Yeong-Min Lim1, Pil-Sung Yang2, Eunsun Jang3, Hee Tae Yu3, Tae-Hoon Kim3, Jae-Sun Uhm3, Jong-Youn Kim3, Hui-Nam Pak3, Moon-Hyoung Lee3, Boyoung Joung4, Gregory Y H Lip5. 1. Division of Cardiology, Department of Internal Medicine, Yonsei University Health System, Seoul, Korea; Department of Cardiology, Anyang SAM Medical Center, Korea. 2. Department of Cardiology, CHA Bundang Medical Center, CHA University, Seongnam, Korea. 3. Division of Cardiology, Department of Internal Medicine, Yonsei University Health System, Seoul, Korea. 4. Division of Cardiology, Department of Internal Medicine, Yonsei University Health System, Seoul, Korea. Electronic address: cby6908@yuhs.ac. 5. Division of Cardiology, Department of Internal Medicine, Yonsei University Health System, Seoul, Korea; Institute of Cardiovascular Sciences, University of Birmingham, United Kingdom; Liverpool Centre for Cardiovascular Science, University of Liverpool, United Kingdom. Electronic address: g.y.h.lip@bham.ac.uk.
Abstract
OBJECTIVE: To assess the effects of body mass index (BMI) variability on the incidence of new-onset atrial fibrillation (AF), stroke, cardiovascular (CV) risk factors, and CV outcomes in a general Asian population. PATIENTS AND METHODS: Data from the National Health Insurance Service-Health Screening cohort in Korea were used: 171,324 patients without AF were included, and BMI measurements occurred biennially from January 1, 2002, through December 31, 2009. Patient outcomes were followed through 2013. The BMI intraindividual variability between visits was measured. RESULTS: During mean ± SD follow-up of 47.4±3.9 months, 1959 patients (1.1%) developed new-onset AF. Overweight or obesity (BMI ≥25) had a greater risk of new-onset AF compared with BMI of 20 to 22.5, with a hazard ratio (HR) of 1.24 (95% CI, 1.10-1.41; P<.001). In underweight or normal-weight participants (initial BMI <25), a 1-kg/m2 increase of BMI variability increased the risk of new-onset AF, with an adjusted HR (aHR) of 1.13 (95% CI, 1.01-1.25; P=.02). Weight gain increased the risk of new-onset AF (aHR, 1.32; 95% CI, 1.01-1.71; P=.04) and myocardial infarction (aHR, 1.52; 95% CI, 1.06-2.18; P=.02) but not stroke. In this group, blood pressure, glucose level, and total cholesterol level were higher in individuals with the greatest BMI variability compared with those with stable BMI. CONCLUSION: In the underweight and normal-weight Asian population, BMI variability, especially weight gain, was related to increased risk of new-onset AF and myocardial infarction. Avoiding weight gain is important to improve CV outcomes.
OBJECTIVE: To assess the effects of body mass index (BMI) variability on the incidence of new-onset atrial fibrillation (AF), stroke, cardiovascular (CV) risk factors, and CV outcomes in a general Asian population. PATIENTS AND METHODS: Data from the National Health Insurance Service-Health Screening cohort in Korea were used: 171,324 patients without AF were included, and BMI measurements occurred biennially from January 1, 2002, through December 31, 2009. Patient outcomes were followed through 2013. The BMI intraindividual variability between visits was measured. RESULTS: During mean ± SD follow-up of 47.4±3.9 months, 1959 patients (1.1%) developed new-onset AF. Overweight or obesity (BMI ≥25) had a greater risk of new-onset AF compared with BMI of 20 to 22.5, with a hazard ratio (HR) of 1.24 (95% CI, 1.10-1.41; P<.001). In underweight or normal-weight participants (initial BMI <25), a 1-kg/m2 increase of BMI variability increased the risk of new-onset AF, with an adjusted HR (aHR) of 1.13 (95% CI, 1.01-1.25; P=.02). Weight gain increased the risk of new-onset AF (aHR, 1.32; 95% CI, 1.01-1.71; P=.04) and myocardial infarction (aHR, 1.52; 95% CI, 1.06-2.18; P=.02) but not stroke. In this group, blood pressure, glucose level, and total cholesterol level were higher in individuals with the greatest BMI variability compared with those with stable BMI. CONCLUSION: In the underweight and normal-weight Asian population, BMI variability, especially weight gain, was related to increased risk of new-onset AF and myocardial infarction. Avoiding weight gain is important to improve CV outcomes.
Authors: Sung Hoon Kang; Jong Hyuk Kim; Yoosoo Chang; Bo Kyoung Cheon; Yeong Sim Choe; Hyemin Jang; Hee Jin Kim; Seong-Beom Koh; Duk L Na; Kyunga Kim; Sang Won Seo Journal: Front Aging Neurosci Date: 2022-07-22 Impact factor: 5.702