Constanze Hirsiger1, Patrick Roger Schmidlin2, Mary Michaelis3, Christian Hirsch4, Thomas Attin5, Christian Heumann6, Sophie Doméjean7, Christian Ralf Gernhardt8. 1. Clinic of Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zürich, Plattenstrasse 33, 8032, Zürich Switzerland. Electronic address: constanze.hirsiger@zzm.uzh.ch. 2. Clinic of Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zürich, Plattenstrasse 33, 8032, Zürich Switzerland. Electronic address: patrick.schmidlin@zzm.uzh.ch. 3. Department of Operative Dentistry and Periodontology, School of Dental Medicine, Martin-Luther-University, Magdeburger Strasse 16, 06120, Halle, Germany. Electronic address: mary.michaelis@uk-halle.de. 4. Department of Pediatric Dentistry, University School of Dentistry, Liebigstraße 10 - 14, 04103, Leipzig, Germany. Electronic address: kizhk@medizin.uni-leipzig.de. 5. Clinic of Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zürich, Plattenstrasse 33, 8032, Zürich Switzerland. Electronic address: thomas.attin@zzm.uzh.ch. 6. Department of Statistics, Ludwig-Maximilian-University, Ludwigstrasse 33, 80539, Munich, Germany. Electronic address: christian.heumann@stat.uni-muenchen.de. 7. Univ Clermont Auvergne, UFR d'Odontologie; Centre de Recherche en Odontologie Clinique EA 4847, Rue de Braga 2, F-63000 Clermont-Ferrand; CHU Estaing Clermont-Ferrand, Service d'Odontologie, Hôtel-, F-63001, Clermont-Ferrand, France. Electronic address: sophie.domejean@uca.fr. 8. Department of Operative Dentistry and Periodontology, School of Dental Medicine, Martin-Luther-University, Magdeburger Strasse 16, 06120, Halle, Germany. Electronic address: christian.gernhardt@uk-halle.de.
Abstract
OBJECTIVES: To assess the efficacy of 8% arginine containing prophylaxis products over 24 weeks in subjects with dentin hypersensitivity (DH). METHODS:297 patients with established DH (Schiff score 2, 3) in three European study centers were randomly assigned to either 8% arginine and calcium carbonate in-office prophylaxis paste and the respective toothpaste (test group) or fluoride-free prophylaxis paste and sodium monoflourophosphate toothpaste as a negative control group. Air blast (Schiff Score) and tactile (Visual Analog Scale) sensitivity scores were assessed at baseline (BL_0), after single application of the prophylaxis paste (BL_1) and after 4, 8, and 24 weeks of continuous at-home use of the toothpaste. RESULTS:273 subjects completed the study. Test and control group presented statistically significant percentage reductions (t-test, p < 0.05) in Schiff Score at BL_1 and at 24 weeks relative to BL_0 (difference in %; test group: -23.6, -44.9, control group: -8.8, -32.7). The pooled Schiff Score for the two evaluated teeth yielded a significantly greater alleviation of DH in the test group than in the control group at all evaluation appointments (Ancova, p < 0.05; difference in %: 15.3, 7.4, 10.6, 17.2). CONCLUSIONS: A significant relief of DH was demonstrated after application of the 8% arginine prophylaxis products over 24 weeks compared to a negative control. CLINICAL SIGNIFICANCE: Whilst DH is influencing patients' eating, drinking and tooth brushing habits as well as social life interactions it is important that clinicians are able to offer evidence based immediate and long-lasting treatment methods in order to manage their patients' discomfort.
RCT Entities:
OBJECTIVES: To assess the efficacy of 8% arginine containing prophylaxis products over 24 weeks in subjects with dentin hypersensitivity (DH). METHODS: 297 patients with established DH (Schiff score 2, 3) in three European study centers were randomly assigned to either 8% arginine and calcium carbonate in-office prophylaxis paste and the respective toothpaste (test group) or fluoride-free prophylaxis paste and sodium monoflourophosphate toothpaste as a negative control group. Air blast (Schiff Score) and tactile (Visual Analog Scale) sensitivity scores were assessed at baseline (BL_0), after single application of the prophylaxis paste (BL_1) and after 4, 8, and 24 weeks of continuous at-home use of the toothpaste. RESULTS: 273 subjects completed the study. Test and control group presented statistically significant percentage reductions (t-test, p < 0.05) in Schiff Score at BL_1 and at 24 weeks relative to BL_0 (difference in %; test group: -23.6, -44.9, control group: -8.8, -32.7). The pooled Schiff Score for the two evaluated teeth yielded a significantly greater alleviation of DH in the test group than in the control group at all evaluation appointments (Ancova, p < 0.05; difference in %: 15.3, 7.4, 10.6, 17.2). CONCLUSIONS: A significant relief of DH was demonstrated after application of the 8% arginine prophylaxis products over 24 weeks compared to a negative control. CLINICAL SIGNIFICANCE: Whilst DH is influencing patients' eating, drinking and tooth brushing habits as well as social life interactions it is important that clinicians are able to offer evidence based immediate and long-lasting treatment methods in order to manage their patients' discomfort.