Ali Amad1, Nicolas Ramoz2, Hugo Peyre3, Pierre Thomas4, Philip Gorwood5. 1. Univ. Lille, CNRS UMR 9193-PsyCHIC-SCALab, & CHU Lille, Pôle de Psychiatrie, Unité CURE, Lille F-59000, France; INSERM UMRS1266, Institute of Psychiatry and Neuroscience of Paris, France. Electronic address: ali.amad@chru-lille.fr. 2. INSERM UMRS1266, Institute of Psychiatry and Neuroscience of Paris, France. 3. Assistance Publique-Hôpitaux de Paris, Robert Debré Hospital, Child and Adolescent Psychiatry Department, INSERM UMR 1141, Paris Diderot University, Paris, France. 4. Univ. Lille, CNRS UMR 9193-PsyCHIC-SCALab, & CHU Lille, Pôle de Psychiatrie, Unité CURE, Lille F-59000, France. 5. INSERM UMRS1266, Institute of Psychiatry and Neuroscience of Paris, France; Sainte-Anne hospital (Paris-Descartes university), Paris, France.
Abstract
BACKGROUND: Genes associated with the physiological response to stress in the hypothalamic-pituitary-adrenal axis are considered as good candidates for genetic research in borderline personality disorder (BPD). METHODS: In this study, five FKBP5 (a co-chaperone of the glucocorticoid receptor) SNPs (rs3800373, rs9296158, rs737054, rs1360780, rs9470080) were genotyped in a sample of 101 unrelated Caucasian patients with BPD and 111 ethnically matched healthy controls. The interaction between FKBP5 polymorphisms and childhood trauma was also tested. RESULTS: All FKBP5 polymorphisms genotyped showed significant associations with BPD. A main effect of rs9470080 (p = 0.01) and gene x environment (physical abuse) interaction (p = 0.01) was found. A gene x environment (emotional abuse) interaction was also found for rs3800373 (p = 0.03). However, these interactions did not remain significant after multiple testing corrections. LIMITATIONS: In this study, only 5 genetic variants were tested and thus tagging of the FKBP5 gene was incomplete. Moreover, the sample size is moderate. CONCLUSION: BPD is associated with FKBP5 polymorphisms and several types of childhood abuse may modulate the effect between FKBP5 SNPs and this disorder.
BACKGROUND: Genes associated with the physiological response to stress in the hypothalamic-pituitary-adrenal axis are considered as good candidates for genetic research in borderline personality disorder (BPD). METHODS: In this study, five FKBP5 (a co-chaperone of the glucocorticoid receptor) SNPs (rs3800373, rs9296158, rs737054, rs1360780, rs9470080) were genotyped in a sample of 101 unrelated Caucasian patients with BPD and 111 ethnically matched healthy controls. The interaction between FKBP5 polymorphisms and childhood trauma was also tested. RESULTS: All FKBP5 polymorphisms genotyped showed significant associations with BPD. A main effect of rs9470080 (p = 0.01) and gene x environment (physical abuse) interaction (p = 0.01) was found. A gene x environment (emotional abuse) interaction was also found for rs3800373 (p = 0.03). However, these interactions did not remain significant after multiple testing corrections. LIMITATIONS: In this study, only 5 genetic variants were tested and thus tagging of the FKBP5 gene was incomplete. Moreover, the sample size is moderate. CONCLUSION: BPD is associated with FKBP5 polymorphisms and several types of childhood abuse may modulate the effect between FKBP5 SNPs and this disorder.
Authors: Filip Stramecki; Dorota Frydecka; Łukasz Gawęda; Katarzyna Prochwicz; Joanna Kłosowska; Jerzy Samochowiec; Krzysztof Szczygieł; Edyta Pawlak; Elżbieta Szmida; Paweł Skiba; Andrzej Cechnicki; Błażej Misiak Journal: Brain Sci Date: 2021-04-28
Authors: María J Arranz; Cristina Gallego-Fabrega; Ana Martín-Blanco; Joaquim Soler; Matilde Elices; Elisabet Dominguez-Clavé; Juliana Salazar; Daniel Vega; Laia Briones-Buixassa; Juan Carlos Pascual Journal: Transl Psychiatry Date: 2021-01-05 Impact factor: 6.222