Sneha Mantri1,2, Chinwe Nwadiogbu1, Whitney Fitts3, Nabila Dahodwala1. 1. Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. 2. Department of Neurology, Duke University School of Medicine, Durham, North Carolina. 3. Harvard Medical School, Boston, Massachusetts.
Abstract
OBJECTIVES: Screening tests of global cognition detect racial differences in scores even after adjustment for educational attainment. Differential educational environments in adolescence may affect individual cognitive function. This study examines the impact of high school educational quality on late-life cognition among community-dwelling older adults. METHODS/ DESIGN: Data were collected from community-dwelling individuals from the Philadelphia Healthy Brain Aging (PHBA) cohort at the University of Pennsylvania Health System. The present analysis included subjects from the PHBA over the age of 55 years without a diagnosis of Parkinson's disease or dementia, who had attended high school in the City of Philadelphia. Cognition was assessed using the Montreal Cognitive Assessment (MoCA); clinical information was abstracted from the subject's electronic health record. High school information was obtained from the Philadelphia Board of Education. After univariable correlations were defined, we performed stepwise multiple linear regression models to determine the most significant predictors of late-life cognitive status. RESULTS: A total of 130 subjects meeting inclusion criteria were included in the analysis. Years of education, race, educational level, school district, and financial status were all positively associated with MoCA. Significant negative associations included composite vascular risk, attendance at highly segregated schools, and historical poverty status. In stepwise multiple linear regression modeling, the impact of race on cognition remained significant when educational attainment was added to the model but was no longer significant once segregation status was added. CONCLUSIONS: This work suggests that academic and community factors beyond years of education have a marked impact on late-life cognition.
OBJECTIVES: Screening tests of global cognition detect racial differences in scores even after adjustment for educational attainment. Differential educational environments in adolescence may affect individual cognitive function. This study examines the impact of high school educational quality on late-life cognition among community-dwelling older adults. METHODS/ DESIGN: Data were collected from community-dwelling individuals from the Philadelphia Healthy Brain Aging (PHBA) cohort at the University of Pennsylvania Health System. The present analysis included subjects from the PHBA over the age of 55 years without a diagnosis of Parkinson's disease or dementia, who had attended high school in the City of Philadelphia. Cognition was assessed using the Montreal Cognitive Assessment (MoCA); clinical information was abstracted from the subject's electronic health record. High school information was obtained from the Philadelphia Board of Education. After univariable correlations were defined, we performed stepwise multiple linear regression models to determine the most significant predictors of late-life cognitive status. RESULTS: A total of 130 subjects meeting inclusion criteria were included in the analysis. Years of education, race, educational level, school district, and financial status were all positively associated with MoCA. Significant negative associations included composite vascular risk, attendance at highly segregated schools, and historical poverty status. In stepwise multiple linear regression modeling, the impact of race on cognition remained significant when educational attainment was added to the model but was no longer significant once segregation status was added. CONCLUSIONS: This work suggests that academic and community factors beyond years of education have a marked impact on late-life cognition.
Authors: Rachel L Peterson; Kristen M George; Lisa L Barnes; Paola Gilsanz; Elizabeth Rose Mayeda; M Maria Glymour; Dan M Mungas; Rachel A Whitmer Journal: JAMA Netw Open Date: 2021-10-01
Authors: Görkem Anapa; Mandy Roheger; Ümran Sema Seven; Hannah Liebermann-Jordanidis; Oezguer A Onur; Josef Kessler; Elke Kalbe Journal: Int J Environ Res Public Health Date: 2021-06-11 Impact factor: 3.390