| Literature DB >> 30716541 |
Tenielle Porter1, Samantha C Burnham2, Lidija Milicic1, Greg Savage3, Paul Maruff4, Yen Ying Lim5, David Ames6, Colin L Masters5, Ralph N Martins7, Stephanie Rainey-Smith7, Christopher C Rowe8, Olivier Salvado9, David Groth10, Giuseppe Verdile11, Victor L Villemagne12, Simon M Laws13.
Abstract
The longevity gene Klotho (KL), specifically the functional KL-VS variant, has previously been associated with cognition and rates of cognitive decline. This study aimed to determine whether KL-VS associations with cognition were observable in preclinical Alzheimer's disease (AD). The study also aimed to determine whether there was a combined influence of KL-VS, neocortical amyloid-β (Aβ) burden, and carriage of the apolipoprotein E (APOE) ε4 allele on cognitive decline. This study involved 581 Aβ-imaged, cognitively normal older adults, enrolled in the Australian Imaging, Biomarkers and Lifestyle Study of Aging. Linear mixed effects models revealed no significant associations between KL-VS and cognitive decline independently or in combination with Aβ burden and APOE ε4 genotype. Overall, previous associations reported between KL-VS and cognitive decline are not observed at the preclinical stages of AD. Furthermore, the results do not support the hypothesis that KL-VS has a modifying effect on Aβ burden and APOE ε4-driven cognitive decline in preclinical AD.Entities:
Keywords: Alzheimer's disease; Cognition; Episodic memory; KL-VS; Klotho; Preclinical; amyloid-β
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Year: 2019 PMID： 30716541 DOI： 10.1016/j.neurobiolaging.2018.12.014
Source DB: PubMed Journal: Neurobiol Aging ISSN： 0197-4580 Impact factor: 4.673