Literature DB >> 30721968

Disentangling the genetics of lean mass.

David Karasik1,2, M Carola Zillikens3,4, Yi-Hsiang Hsu1,5,6, Ali Aghdassi7, Kristina Akesson8,9, Najaf Amin10, Inês Barroso11,12,13, David A Bennett14, Lars Bertram15, Murielle Bochud16, Ingrid B Borecki17,18, Linda Broer3,10, Aron S Buchman14, Liisa Byberg19, Harry Campbell20, Natalia Campos-Obando3, Jane A Cauley21, Peggy M Cawthon22, John C Chambers23,24,25,26, Zhao Chen27, Nam H Cho28, Hyung Jin Choi29,30,31, Wen-Chi Chou1,32, Steven R Cummings22, Lisette C P G M de Groot33, Phillip L De Jager34,35, Ilja Demuth36,37, Luda Diatchenko38,39, Michael J Econs40, Gudny Eiriksdottir41, Anke W Enneman3, Joel Eriksson42, Johan G Eriksson43,44,45,46, Karol Estrada3,10,47, Daniel S Evans22, Mary F Feitosa17, Mao Fu48, Christian Gieger49,50,51, Harald Grallert49,50,52,53,54, Vilmundur Gudnason41,55, Launer J Lenore56, Caroline Hayward57, Albert Hofman3,4, Georg Homuth58, Kim M Huffman59, Lise B Husted60, Thomas Illig49,61, Erik Ingelsson62, Till Ittermann63, John-Olov Jansson64, Toby Johnson16,65,66, Reiner Biffar67, Joanne M Jordan68, Antti Jula43, Magnus Karlsson8,9, Kay-Tee Khaw69, Tuomas O Kilpeläinen70,71,72, Norman Klopp49,73, Jacqueline S L Kloth3, Daniel L Koller40, Jaspal S Kooner23,25,74, William E Kraus75, Stephen Kritchevsky76, Zoltán Kutalik16,66, Teemu Kuulasmaa77, Johanna Kuusisto77, Markku Laakso77, Jari Lahti78, Thomas Lang79, Bente L Langdahl60, Markus M Lerch7, Joshua R Lewis80,81, Christina Lill82, Lars Lind83, Cecilia Lindgren84, Yongmei Liu85, Gregory Livshits86,87, Östen Ljunggren83, Ruth J F Loos72,88,89,90, Mattias Lorentzon91, Jian'an Luan72, Robert N Luben71, Ida Malkin86, Fiona E McGuigan8, Carolina Medina-Gomez3,10, Thomas Meitinger92,93, Håkan Melhus83, Dan Mellström42, Karl Michaëlsson19, Braxton D Mitchell48,94, Andrew P Morris84,95, Leif Mosekilde60, Maria Nethander42, Anne B Newman21, Jeffery R O'Connell48, Ben A Oostra96,97, Eric S Orwoll98, Aarno Palotie99,100, Munro Peacock40, Markus Perola43,101,102, Annette Peters49,50, Richard L Prince80,103, Bruce M Psaty104,105, Katri Räikkönen106, Stuart H Ralston107, Samuli Ripatti11,99,108, Fernando Rivadeneira3,4,10, John A Robbins109, Jerome I Rotter110, Igor Rudan21, Veikko Salomaa43, Suzanne Satterfield111, Sabine Schipf63, Chan Soo Shin29, Albert V Smith41,55, Shad B Smith112, Nicole Soranzo11, Timothy D Spector87, Alena Stancáková77, Kari Stefansson55,113, Elisabeth Steinhagen-Thiessen36, Lisette Stolk3,4, Elizabeth A Streeten48,94, Unnur Styrkarsdottir113, Karin M A Swart114, Patricia Thompson115, Cynthia A Thomson27, Gudmar Thorleifsson113, Unnur Thorsteinsdottir55,113, Emmi Tikkanen43,99, Gregory J Tranah22, André G Uitterlinden3,4,10, Cornelia M van Duijn10,97, Natasja M van Schoor114, Liesbeth Vandenput42, Peter Vollenweider116, Henry Völzke63, Jean Wactawski-Wende117, Mark Walker118, Nicholas J Wareham70, Dawn Waterworth119, Michael N Weedon120, H-Erich Wichmann50,121,122, Elisabeth Widen99, Frances M K Williams87, James F Wilson20, Nicole C Wright123, Laura M Yerges-Armstrong48,119, Lei Yu14, Weihua Zhang23,25, Jing Hua Zhao70, Yanhua Zhou124, Carrie M Nielson98, Tamara B Harris56, Serkalem Demissie124, Douglas P Kiel1,5, Claes Ohlsson42.   

Abstract

Background: Lean body mass (LM) plays an important role in mobility and metabolic function. We previously identified five loci associated with LM adjusted for fat mass in kilograms. Such an adjustment may reduce the power to identify genetic signals having an association with both lean mass and fat mass.
Objectives: To determine the impact of different fat mass adjustments on genetic architecture of LM and identify additional LM loci.
Methods: We performed genome-wide association analyses for whole-body LM (20 cohorts of European ancestry with n = 38,292) measured using dual-energy X-ray absorptiometry) or bioelectrical impedance analysis, adjusted for sex, age, age2, and height with or without fat mass adjustments (Model 1 no fat adjustment; Model 2 adjustment for fat mass as a percentage of body mass; Model 3 adjustment for fat mass in kilograms).
Results: Seven single-nucleotide polymorphisms (SNPs) in separate loci, including one novel LM locus (TNRC6B), were successfully replicated in an additional 47,227 individuals from 29 cohorts. Based on the strengths of the associations in Model 1 vs Model 3, we divided the LM loci into those with an effect on both lean mass and fat mass in the same direction and refer to those as "sumo wrestler" loci (FTO and MC4R). In contrast, loci with an impact specifically on LM were termed "body builder" loci (VCAN and ADAMTSL3). Using existing available genome-wide association study databases, LM increasing alleles of SNPs in sumo wrestler loci were associated with an adverse metabolic profile, whereas LM increasing alleles of SNPs in "body builder" loci were associated with metabolic protection. Conclusions: In conclusion, we identified one novel LM locus (TNRC6B). Our results suggest that a genetically determined increase in lean mass might exert either harmful or protective effects on metabolic traits, depending on its relation to fat mass.

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Year:  2019        PMID： 30721968      PMCID： PMC6500901          DOI： 10.1093/ajcn/nqy272

Source DB:  PubMed          Journal:  Am J Clin Nutr        ISSN： 0002-9165            Impact factor:   7.045


  30 in total

1.  Evaluation of the Usefulness of Consensus Definitions of Sarcopenia in Older Men: Results from the Observational Osteoporotic Fractures in Men Cohort Study.

Authors:  Peggy M Cawthon; Terri L Blackwell; Jane Cauley; Deborah M Kado; Elizabeth Barrett-Connor; Christine G Lee; Andrew R Hoffman; Michael Nevitt; Marcia L Stefanick; Nancy E Lane; Kristine E Ensrud; Steven R Cummings; Eric S Orwoll
Journal:  J Am Geriatr Soc       Date:  2015-10-27       Impact factor: 5.562

2.  A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids.

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3.  Height and weight at menarche and a hypothesis of critical body weights and adolescent events.

Authors:  R E Frisch; R Revelle
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4.  Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity.

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Journal:  Hum Mol Genet       Date:  2013-09-23       Impact factor: 6.150

5.  Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.

Authors:  Karol Estrada; Unnur Styrkarsdottir; Evangelos Evangelou; Yi-Hsiang Hsu; Emma L Duncan; Evangelia E Ntzani; Ling Oei; Omar M E Albagha; Najaf Amin; John P Kemp; Daniel L Koller; Guo Li; Ching-Ti Liu; Ryan L Minster; Alireza Moayyeri; Liesbeth Vandenput; Dana Willner; Su-Mei Xiao; Laura M Yerges-Armstrong; Hou-Feng Zheng; Nerea Alonso; Joel Eriksson; Candace M Kammerer; Stephen K Kaptoge; Paul J Leo; Gudmar Thorleifsson; Scott G Wilson; James F Wilson; Ville Aalto; Markku Alen; Aaron K Aragaki; Thor Aspelund; Jacqueline R Center; Zoe Dailiana; David J Duggan; Melissa Garcia; Natàlia Garcia-Giralt; Sylvie Giroux; Göran Hallmans; Lynne J Hocking; Lise Bjerre Husted; Karen A Jameson; Rita Khusainova; Ghi Su Kim; Charles Kooperberg; Theodora Koromila; Marcin Kruk; Marika Laaksonen; Andrea Z Lacroix; Seung Hun Lee; Ping C Leung; Joshua R Lewis; Laura Masi; Simona Mencej-Bedrac; Tuan V Nguyen; Xavier Nogues; Millan S Patel; Janez Prezelj; Lynda M Rose; Serena Scollen; Kristin Siggeirsdottir; Albert V Smith; Olle Svensson; Stella Trompet; Olivia Trummer; Natasja M van Schoor; Jean Woo; Kun Zhu; Susana Balcells; Maria Luisa Brandi; Brendan M Buckley; Sulin Cheng; Claus Christiansen; Cyrus Cooper; George Dedoussis; Ian Ford; Morten Frost; David Goltzman; Jesús González-Macías; Mika Kähönen; Magnus Karlsson; Elza Khusnutdinova; Jung-Min Koh; Panagoula Kollia; Bente Lomholt Langdahl; William D Leslie; Paul Lips; Östen Ljunggren; Roman S Lorenc; Janja Marc; Dan Mellström; Barbara Obermayer-Pietsch; José M Olmos; Ulrika Pettersson-Kymmer; David M Reid; José A Riancho; Paul M Ridker; François Rousseau; P Eline Slagboom; Nelson L S Tang; Roser Urreizti; Wim Van Hul; Jorma Viikari; María T Zarrabeitia; Yurii S Aulchenko; Martha Castano-Betancourt; Elin Grundberg; Lizbeth Herrera; Thorvaldur Ingvarsson; Hrefna Johannsdottir; Tony Kwan; Rui Li; Robert Luben; Carolina Medina-Gómez; Stefan Th Palsson; Sjur Reppe; Jerome I Rotter; Gunnar Sigurdsson; Joyce B J van Meurs; Dominique Verlaan; Frances M K Williams; Andrew R Wood; Yanhua Zhou; Kaare M Gautvik; Tomi Pastinen; Soumya Raychaudhuri; Jane A Cauley; Daniel I Chasman; Graeme R Clark; Steven R Cummings; Patrick Danoy; Elaine M Dennison; Richard Eastell; John A Eisman; Vilmundur Gudnason; Albert Hofman; Rebecca D Jackson; Graeme Jones; J Wouter Jukema; Kay-Tee Khaw; Terho Lehtimäki; Yongmei Liu; Mattias Lorentzon; Eugene McCloskey; Braxton D Mitchell; Kannabiran Nandakumar; Geoffrey C Nicholson; Ben A Oostra; Munro Peacock; Huibert A P Pols; Richard L Prince; Olli Raitakari; Ian R Reid; John Robbins; Philip N Sambrook; Pak Chung Sham; Alan R Shuldiner; Frances A Tylavsky; Cornelia M van Duijn; Nick J Wareham; L Adrienne Cupples; Michael J Econs; David M Evans; Tamara B Harris; Annie Wai Chee Kung; Bruce M Psaty; Jonathan Reeve; Timothy D Spector; Elizabeth A Streeten; M Carola Zillikens; Unnur Thorsteinsdottir; Claes Ohlsson; David Karasik; J Brent Richards; Matthew A Brown; Kari Stefansson; André G Uitterlinden; Stuart H Ralston; John P A Ioannidis; Douglas P Kiel; Fernando Rivadeneira
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Journal:  Nat Commun       Date:  2014-10-24       Impact factor: 14.919

7.  GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium.

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8.  Discovery and refinement of loci associated with lipid levels.

Authors:  Cristen J Willer; Ellen M Schmidt; Sebanti Sengupta; Michael Boehnke; Panos Deloukas; Sekar Kathiresan; Karen L Mohlke; Erik Ingelsson; Gonçalo R Abecasis; Gina M Peloso; Stefan Gustafsson; Stavroula Kanoni; Andrea Ganna; Jin Chen; Martin L Buchkovich; Samia Mora; Jacques S Beckmann; Jennifer L Bragg-Gresham; Hsing-Yi Chang; Ayşe Demirkan; Heleen M Den Hertog; Ron Do; Louise A Donnelly; Georg B Ehret; Tõnu Esko; Mary F Feitosa; Teresa Ferreira; Krista Fischer; Pierre Fontanillas; Ross M Fraser; Daniel F Freitag; Deepti Gurdasani; Kauko Heikkilä; Elina Hyppönen; Aaron Isaacs; Anne U Jackson; Åsa Johansson; Toby Johnson; Marika Kaakinen; Johannes Kettunen; Marcus E Kleber; Xiaohui Li; Jian'an Luan; Leo-Pekka Lyytikäinen; Patrik K E Magnusson; Massimo Mangino; Evelin Mihailov; May E Montasser; Martina Müller-Nurasyid; Ilja M Nolte; Jeffrey R O'Connell; Cameron D Palmer; Markus Perola; Ann-Kristin Petersen; Serena Sanna; Richa Saxena; Susan K Service; Sonia Shah; Dmitry Shungin; Carlo Sidore; Ci Song; Rona J Strawbridge; Ida Surakka; Toshiko Tanaka; Tanya M Teslovich; Gudmar Thorleifsson; Evita G Van den Herik; Benjamin F Voight; Kelly A Volcik; Lindsay L Waite; Andrew Wong; Ying Wu; Weihua Zhang; Devin Absher; Gershim Asiki; Inês Barroso; Latonya F Been; Jennifer L Bolton; Lori L Bonnycastle; Paolo Brambilla; Mary S Burnett; Giancarlo Cesana; Maria Dimitriou; Alex S F Doney; Angela Döring; Paul Elliott; Stephen E Epstein; Gudmundur Ingi Eyjolfsson; Bruna Gigante; Mark O Goodarzi; Harald Grallert; Martha L Gravito; Christopher J Groves; Göran Hallmans; Anna-Liisa Hartikainen; Caroline Hayward; Dena Hernandez; Andrew A Hicks; Hilma Holm; Yi-Jen Hung; Thomas Illig; Michelle R Jones; Pontiano Kaleebu; John J P Kastelein; Kay-Tee Khaw; Eric Kim; Norman Klopp; Pirjo Komulainen; Meena Kumari; Claudia Langenberg; Terho Lehtimäki; Shih-Yi Lin; Jaana Lindström; Ruth J F Loos; François Mach; Wendy L McArdle; Christa Meisinger; Braxton D Mitchell; Gabrielle Müller; Ramaiah Nagaraja; Narisu Narisu; Tuomo V M Nieminen; Rebecca N Nsubuga; Isleifur Olafsson; Ken K Ong; Aarno Palotie; Theodore Papamarkou; Cristina Pomilla; Anneli Pouta; Daniel J Rader; Muredach P Reilly; Paul M Ridker; Fernando Rivadeneira; Igor Rudan; Aimo Ruokonen; Nilesh Samani; Hubert Scharnagl; Janet Seeley; Kaisa Silander; Alena Stančáková; Kathleen Stirrups; Amy J Swift; Laurence Tiret; Andre G Uitterlinden; L Joost van Pelt; Sailaja Vedantam; Nicholas Wainwright; Cisca Wijmenga; Sarah H Wild; Gonneke Willemsen; Tom Wilsgaard; James F Wilson; Elizabeth H Young; Jing Hua Zhao; Linda S Adair; Dominique Arveiler; Themistocles L Assimes; Stefania Bandinelli; Franklyn Bennett; Murielle Bochud; Bernhard O Boehm; Dorret I Boomsma; Ingrid B Borecki; Stefan R Bornstein; Pascal Bovet; Michel Burnier; Harry Campbell; Aravinda Chakravarti; John C Chambers; Yii-Der Ida Chen; Francis S Collins; Richard S Cooper; John Danesh; George Dedoussis; Ulf de Faire; Alan B Feranil; Jean Ferrières; Luigi Ferrucci; Nelson B Freimer; Christian Gieger; Leif C Groop; Vilmundur Gudnason; Ulf Gyllensten; Anders Hamsten; Tamara B Harris; Aroon Hingorani; Joel N Hirschhorn; Albert Hofman; G Kees Hovingh; Chao Agnes Hsiung; Steve E Humphries; Steven C Hunt; Kristian Hveem; Carlos Iribarren; Marjo-Riitta Järvelin; Antti Jula; Mika Kähönen; Jaakko Kaprio; Antero Kesäniemi; Mika Kivimaki; Jaspal S Kooner; Peter J Koudstaal; Ronald M Krauss; Diana Kuh; Johanna Kuusisto; Kirsten O Kyvik; Markku Laakso; Timo A Lakka; Lars Lind; Cecilia M Lindgren; Nicholas G Martin; Winfried März; Mark I McCarthy; Colin A McKenzie; Pierre Meneton; Andres Metspalu; Leena Moilanen; Andrew D Morris; Patricia B Munroe; Inger Njølstad; Nancy L Pedersen; Chris Power; Peter P Pramstaller; Jackie F Price; Bruce M Psaty; Thomas Quertermous; Rainer Rauramaa; Danish Saleheen; Veikko Salomaa; Dharambir K Sanghera; Jouko Saramies; Peter E H Schwarz; Wayne H-H Sheu; Alan R Shuldiner; Agneta Siegbahn; Tim D Spector; Kari Stefansson; David P Strachan; Bamidele O Tayo; Elena Tremoli; Jaakko Tuomilehto; Matti Uusitupa; Cornelia M van Duijn; Peter Vollenweider; Lars Wallentin; Nicholas J Wareham; John B Whitfield; Bruce H R Wolffenbuttel; Jose M Ordovas; Eric Boerwinkle; Colin N A Palmer; Unnur Thorsteinsdottir; Daniel I Chasman; Jerome I Rotter; Paul W Franks; Samuli Ripatti; L Adrienne Cupples; Manjinder S Sandhu; Stephen S Rich
Journal:  Nat Genet       Date:  2013-10-06       Impact factor: 38.330

9.  New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

Authors:  Yingchang Lu; Felix R Day; Stefan Gustafsson; Martin L Buchkovich; Jianbo Na; Veronique Bataille; Diana L Cousminer; Zari Dastani; Alexander W Drong; Tõnu Esko; David M Evans; Mario Falchi; Mary F Feitosa; Teresa Ferreira; Åsa K Hedman; Robin Haring; Pirro G Hysi; Mark M Iles; Anne E Justice; Stavroula Kanoni; Vasiliki Lagou; Rui Li; Xin Li; Adam Locke; Chen Lu; Reedik Mägi; John R B Perry; Tune H Pers; Qibin Qi; Marianna Sanna; Ellen M Schmidt; William R Scott; Dmitry Shungin; Alexander Teumer; Anna A E Vinkhuyzen; Ryan W Walker; Harm-Jan Westra; Mingfeng Zhang; Weihua Zhang; Jing Hua Zhao; Zhihong Zhu; Uzma Afzal; Tarunveer Singh Ahluwalia; Stephan J L Bakker; Claire Bellis; Amélie Bonnefond; Katja Borodulin; Aron S Buchman; Tommy Cederholm; Audrey C Choh; Hyung Jin Choi; Joanne E Curran; Lisette C P G M de Groot; Philip L De Jager; Rosalie A M Dhonukshe-Rutten; Anke W Enneman; Elodie Eury; Daniel S Evans; Tom Forsen; Nele Friedrich; Frédéric Fumeron; Melissa E Garcia; Simone Gärtner; Bok-Ghee Han; Aki S Havulinna; Caroline Hayward; Dena Hernandez; Hans Hillege; Till Ittermann; Jack W Kent; Ivana Kolcic; Tiina Laatikainen; Jari Lahti; Irene Mateo Leach; Christine G Lee; Jong-Young Lee; Tian Liu; Youfang Liu; Stéphane Lobbens; Marie Loh; Leo-Pekka Lyytikäinen; Carolina Medina-Gomez; Karl Michaëlsson; Mike A Nalls; Carrie M Nielson; Laticia Oozageer; Laura Pascoe; Lavinia Paternoster; Ozren Polašek; Samuli Ripatti; Mark A Sarzynski; Chan Soo Shin; Nina Smolej Narančić; Dominik Spira; Priya Srikanth; Elisabeth Steinhagen-Thiessen; Yun Ju Sung; Karin M A Swart; Leena Taittonen; Toshiko Tanaka; Emmi Tikkanen; Nathalie van der Velde; Natasja M van Schoor; Niek Verweij; Alan F Wright; Lei Yu; Joseph M Zmuda; Niina Eklund; Terrence Forrester; Niels Grarup; Anne U Jackson; Kati Kristiansson; Teemu Kuulasmaa; Johanna Kuusisto; Peter Lichtner; Jian'an Luan; Anubha Mahajan; Satu Männistö; Cameron D Palmer; Janina S Ried; Robert A Scott; Alena Stancáková; Peter J Wagner; Ayse Demirkan; Angela Döring; Vilmundur Gudnason; Douglas P Kiel; Brigitte Kühnel; Massimo Mangino; Barbara Mcknight; Cristina Menni; Jeffrey R O'Connell; Ben A Oostra; Alan R Shuldiner; Kijoung Song; Liesbeth Vandenput; Cornelia M van Duijn; Peter Vollenweider; Charles C White; Michael Boehnke; Yvonne Boettcher; Richard S Cooper; Nita G Forouhi; Christian Gieger; Harald Grallert; Aroon Hingorani; Torben Jørgensen; Pekka Jousilahti; Mika Kivimaki; Meena Kumari; Markku Laakso; Claudia Langenberg; Allan Linneberg; Amy Luke; Colin A Mckenzie; Aarno Palotie; Oluf Pedersen; Annette Peters; Konstantin Strauch; Bamidele O Tayo; Nicholas J Wareham; David A Bennett; Lars Bertram; John Blangero; Matthias Blüher; Claude Bouchard; Harry Campbell; Nam H Cho; Steven R Cummings; Stefan A Czerwinski; Ilja Demuth; Rahel Eckardt; Johan G Eriksson; Luigi Ferrucci; Oscar H Franco; Philippe Froguel; Ron T Gansevoort; Torben Hansen; Tamara B Harris; Nicholas Hastie; Markku Heliövaara; Albert Hofman; Joanne M Jordan; Antti Jula; Mika Kähönen; Eero Kajantie; Paul B Knekt; Seppo Koskinen; Peter Kovacs; Terho Lehtimäki; Lars Lind; Yongmei Liu; Eric S Orwoll; Clive Osmond; Markus Perola; Louis Pérusse; Olli T Raitakari; Tuomo Rankinen; D C Rao; Treva K Rice; Fernando Rivadeneira; Igor Rudan; Veikko Salomaa; Thorkild I A Sørensen; Michael Stumvoll; Anke Tönjes; Bradford Towne; Gregory J Tranah; Angelo Tremblay; André G Uitterlinden; Pim van der Harst; Erkki Vartiainen; Jorma S Viikari; Veronique Vitart; Marie-Claude Vohl; Henry Völzke; Mark Walker; Henri Wallaschofski; Sarah Wild; James F Wilson; Loïc Yengo; D Timothy Bishop; Ingrid B Borecki; John C Chambers; L Adrienne Cupples; Abbas Dehghan; Panos Deloukas; Ghazaleh Fatemifar; Caroline Fox; Terrence S Furey; Lude Franke; Jiali Han; David J Hunter; Juha Karjalainen; Fredrik Karpe; Robert C Kaplan; Jaspal S Kooner; Mark I McCarthy; Joanne M Murabito; Andrew P Morris; Julia A N Bishop; Kari E North; Claes Ohlsson; Ken K Ong; Inga Prokopenko; J Brent Richards; Eric E Schadt; Tim D Spector; Elisabeth Widén; Cristen J Willer; Jian Yang; Erik Ingelsson; Karen L Mohlke; Joel N Hirschhorn; John Andrew Pospisilik; M Carola Zillikens; Cecilia Lindgren; Tuomas Oskari Kilpeläinen; Ruth J F Loos
Journal:  Nat Commun       Date:  2016-02-01       Impact factor: 14.919

10.  Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.

Authors:  Andrew P Morris; Benjamin F Voight; Tanya M Teslovich; Teresa Ferreira; Ayellet V Segrè; Valgerdur Steinthorsdottir; Rona J Strawbridge; Hassan Khan; Harald Grallert; Anubha Mahajan; Inga Prokopenko; Hyun Min Kang; Christian Dina; Tonu Esko; Ross M Fraser; Stavroula Kanoni; Ashish Kumar; Vasiliki Lagou; Claudia Langenberg; Jian'an Luan; Cecilia M Lindgren; Martina Müller-Nurasyid; Sonali Pechlivanis; N William Rayner; Laura J Scott; Steven Wiltshire; Loic Yengo; Leena Kinnunen; Elizabeth J Rossin; Soumya Raychaudhuri; Andrew D Johnson; Antigone S Dimas; Ruth J F Loos; Sailaja Vedantam; Han Chen; Jose C Florez; Caroline Fox; Ching-Ti Liu; Denis Rybin; David J Couper; Wen Hong L Kao; Man Li; Marilyn C Cornelis; Peter Kraft; Qi Sun; Rob M van Dam; Heather M Stringham; Peter S Chines; Krista Fischer; Pierre Fontanillas; Oddgeir L Holmen; Sarah E Hunt; Anne U Jackson; Augustine Kong; Robert Lawrence; Julia Meyer; John R B Perry; Carl G P Platou; Simon Potter; Emil Rehnberg; Neil Robertson; Suthesh Sivapalaratnam; Alena Stančáková; Kathleen Stirrups; Gudmar Thorleifsson; Emmi Tikkanen; Andrew R Wood; Peter Almgren; Mustafa Atalay; Rafn Benediktsson; Lori L Bonnycastle; Noël Burtt; Jason Carey; Guillaume Charpentier; Andrew T Crenshaw; Alex S F Doney; Mozhgan Dorkhan; Sarah Edkins; Valur Emilsson; Elodie Eury; Tom Forsen; Karl Gertow; Bruna Gigante; George B Grant; Christopher J Groves; Candace Guiducci; Christian Herder; Astradur B Hreidarsson; Jennie Hui; Alan James; Anna Jonsson; Wolfgang Rathmann; Norman Klopp; Jasmina Kravic; Kaarel Krjutškov; Cordelia Langford; Karin Leander; Eero Lindholm; Stéphane Lobbens; Satu Männistö; Ghazala Mirza; Thomas W Mühleisen; Bill Musk; Melissa Parkin; Loukianos Rallidis; Jouko Saramies; Bengt Sennblad; Sonia Shah; Gunnar Sigurðsson; Angela Silveira; Gerald Steinbach; Barbara Thorand; Joseph Trakalo; Fabrizio Veglia; Roman Wennauer; Wendy Winckler; Delilah Zabaneh; Harry Campbell; Cornelia van Duijn; Andre G Uitterlinden; Albert Hofman; Eric Sijbrands; Goncalo R Abecasis; Katharine R Owen; Eleftheria Zeggini; Mieke D Trip; Nita G Forouhi; Ann-Christine Syvänen; Johan G Eriksson; Leena Peltonen; Markus M Nöthen; Beverley Balkau; Colin N A Palmer; Valeriya Lyssenko; Tiinamaija Tuomi; Bo Isomaa; David J Hunter; Lu Qi; Alan R Shuldiner; Michael Roden; Ines Barroso; Tom Wilsgaard; John Beilby; Kees Hovingh; Jackie F Price; James F Wilson; Rainer Rauramaa; Timo A Lakka; Lars Lind; George Dedoussis; Inger Njølstad; Nancy L Pedersen; Kay-Tee Khaw; Nicholas J Wareham; Sirkka M Keinanen-Kiukaanniemi; Timo E Saaristo; Eeva Korpi-Hyövälti; Juha Saltevo; Markku Laakso; Johanna Kuusisto; Andres Metspalu; Francis S Collins; Karen L Mohlke; Richard N Bergman; Jaakko Tuomilehto; Bernhard O Boehm; Christian Gieger; Kristian Hveem; Stephane Cauchi; Philippe Froguel; Damiano Baldassarre; Elena Tremoli; Steve E Humphries; Danish Saleheen; John Danesh; Erik Ingelsson; Samuli Ripatti; Veikko Salomaa; Raimund Erbel; Karl-Heinz Jöckel; Susanne Moebus; Annette Peters; Thomas Illig; Ulf de Faire; Anders Hamsten; Andrew D Morris; Peter J Donnelly; Timothy M Frayling; Andrew T Hattersley; Eric Boerwinkle; Olle Melander; Sekar Kathiresan; Peter M Nilsson; Panos Deloukas; Unnur Thorsteinsdottir; Leif C Groop; Kari Stefansson; Frank Hu; James S Pankow; Josée Dupuis; James B Meigs; David Altshuler; Michael Boehnke; Mark I McCarthy
Journal:  Nat Genet       Date:  2012-08-12       Impact factor: 38.330
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  14 in total

1.  Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2.

Authors:  Ana I Hernandez Cordero; Natalia M Gonzales; Clarissa C Parker; Greta Sokolof; David J Vandenbergh; Riyan Cheng; Mark Abney; Andrew Sko; Alex Douglas; Abraham A Palmer; Jennifer S Gregory; Arimantas Lionikas
Journal:  Am J Hum Genet       Date:  2019-11-21       Impact factor: 11.025

2.  Associations between genetic loci related to lean mass and body composition in type 2 diabetes.

Authors:  Tatsuro Minohara; Shinsuke Noso; Naru Babaya; Yoshihisa Hiromine; Yasunori Taketomo; Fumimaru Niwano; Yukako Makutani; Sawa Yoshida; Sara Yasutake; Shuzo Imamura; Hiroshi Ikegami
Journal:  Geriatr Gerontol Int       Date:  2021-08-14       Impact factor: 3.387

3.  Effect of Anti-Osteoporotic Treatments on Circulating and Bone MicroRNA Patterns in Osteopenic ZDF Rats.

Authors:  David Carro Vázquez; Lejla Emini; Martina Rauner; Christine Hofbauer; Johannes Grillari; Andreas B Diendorfer; Richard Eastell; Lorenz C Hofbauer; Matthias Hackl
Journal:  Int J Mol Sci       Date:  2022-06-10       Impact factor: 6.208

4.  Targeted genotype analyses of GWAS-derived lean body mass and handgrip strength-associated single-nucleotide polymorphisms in elite master athletes.

Authors:  Hannah Crossland; Jessica Piasecki; Daniel McCormick; Bethan E Phillips; Daniel J Wilkinson; Kenneth Smith; Jamie S McPhee; Mathew Piasecki; Philip J Atherton
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2020-06-24       Impact factor: 3.619

Review 5.  Body Composition Measurements from Birth through 5 Years: Challenges, Gaps, and Existing & Emerging Technologies-A National Institutes of Health workshop.

Authors:  Dympna Gallagher; Aline Andres; David A Fields; William J Evans; Robert Kuczmarski; William L Lowe; Julie C Lumeng; Emily Oken; John A Shepherd; Shumei Sun; Steven B Heymsfield
Journal:  Obes Rev       Date:  2020-04-20       Impact factor: 9.213

Review 6.  It's Not All Sunshine: Non-sun-related Melanoma Risk-factors.

Authors:  Veronique Bataille
Journal:  Acta Derm Venereol       Date:  2020-06-03       Impact factor: 3.875

Review 7.  Genetics of Bone and Muscle Interactions in Humans.

Authors:  Katerina Trajanoska; Fernando Rivadeneira; Douglas P Kiel; David Karasik
Journal:  Curr Osteoporos Rep       Date:  2019-04       Impact factor: 5.096

Review 8.  Zebrafish models of sarcopenia.

Authors:  Alon Daya; Rajashekar Donaka; David Karasik
Journal:  Dis Model Mech       Date:  2020-03-30       Impact factor: 5.758

9.  Disentangling the genetics of sarcopenia: prioritization of NUDT3 and KLF5 as genes for lean mass & HLA-DQB1-AS1 for hand grip strength with the associated enhancing SNPs & a scoring system.

Authors:  Abhishek Narain Singh; Bili Gasman
Journal:  BMC Med Genet       Date:  2020-02-24       Impact factor: 2.103

10.  Gene Network of Susceptibility to Atypical Femoral Fractures Related to Bisphosphonate Treatment.

Authors:  Natalia Garcia-Giralt; Neus Roca-Ayats; Josep F Abril; Nuria Martinez-Gil; Diana Ovejero; Santos Castañeda; Xavier Nogues; Daniel Grinberg; Susanna Balcells; Raquel Rabionet
Journal:  Genes (Basel)       Date:  2022-01-14       Impact factor: 4.096
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