Chung-Hsin Tsai1,2, Po-Sheng Yang1, Jie-Jen Lee1, Tsang-Pai Liu1,2, Chi-Yu Kuo1, Shih-Ping Cheng1,3. 1. 1 Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan. 2. 2 Mackay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan. 3. 3 Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Abstract
OBJECTIVE: The current guidelines recommend that potassium iodide be given in the immediate preoperative period for patients with Graves' disease who are undergoing thyroidectomy. Nonetheless, the evidence behind this recommendation is tenuous. The purpose of this study is to clarify the benefits of preoperative iodine administration from published comparative studies. DATA SOURCES: We searched PubMed, Embase, Cochrane, and CINAHL from 1980 to June 2018. REVIEW METHODS: Studies were included that compared preoperative iodine administration and no premedication before thyroidectomy. For the meta-analysis, studies were pooled with the random-effects model. RESULTS: A total of 510 patients were divided into the iodine (n = 223) and control (n = 287) groups from 9 selected studies. Preoperative iodine administration was significantly associated with decreased thyroid vascularity and intraoperative blood loss. Significant heterogeneity was present among studies. We found no significant difference in thyroid volume or operative time. Furthermore, the meta-analysis showed no difference in the risk of postoperative complications, including vocal cord palsy, hypoparathyroidism/hypocalcemia, and hemorrhage or hematoma after thyroidectomy. CONCLUSION: Preoperative iodine administration decreases thyroid vascularity and intraoperative blood loss. Nonetheless, it does not translate to more clinically meaningful differences in terms of operative time and postoperative complications.
OBJECTIVE: The current guidelines recommend that potassium iodide be given in the immediate preoperative period for patients with Graves' disease who are undergoing thyroidectomy. Nonetheless, the evidence behind this recommendation is tenuous. The purpose of this study is to clarify the benefits of preoperative iodine administration from published comparative studies. DATA SOURCES: We searched PubMed, Embase, Cochrane, and CINAHL from 1980 to June 2018. REVIEW METHODS: Studies were included that compared preoperative iodine administration and no premedication before thyroidectomy. For the meta-analysis, studies were pooled with the random-effects model. RESULTS: A total of 510 patients were divided into the iodine (n = 223) and control (n = 287) groups from 9 selected studies. Preoperative iodine administration was significantly associated with decreased thyroid vascularity and intraoperative blood loss. Significant heterogeneity was present among studies. We found no significant difference in thyroid volume or operative time. Furthermore, the meta-analysis showed no difference in the risk of postoperative complications, including vocal cord palsy, hypoparathyroidism/hypocalcemia, and hemorrhage or hematoma after thyroidectomy. CONCLUSION: Preoperative iodine administration decreases thyroid vascularity and intraoperative blood loss. Nonetheless, it does not translate to more clinically meaningful differences in terms of operative time and postoperative complications.
Authors: José Luis Muñoz de Nova; Guzmán Franch-Arcas; Gina Paola Mejía-Abril; María Eugenia Flores-Ruiz; Nuria Muñoz-Pérez; Elena Pintos-Sánchez; Francisco Javier Guadarrama González; Álvaro Valdés de Anca; Enrique Mercader-Cidoncha; Aitor de la Quintana-Basarrate; Irene Osorio-Silla; Susana Ros-López; Lander Gallego-Otaegui; Elena Santos-Molina; Concepción Martínez-Nieto; Elena Gamborino-Caramés; Mariano Artés-Caselles; Leyre Lorente-Poch; Maitane García-Carrillo; Pablo Moreno-Llorente; Consuelo Marín-Velarde; Joaquín Ortega-Serrano; Juan Manuel Martos-Martínez; Oscar Vidal-Pérez; Patricia Luengo-Pierrard; Jesús María Villar-Del-Moral Journal: Contemp Clin Trials Commun Date: 2021-06-15