Keng-Chung Shen1, Yi-Tsen Lin1,2, Chih-Feng Lin1, Chin-Hao Chang3, Te-Huei Yeh1. 1. a Department of Otolaryngology , College of Medicine, National Taiwan University Hospital , Taipei , Taiwan. 2. b Graduate School of Clinical Medicine, National Taiwan University College of Medicine , Taipei , Taiwan. 3. c Department of Medical Research , National Taiwan University Hospital , Taipei , Taiwan.
Abstract
BACKGROUND: The role of allergy in the development of chronic rhinosinusitis (CRS) in East Asians is not clear. AIMS/ OBJECTIVES: The aim was to investigate the impact of allergies in the clinical characteristics of chronic rhinosinusitis. MATERIAL AND METHODS: A total of 138 CRS patients who underwent endoscopic sinus surgery were included. A brief history of rhinosinusitis symptoms, blood eosinophil count, blood-specific allergen tests, computed tomography (CT) scan findings, Lund-Mackay (LM) CT scores, and Sino-Nasal Outcome Test (SNOT-22) Questionnaire scores, and sinoscopy findings at 3 and 6 months postoperatively. RESULTS: The ImmunoCAP test was positive in 71(51%) patients and negative in 67(49%) patients. The mean age of those who received endoscopic sinus surgery was 7-years younger in the allergic group compared with the non-allergic group (p = .008). The peripheral eosinophil count in the allergic group was higher than that of the non-allergic group (p = .008). The LM scores and SNOT-22 scores were not significantly different between the two groups. The recurrence rate of nasal polyps in the allergic group was higher but without statistical significance. CONCLUSIONS AND SIGNIFICANCE: Allergy may accelerate the disease progression of CRS. The presence of the serum-specific IgE was correlated with peripheral eosinophil percentage, especially in the CRSwNP patients.
BACKGROUND: The role of allergy in the development of chronic rhinosinusitis (CRS) in East Asians is not clear. AIMS/ OBJECTIVES: The aim was to investigate the impact of allergies in the clinical characteristics of chronic rhinosinusitis. MATERIAL AND METHODS: A total of 138 CRSpatients who underwent endoscopic sinus surgery were included. A brief history of rhinosinusitis symptoms, blood eosinophil count, blood-specific allergen tests, computed tomography (CT) scan findings, Lund-Mackay (LM) CT scores, and Sino-Nasal Outcome Test (SNOT-22) Questionnaire scores, and sinoscopy findings at 3 and 6 months postoperatively. RESULTS: The ImmunoCAP test was positive in 71(51%) patients and negative in 67(49%) patients. The mean age of those who received endoscopic sinus surgery was 7-years younger in the allergic group compared with the non-allergic group (p = .008). The peripheral eosinophil count in the allergic group was higher than that of the non-allergic group (p = .008). The LM scores and SNOT-22 scores were not significantly different between the two groups. The recurrence rate of nasal polyps in the allergic group was higher but without statistical significance. CONCLUSIONS AND SIGNIFICANCE: Allergy may accelerate the disease progression of CRS. The presence of the serum-specific IgE was correlated with peripheral eosinophil percentage, especially in the CRSwNP patients.