| Literature DB >> 30722784 |
Yusef Moulla1, Tanja Gradistanac2, Christian Wittekind2, Uwe Eichfeld3, Ines Gockel3, Arne Dietrich3.
Abstract
The original article [1] contains slight errors whereby several terms in the first column of Tables 1, 2, and 3 have an erroneous 'p' preceding them.Entities:
Year: 2019 PMID: 30722784 PMCID: PMC6364423 DOI: 10.1186/s13019-019-0850-x
Source DB: PubMed Journal: J Cardiothorac Surg ISSN: 1749-8090 Impact factor: 1.637
Main characteristics of the patients, pTNM-Classification 2017, 8th Edition
| Characteristics | Number of Patients (n) | Percentage |
|---|---|---|
| Tumor-localization | ||
| central | 53 | 26.2% |
| peripheral | 149 | 73.8% |
| Histology | ||
| adenocarcinoma | 117 | 57.4% |
| SCCa | 75 | 36.8% |
| others | 12 | 5.9% |
| Grading | ||
| In situ | 2 | 1% |
| G1 | 25 | 12.4% |
| G2 | 95 | 47.0% |
| G3 | 68 | 33.3% |
| G4 | 12 | 5.9% |
| pT-category | ||
| pTis | 2 | 1% |
| pT1 | 90 | 45.1% |
| pT1a | 10 | 4.9% |
| pT1b | 37 | 18.1% |
| pT1c | 43 | 21.1% |
| pT2 | 44 | 26.5 |
| pT2a | 39 | 19.1% |
| pT2b | 15 | 7.4% |
| pT3 | 35 | 17.2% |
| pT4 | 23 | 11.3 |
| pN-category | ||
| pN0 | 126 | 61.8% |
| pN1 | 33 | 16.2% |
| pN2 | 45 | 22% |
| pM-category | ||
| pM0 | 193 | 94.5% |
| pM1a | 5 | 2.5% |
| pM1b | 5 | 2.5% |
| pM1c | 1 | 0.5% |
| L-Status | ||
| L0 | 57 | 28.1% |
| L1 | 146 | 71.9% |
| V-Status | ||
| V0 | 165 | 81.3% |
| V1 | 38 | 18.7% |
aSCC Squamous cell carcinoma
Univariate Analysis of positive pulmonary and mediastinal lymph nodes (pN1+, pN2+)
| Variables | pN1- (%) | pN1+ (%) | pN2- (%) | pN2+ (%) | ||
|---|---|---|---|---|---|---|
| Sex | 0.148 | 0.627 | ||||
| male | 90 (63.4) | 52 (36.6) | 112 (78.9) | 30 (21.1) | ||
| female | 46 (74.2) | 16 (25.8) | 47 (75.8) | 15 (24.2) | ||
| Age | 0.298 | 0.237 | ||||
| ≤ 68 years | 68 (63) | 40 (37) | 88 (81.5) | 20 (81.5) | ||
| > 68 years | 68 (70.8) | 28 (29.2) | 71 (74.0) | 25 (21.2) | ||
| Tumor site | 0.067 | 0.783 | ||||
| right | 90 (71.4) | 36 (28.6) | 99 (78.6) | 27 (21.4) | ||
| left | 46 (59) | 32 (41) | 60 (76.9) | 18 (23.1) | ||
| Tumor localization | < 0.001 | 0.02 | ||||
| central | 25 (47.2) | 28 (52.8) | 36 (66.7) | 18 (33.3) | ||
| peripheral | 111 (74.5) | 38 (25.5) | 122 (81.9) | 27 (18.1) | ||
| Tumor size | 0.011 | 0.042 | ||||
| ≤ 3 cm | 77 (75.5) | 25 (24.5) | 86 (84.3) | 16 (15.7) | ||
| > 3 cm | 59 (57.8) | 43 (42.8) | 73 (71.6) | 29 (28.4) | ||
| Lobe distribution | 0.918 | 0.385 | ||||
| ULa | 85 (66.4) | 43 (33.6) | 97 (75.8) | 31 (24.2) | ||
| Non-UL | 51 (67.1) | 25 (32.9) | 62 (81.6) | 14 (18.4) | ||
| pT-category | 0.015 | 0.081 | ||||
| pT1 | 70 (77.8) | 20 (22.2) | 77 (85.6) | 13 (14.4) | ||
| pT2 | 33 (61.1) | 21 (38.9) | 40 (74.1) | 14 (25.9) | ||
| pT3 | 18 (51.4) | 17 (48.6) | 23 (65.7) | 12 (34.3) | ||
| pT4 | 13 (56.5) | 10 (43.5) | 17 (73.9) | 6 (26.1) | ||
| R-classification | 0.017 | 0.088 | ||||
| R0 | 130 (68.8) | 59 (31.2) | 150 (79.4) | 39 (20.6) | ||
| R1–2 | 5 (35.7) | 9 (64.3) | 8 (57.1) | 6 (42.9) | ||
| L-status | < 0.001 | < 0.001 | ||||
| L0 | 55 (96.5) | 2 (3.5) | 56 (98.2) | 1 (1.8) | ||
| L1 | 80 (54.8) | 66 (45.2) | 102 (69.9) | 44 (30.1) | ||
| V-status | 0.006 | 0.004 | ||||
| V0 | 117 (70.9) | 48 (29.1) | 135 (81.1) | 30 (18.2) | ||
| V | 18 (47.4) | 20 (52.6) | 23 (60.5) | 15 (39.5) | ||
| Pn-Status | 0.088 | 0.34 | ||||
| Pn0 | 131 (67.9) | 62 (32.1) | 149 (77.2) | 44 (22.8) | ||
| Pn1 | 4 (40.0) | 6 (60.0) | 9 (90.0) | 1 (10.0) | ||
| Histological tumor type | 0.214 | 0.646 | ||||
| Adeno-Ca.b | 84 (71.8) | 33 (28.2) | 94 (80.3) | 23 (19.7) | ||
| 56 (74.4) | 19 (25.6) | |||||
| SCCc | 45 (60.0) | 30 (40.0) | 9 (75.0) | 3 (25.0) | ||
| others | 7 (58.3) | 5 (41.7) | ||||
| Grading | 0.016 | 0.001 | ||||
| G1 | 25 (89.3) | 3 (10.7) | 27 (96.4) | 1 (3.6) | ||
| G2 | 64 (67.4) | 31 (32.6) | 79 (83.2) | 16 (16.8) | ||
| G3 | 39 (57.4) | 29 (42.6) | 43 (63.2) | 25 (36.8) | ||
| G4 | 7 (58.3) | 5 (41.7) | 9 (75.0) | 3 (25.0) | ||
aUL Upper lobe, bAdeno-Ca. Adenocarcinoma, cSCC Squamous cell carcinoma
Univariate Analysis of positive lymph nodes (pN0, pN+)
| Variables | pN0 (%) | pN+ (%) | |
|---|---|---|---|
| Sex | 0.397 | ||
| male | 85 (59.9) | 57 (40.1) | |
| female | 41 (66.1) | 21 (33.9) | |
| Age | 0.314 | ||
| ≤ 68 years | 63 (58.3) | 45 (41.7) | |
| > 68 years | 63 (65.6) | 33 (34.4) | |
| Tumor site | 0.067 | ||
| Right | 84 (66.7) | 42 (33.3) | |
| Left | 42 (53.8) | 36 (46.2) | |
| Tumor localization | < 0.001 | ||
| central | 22 (41.5) | 31 (58.5) | |
| peripheral | 104 (69.8) | 45 (30.2) | |
| Tumor size | < 0.001 | ||
| ≤ 3 cm | 76 (74.5) | 26 (25.5) | |
| > 3 cm | 50 (49) | 52 (51) | |
| Lobe distribution | 0.834 | ||
| UL a | 78 (60.9) | 50 (39.1) | |
| Non-UL | 40 (62.5) | 24 (37.5) | |
| Number of dissected LN b | 0.005 | ||
| pT-category | 0.001 | ||
| pT1 | 69 (76.7) | 21 (23.3) | |
| pT2 | 27 (50.9) | 26 (49.1) | |
| pT3 | 17 (47.2) | 19 (52.8) | |
| pT4 | 11 (47.8) | 12 (52.2) | |
| R-classification | 0.048 | ||
| R0 | 120 (96.0) | 5 (4.0) | |
| R1–2 | 69 (88.5) | 9 (11.5) | |
| L-status | < 0.001 | ||
| L0 | 54 (94.7) | 3 (5.3) | |
| L1 | 71 (48.6) | 75 (51.4) | |
| V-status | 0.001 | ||
| V0 | 111 (67.3) | 54 (32.7) | |
| V1 | 14 (36.8) | 24 (63.2) | |
| Pn-status | 0.188 | ||
| Pn0 | 121 (96.8) | 4 (3.2) | |
| Pn1 | 72 (92.3) | 6 (7.7) | |
| Histological tumor type | 0.141 | ||
| Adeno-Ca.b | 79 (67.5) | 38 (32.5) | |
| SCCc | 41 (54.7) | 34 (45.3) | |
| others | 6 (50.0) | 6 (50.0) | |
| Grading | 0.005 | ||
| G1 | 22 (88.0) | 3 (12.0) | |
| G2 | 60 (63.2) | 35 (36.8) | |
| G3 | 34 (50.0) | 34 (50.0) | |
| G4 | 6 (50.0) | 6 (50.0) | |
aUL Upper lobe, bAdeno-Ca. Adenocarcinoma, cSCC Squamous cell carcinoma