Literature DB >> 30711482

Intravascular Mesenchymal Stromal/Stem Cell Therapy Product Diversification: Time for New Clinical Guidelines.

Guido Moll1, James A Ankrum2, Julian Kamhieh-Milz3, Karen Bieback4, Olle Ringdén5, Hans-Dieter Volk6, Sven Geissler7, Petra Reinke8.   

Abstract

Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has demonstrated that bone marrow MSC infusion is safe. It is not clear if this also applies to diverse new cell products derived from other sources, such as adipose and perinatal tissues. Different MSC products display varying levels of highly procoagulant tissue factor (TF) and may adversely trigger the instant blood-mediated inflammatory reaction (IBMIR). Suitable strategies for assessing and controlling hemocompatibility and optimized cell delivery are crucial for the development of safer and more effective MSC therapies.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  CD142; cellular therapy; hemocompatibility; mesenchymal stromal/stem cell; safety and efficacy; tissue factor; tissue source

Mesh：

Substances：

Year:  2019        PMID： 30711482     DOI： 10.1016/j.molmed.2018.12.006

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  117 in total

1.  Therapeutic implications of transplanted-cell death.

Authors:  Zachary W Wagoner; Weian Zhao
Journal:  Nat Biomed Eng       Date:  2021-05       Impact factor: 25.671

2.  Post-stroke Impairment of the Blood-Brain Barrier and Perifocal Vasogenic Edema Is Alleviated by Endovascular Mesenchymal Stem Cell Administration: Modulation of the PKCδ/MMP9/AQP4-Mediated Pathway.

Authors:  Aishika Datta; Deepaneeta Sarmah; Harpreet Kaur; Antra Chaudhary; Kamisetty Leela Mounica; Kiran Kalia; Anupom Borah; Dileep R Yavagal; Pallab Bhattacharya
Journal:  Mol Neurobiol       Date:  2022-02-21       Impact factor: 5.590

3.  Mechanism of Action of Mesenchymal Stem Cells (MSCs): impact of delivery method.

Authors:  Luiza L Bagno; Alessandro G Salerno; Wayne Balkan; Joshua M Hare
Journal:  Expert Opin Biol Ther       Date:  2021-12-27       Impact factor: 4.388

Review 4.  Engineering the MSC Secretome: A Hydrogel Focused Approach.

Authors:  Marissa E Wechsler; Varsha V Rao; Alexandra N Borelli; Kristi S Anseth
Journal:  Adv Healthc Mater       Date:  2021-02-17       Impact factor: 9.933

Review 5.  Extracellular Vesicles for the Treatment of Radiation Injuries.

Authors:  Lalitha Sarad Yamini Nanduri; Phaneendra K Duddempudi; Weng-Lang Yang; Radia Tamarat; Chandan Guha
Journal:  Front Pharmacol       Date:  2021-05-18       Impact factor: 5.988

6.  The whole profiling and competing endogenous RNA network analyses of noncoding RNAs in adipose-derived stem cells from diabetic, old, and young patients.

Authors:  Sen Ren; Hewei Xiong; Jing Chen; Xiaofan Yang; Yutian Liu; Jiahe Guo; Tao Jiang; Zhao Xu; Meng Yuan; Yang Liu; Nan Zhou; Hongrui Chen; Wenqing Li; Hans-Günther Machens; Zhenbing Chen
Journal:  Stem Cell Res Ther       Date:  2021-05-29       Impact factor: 6.832

7.  Potential Networks Regulated by MSCs in Acute-On-Chronic Liver Failure: Exosomal miRNAs and Intracellular Target Genes.

Authors:  Jing Zhang; Juan Gao; Dengna Lin; Jing Xiong; Jialei Wang; Junfeng Chen; Bingliang Lin; Zhiliang Gao
Journal:  Front Genet       Date:  2021-04-23       Impact factor: 4.599

8.  Short lifespan of syngeneic transplanted MSC is a consequence of in vivo apoptosis and immune cell recruitment in mice.

Authors:  Mihai Bogdan Preda; Carmen Alexandra Neculachi; Ioana Madalina Fenyo; Ana-Maria Vacaru; Mihai Alin Publik; Maya Simionescu; Alexandrina Burlacu
Journal:  Cell Death Dis       Date:  2021-06-02       Impact factor: 8.469

Review 9.  Are We Ready for Cell Therapy to Treat Stroke?

Authors:  Fernando José Rascón-Ramírez; Noelia Esteban-García; Juan Antonio Barcia; Albert Trondin; Cristina Nombela; Leyre Sánchez-Sánchez-Rojas
Journal:  Front Cell Dev Biol       Date:  2021-06-23

Review 10.  Dissecting the Role of Mesenchymal Stem Cells in Idiopathic Pulmonary Fibrosis: Cause or Solution.

Authors:  Anna Valeria Samarelli; Roberto Tonelli; Irene Heijink; Aina Martin Medina; Alessandro Marchioni; Giulia Bruzzi; Ivana Castaniere; Dario Andrisani; Filippo Gozzi; Linda Manicardi; Antonio Moretti; Stefania Cerri; Riccardo Fantini; Luca Tabbì; Chiara Nani; Ilenia Mastrolia; Daniel J Weiss; Massimo Dominici; Enrico Clini
Journal:  Front Pharmacol       Date:  2021-07-05       Impact factor: 5.810
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.