| Literature DB >> 30714736 |
Yanrong Shi1, Juanli Zhang2, Xiuyu Tian1, Xingkang Wu1,3, Tianhong Li1, Chunhua Lu1, Yuemao Shen1,4.
Abstract
This study reported the isolation and characterization of 11 rifamycin congeners including six new ones (1-6) from the agar fermentation extract of Amycolatopsis mediterranei S699. Compounds 1 and 2 are rifamycin glycosides named as rifamycinosides A and B, respectively. Their polyketide skeleton represents a novel cleavage pattern of the rifamycin ansa chain. Compounds 6 and 8 showed potential T3SS inhibitory activity, and 6 induced G2/M phase arrest and caused DNA damage in HCT116 cells.Entities:
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Year: 2019 PMID： 30714736 DOI： 10.1021/acs.orglett.8b03792
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005