dubey; Wojciech Pokrzywa; Marcin Frankowski; Maciej Figiel; Rafal Ciosk
Journal:  Nat Commun       Date:  2022-08-19       Impact factor: 17.694

7.  The 2019 WACEM and Academic College of Emergency Experts India Position Paper on Developing the Academic Department of Space Medicine in India - The Time Has Come!

Authors:  Vivek Chauhan; Sagar Galwankar; Kishore K Deepak; Anant Mohan; Randeep Guleria; Sanjeev Bhoi; Praveen Aggarwal
Journal:  J Emerg Trauma Shock       Date:  2019-11-18

8.  Cold-induced chromatin compaction and nuclear retention of clock mRNAs resets the circadian rhythm.

Authors:  Harry Fischl; David McManus; Roel Oldenkamp; Lothar Schermelleh; Jane Mellor; Aarti Jagannath; André Furger
Journal:  EMBO J       Date:  2020-10-09       Impact factor: 14.012

9.  A Temporal Examination of Cytoplasmic Ca2 + Levels, Sarcoplasmic Reticulum Ca2 + Levels, and Ca2 + -Handling-Related Proteins in Different Skeletal Muscles of Hibernating Daurian Ground Squirrels.

Authors:  Zhe Wang; Jie Zhang; Xiu-Feng Ma; Hui Chang; Xin Peng; Shen-Hui Xu; Hui-Ping Wang; Yun-Fang Gao
Journal:  Front Physiol       Date:  2020-10-21       Impact factor: 4.566

  9 in total

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