R Nakov1, T Velikova, V Nakov, G Ianiro, V Gerova, L Tankova. 1. Clinic of Gastroenterology, "Tsaritsa Yoanna - ISUL" University Hospital, Medical University of Sofia, Sofia, Bulgaria. radislav.nakov@gmail.com.
Abstract
OBJECTIVE: In this study, we aimed to evaluate the role of serum trefoil factor 3 (TFF3) as a biomarker of disease activity in patients with inflammatory bowel disease (IBD) and to compare TFF3 values with those of fecal calprotectin (FC). PATIENTS AND METHODS: 128 patients with IBD were divided into four groups: 1) active ulcerative colitis (UC); 2) quiescent UC; 3) active Crohn's disease (CD); 4) quiescent CD. The serum levels of TFF3 and FC levels were assessed in all patients and 16 controls. RESULTS: Patients with active UC had higher TFF3 levels than those with quiescent UC (p<0.001), those with active (p<0.001) or quiescent CD (p<0.001) and controls (p <0.001). We found a correlation between TFF3 and FC values in patients with active (r = 0.478, p = 0.006) and quiescent UC (r=0.528, p=0.002). TFF3 levels correlated with endoscopic activity in UC (evaluated by UC Endoscopic Index of Severity - UCEIS) (r=0.662, p<0.001). CONCLUSIONS: Serum TFF3 is able to identify patients with active UC. It could be used as a marker to predict disease activity in patients with UC.
OBJECTIVE: In this study, we aimed to evaluate the role of serum trefoil factor 3 (TFF3) as a biomarker of disease activity in patients with inflammatory bowel disease (IBD) and to compare TFF3 values with those of fecal calprotectin (FC). PATIENTS AND METHODS: 128 patients with IBD were divided into four groups: 1) active ulcerative colitis (UC); 2) quiescent UC; 3) active Crohn's disease (CD); 4) quiescent CD. The serum levels of TFF3 and FC levels were assessed in all patients and 16 controls. RESULTS:Patients with active UC had higher TFF3 levels than those with quiescent UC (p<0.001), those with active (p<0.001) or quiescent CD (p<0.001) and controls (p <0.001). We found a correlation between TFF3 and FC values in patients with active (r = 0.478, p = 0.006) and quiescent UC (r=0.528, p=0.002). TFF3 levels correlated with endoscopic activity in UC (evaluated by UC Endoscopic Index of Severity - UCEIS) (r=0.662, p<0.001). CONCLUSIONS: Serum TFF3 is able to identify patients with active UC. It could be used as a marker to predict disease activity in patients with UC.
Authors: Jonathan W J Lee; Feng Zhu; Supriya Srivastava; Stephen Kk Tsao; Christopher Khor; Khek Yu Ho; Kwong Ming Fock; Wee Chian Lim; Tiing Leong Ang; Wan Cheng Chow; Jimmy Bok Yan So; Calvin J Koh; Shijia Joy Chua; Andrew S Y Wong; Jaideepraj Rao; Lee Guan Lim; Khoon Lin Ling; Chung-King Chia; Choon Jin Ooi; Andrea Rajnakova; Wai Ming Yap; Manuel Salto-Tellez; Bow Ho; Richie Soong; Kee Seng Chia; Yik Ying Teo; Ming Teh; Khay-Guan Yeoh Journal: Gut Date: 2021-05-11 Impact factor: 23.059