So Mi Lee1, Soonhak Kwon2, Yun Jeong Lee3. 1. Department of Radiology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea. 2. Department of Pediatric, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea. 3. Department of Pediatric, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea. Electronic address: oilily1103@hanmail.net.
Abstract
PURPOSE: Arterial spine labeling (ASL) magnetic resonance imaging (MRI) is the non-invasive measurement of cerebral blood flow that can localize the seizure focus in patients with epilepsy. The aim of this study was to identify its utility for localizing the seizure focus in children with no structural lesion on MRI. METHODS: Forty-three consecutive children who underwent electroencephalography (EEG) and structural MRI, along with ASL for evaluation of newly developed seizures, were included. ASL abnormalities were classified as hypo/hyperperfusion, based on visual assessment, and compared with the seizure focus determined by clinical information and EEG. RESULTS: Among the 43 patients (M 17: F 26, mean age, 6.3 ± 3.3 years), the seizure type was focal in 36 patients and generalized in seven patients. Twenty-five (58.1%) patients showed perfusion change. Out of 36 patients with focal seizure, 24 (66.7%) showed ASL abnormalities, and 19 (52.8%) showed concordance between ASL and clinical focus. Out of seven patients with generalized seizure, only one patient showed ASL abnormalities. The overall concordance revealed moderate agreement (k = 0.542). ASL acquisition within one day from seizure onset was the only significant associating factor with the concordance between the two (p = 0. 014). CONCLUSION: To our knowledge, this is the first study to assess the usefulness of ASL MRI to assist in localizing the seizure focus in MR-negative children with new onset seizures. The combined use of ASL with EEG and structural MRI may play an important role in the evaluation of pediatric epilepsy.
PURPOSE: Arterial spine labeling (ASL) magnetic resonance imaging (MRI) is the non-invasive measurement of cerebral blood flow that can localize the seizure focus in patients with epilepsy. The aim of this study was to identify its utility for localizing the seizure focus in children with no structural lesion on MRI. METHODS: Forty-three consecutive children who underwent electroencephalography (EEG) and structural MRI, along with ASL for evaluation of newly developed seizures, were included. ASL abnormalities were classified as hypo/hyperperfusion, based on visual assessment, and compared with the seizure focus determined by clinical information and EEG. RESULTS: Among the 43 patients (M 17: F 26, mean age, 6.3 ± 3.3 years), the seizure type was focal in 36 patients and generalized in seven patients. Twenty-five (58.1%) patients showed perfusion change. Out of 36 patients with focal seizure, 24 (66.7%) showed ASL abnormalities, and 19 (52.8%) showed concordance between ASL and clinical focus. Out of seven patients with generalized seizure, only one patient showed ASL abnormalities. The overall concordance revealed moderate agreement (k = 0.542). ASL acquisition within one day from seizure onset was the only significant associating factor with the concordance between the two (p = 0. 014). CONCLUSION: To our knowledge, this is the first study to assess the usefulness of ASL MRI to assist in localizing the seizure focus in MR-negative children with new onset seizures. The combined use of ASL with EEG and structural MRI may play an important role in the evaluation of pediatric epilepsy.
Authors: Martin Kojan; Martin Gajdoš; Pavel Říha; Irena Doležalová; Zdeněk Řehák; Ivan Rektor Journal: Brain Topogr Date: 2021-03-30 Impact factor: 3.020
Authors: Radek Mareček; Pavel Říha; Michaela Bartoňová; Martin Kojan; Martin Lamoš; Martin Gajdoš; Lubomír Vojtíšek; Michal Mikl; Marek Bartoň; Irena Doležalová; Martin Pail; Ondřej Strýček; Marta Pažourková; Milan Brázdil; Ivan Rektor Journal: Hum Brain Mapp Date: 2021-03-27 Impact factor: 5.038
Authors: Pavel Říha; Irena Doležalová; Radek Mareček; Martin Lamoš; Michaela Bartoňová; Martin Kojan; Michal Mikl; Martin Gajdoš; Lubomír Vojtíšek; Marek Bartoň; Ondřej Strýček; Martin Pail; Milan Brázdil; Ivan Rektor Journal: Sci Rep Date: 2022-09-07 Impact factor: 4.996