Haibin Li1, Dian He1, Deqiang Zheng1, Endawoke Amsalu1, Anxin Wang2, Lixin Tao1, Jin Guo3, Xia Li4, Wei Wang5, Xiuhua Guo6. 1. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China; Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China. 2. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. 3. Guanghua Group Pty Ltd, Melbourne, Victoria, Australia. 4. Department of Mathematics and Statistics, La Trobe University, Melbourne, Victoria, Australia. 5. Global Health and Genomics, School of Medical Sciences and Health, Edith Cowan University, Perth, Western Australia, Australia. 6. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China; Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China. Electronic address: statguo@ccmu.edu.cn.
Abstract
BACKGROUND: Epidemiologic evidence on metabolically healthy obese (MHO) phenotype and cardiovascular diseases (CVD) risk remains controversial. AIMS: We aim to examine the relationship between MHO and risk of CVD among the Chinese population. METHODS: The China Health and Retirement Longitudinal Study is a prospective cohort study of 7849 participants aged ≥45 years without CVD at baseline. Metabolic health status was assessed based on blood pressure, triglycerides, high-density lipoprotein cholesterol, glycated hemoglobin, fasting glucose, and C-reactive protein. A cutoff point of body mass index of 24.0 kg/m2 was used to define over-weight/obesity (≥24.0 kg/m2) or normal weight (<24.0 kg/m2). CVD was based on self-reported doctor's diagnosis of heart problems and stroke. Incidence rate ratio (IRR) with 95% confidence interval (CI) was deduced from modified Poisson regression. RESULTS: During a mean 3.6 years of follow-up, 880 incident CVD events were recorded. 789 (10.05%) were identified MHO among 3321 (42.3%) obese individuals. Compared with metabolically healthy normal weight individuals, the multivariable adjusted IRR of CVD was 1.33 (95%CI: 1.19-1.49) for MHO, 1.29 (95%CI: 1.22-1.38) for metabolically unhealthy normal weight, and 1.61 (95%CI: 1.51-1.75) for metabolically unhealthy obese in the full adjusted model. CONCLUSIONS: MHO individuals are associated with the increased risk of cardiovascular diseases among the Chinese population.
BACKGROUND: Epidemiologic evidence on metabolically healthy obese (MHO) phenotype and cardiovascular diseases (CVD) risk remains controversial. AIMS: We aim to examine the relationship between MHO and risk of CVD among the Chinese population. METHODS: The China Health and Retirement Longitudinal Study is a prospective cohort study of 7849 participants aged ≥45 years without CVD at baseline. Metabolic health status was assessed based on blood pressure, triglycerides, high-density lipoprotein cholesterol, glycated hemoglobin, fasting glucose, and C-reactive protein. A cutoff point of body mass index of 24.0 kg/m2 was used to define over-weight/obesity (≥24.0 kg/m2) or normal weight (<24.0 kg/m2). CVD was based on self-reported doctor's diagnosis of heart problems and stroke. Incidence rate ratio (IRR) with 95% confidence interval (CI) was deduced from modified Poisson regression. RESULTS: During a mean 3.6 years of follow-up, 880 incident CVD events were recorded. 789 (10.05%) were identified MHO among 3321 (42.3%) obese individuals. Compared with metabolically healthy normal weight individuals, the multivariable adjusted IRR of CVD was 1.33 (95%CI: 1.19-1.49) for MHO, 1.29 (95%CI: 1.22-1.38) for metabolically unhealthy normal weight, and 1.61 (95%CI: 1.51-1.75) for metabolically unhealthy obese in the full adjusted model. CONCLUSIONS: MHO individuals are associated with the increased risk of cardiovascular diseases among the Chinese population.
Authors: Ling-Zhi Ma; Fu-Rong Sun; Zuo-Teng Wang; Lin Tan; Xiao-He Hou; Ya-Nan Ou; Qiang Dong; Jin-Tai Yu; Lan Tan Journal: Ann Transl Med Date: 2021-02