Literature DB >> 30715103

Detection of Nicotine and Nicotine Metabolites in Units of Banked Blood.

Joesph R Wiencek1, Eric A Gehrie2, Amaris M Keiser3, Penny C Szklarski4, Kamisha L Johnson-Davis5,6, Garrett S Booth4.   

Abstract

OBJECTIVES: To determine the concentrations of nicotine and nicotine metabolites in RBC units as a means to estimate the point prevalence of exposure within the healthy donor pool.
METHODS: Segments from 105 RBC units were tested for the presence of nicotine, cotinine, or trans-3'-hydroxycotinine by liquid chromatography-tandem mass spectrometry.
RESULTS: Of the 20 (19%) units that contained detectable concentrations of nicotine, cotinine, or trans-3'-hydroxycotinine, 19 (18.1%) contained concentrations consistent with the use of a nicotine-containing product within 48 hours of specimen collection. One RBC unit contained nicotine concentrations consistent with passive exposure.
CONCLUSIONS: Chemicals from nicotine-containing products are detectable within the US RBC supply. Further investigation is needed to determine the risks of transfusion-associated exposure to nicotine and other tobacco-associated chemicals among vulnerable patient populations such as neonates. © American Society for Clinical Pathology, 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Year:  2019        PMID： 30715103      PMCID： PMC7179511          DOI： 10.1093/ajcp/aqy176

Source DB:  PubMed          Journal:  Am J Clin Pathol        ISSN： 0002-9173            Impact factor:   2.493


  24 in total

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2.  Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects.

Authors:  Aiguo Ren; Xinghua Qiu; Lei Jin; Jin Ma; Zhiwen Li; Le Zhang; Huiping Zhu; Richard H Finnell; Tong Zhu
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Review 3.  Red blood cell transfusion: a clinical practice guideline from the AABB*.

Authors:  Jeffrey L Carson; Brenda J Grossman; Steven Kleinman; Alan T Tinmouth; Marisa B Marques; Mark K Fung; John B Holcomb; Orieji Illoh; Lewis J Kaplan; Louis M Katz; Sunil V Rao; John D Roback; Aryeh Shander; Aaron A R Tobian; Robert Weinstein; Lisa Grace Swinton McLaughlin; Benjamin Djulbegovic
Journal:  Ann Intern Med       Date:  2012-07-03       Impact factor: 25.391

4.  Primary prevention of pediatric lead exposure requires new approaches to transfusion screening.

Authors:  Eric Gehrie; Amaris Keiser; Sheila Dawling; James Travis; Frederick G Strathmann; Garrett S Booth
Journal:  J Pediatr       Date:  2013-04-10       Impact factor: 4.406

5.  Carbon monoxide concentration in donated blood: relation to cigarette smoking and other sources.

Authors:  Anna-Maja Aberg; Birgitta Nilsson Sojka; Ola Winsö; Pernilla Abrahamsson; Göran Johansson; Jan Erik Larsson
Journal:  Transfusion       Date:  2008-10-28       Impact factor: 3.157

6.  Simultaneous analysis of nicotine, nicotine metabolites, and tobacco alkaloids in serum or urine by tandem mass spectrometry, with clinically relevant metabolic profiles.

Authors:  Thomas P Moyer; Joel R Charlson; Robert J Enger; Lowell C Dale; Jon O Ebbert; Darrell R Schroeder; Richard D Hurt
Journal:  Clin Chem       Date:  2002-09       Impact factor: 8.327

7.  Maternal occupational exposure to polycyclic aromatic hydrocarbons: effects on gastroschisis among offspring in the National Birth Defects Prevention Study.

Authors:  Philip J Lupo; Peter H Langlois; Jennita Reefhuis; Christina C Lawson; Elaine Symanski; Tania A Desrosiers; Zeina G Khodr; A J Agopian; Martha A Waters; Kara N Duwe; Richard H Finnell; Laura E Mitchell; Cynthia A Moore; Paul A Romitti; Gary M Shaw
Journal:  Environ Health Perspect       Date:  2012-02-13       Impact factor: 9.031

Review 8.  Overview of Cotinine Cutoff Values for Smoking Status Classification.

Authors:  Sungroul Kim
Journal:  Int J Environ Res Public Health       Date:  2016-12-14       Impact factor: 3.390

9.  Validation of a LC-MS/MS method for quantifying urinary nicotine, six nicotine metabolites and the minor tobacco alkaloids--anatabine and anabasine--in smokers' urine.

Authors:  James E McGuffey; Binnian Wei; John T Bernert; John C Morrow; Baoyun Xia; Lanqing Wang; Benjamin C Blount
Journal:  PLoS One       Date:  2014-07-11       Impact factor: 3.240

10.  Current Cigarette Smoking Among Adults - United States, 2016.

Authors:  Ahmed Jamal; Elyse Phillips; Andrea S Gentzke; David M Homa; Stephen D Babb; Brian A King; Linda J Neff
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2018-01-19       Impact factor: 17.586
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  2 in total

1.  Association of donor age, body mass index, hemoglobin, and smoking status with in-hospital mortality and length of stay among red blood cell-transfused recipients.

Authors:  Nareg H Roubinian; Matt Westlake; Elizabeth M St Lezin; Gustaf Edgren; Don J Brambilla; Catherine Lee; Roberta Bruhn; Ritchard G Cable; Darrell J Triulzi; Simone A Glynn; Steve Kleinman; Edward L Murphy
Journal:  Transfusion       Date:  2019-10-11       Impact factor: 3.157

2.  Additive effects of blood donor smoking and gamma irradiation on outcome measures of red blood cell transfusion.

Authors:  Robert A DeSimone; Colleen Plimier; Catherine Lee; Tamir Kanias; Melissa M Cushing; Bruce S Sachais; Steven Kleinman; Michael P Busch; Nareg H Roubinian
Journal:  Transfusion       Date:  2020-05-01       Impact factor: 3.337
  2 in total

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