Sati Akbaba1,2,3, Kristin Lang1,2,3, Olcay Cem Bulut4, Thomas Held1,2,3, Stefan Rieken1,2,3, Peter Plinkert4, Alexandra Jensen5, Klaus Herfarth1,2,3, Juergen Debus1,2,3, Sebastian Adeberg1,2,3. 1. Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany. 2. Department of Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany. 3. Department of Radiation Oncology, Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany. 4. Department of Otolaryngology, Head and Neck Surgery, University Hospital Heidelberg, Heidelberg, Germany. 5. Department of Radiation Oncology, University Hospital Giessen, Gießen, Germany.
Abstract
BACKGROUND: To evaluate clinical outcome and functional larynx preservation after radiotherapy (RT) for adenoid cystic carcinoma (ACC) of the larynx. METHODS: Eleven patients with primary ACC of the larynx, who received RT definitely (n = 5/11) or postoperatively (n = 6/11), were analyzed regarding survival and treatment-related toxicity with the focus on functional larynx preservation. RESULTS: Median follow-up was 45 months. RT offered an excellent 5-year local control (LC) rate of 100%. Eight of 11 patients were treated with a laryngeal preservation approach (LPA). At last follow-up, only one of these eight patients developed a local recurrence requiring a total laryngectomy 11 years after treatment. Severe toxicity was uncommon, with only one patient with LPA, requiring a temporary tracheostomy during therapy. CONCLUSIONS: RT is an effective treatment method for laryngeal ACC with excellent LC rates, preservation of the laryngeal function and voice formation, representing a valuable therapy alternative to total laryngectomy.
BACKGROUND: To evaluate clinical outcome and functional larynx preservation after radiotherapy (RT) for adenoid cystic carcinoma (ACC) of the larynx. METHODS: Eleven patients with primary ACC of the larynx, who received RT definitely (n = 5/11) or postoperatively (n = 6/11), were analyzed regarding survival and treatment-related toxicity with the focus on functional larynx preservation. RESULTS: Median follow-up was 45 months. RT offered an excellent 5-year local control (LC) rate of 100%. Eight of 11 patients were treated with a laryngeal preservation approach (LPA). At last follow-up, only one of these eight patients developed a local recurrence requiring a total laryngectomy 11 years after treatment. Severe toxicity was uncommon, with only one patient with LPA, requiring a temporary tracheostomy during therapy. CONCLUSIONS: RT is an effective treatment method for laryngeal ACC with excellent LC rates, preservation of the laryngeal function and voice formation, representing a valuable therapy alternative to total laryngectomy.
Authors: Sebastian Adeberg; Paul Windisch; Felix Ehret; Melissa Baur; Sati Akbaba; Thomas Held; Denise Bernhardt; Matthias F Haefner; Juergen Krauss; Steffen Kargus; Christian Freudlsperger; Peter Plinkert; Christa Flechtenmacher; Klaus Herfarth; Juergen Debus; Stefan Rieken Journal: Front Oncol Date: 2019-12-20 Impact factor: 6.244