Ashish J Mathew1,2, Simon Krabbe3,4, Richard Kirubakaran3,4, Andrew J Barr3,4, Philip G Conaghan3,4, Paul Bird3,4, Mikkel Østergaard3,4. 1. From the Department of Clinical Immunology and Rheumatology, Christian Medical College; Cochrane South Asia, Christian Medical College, Vellore, India; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; Copenhagen Center for Arthritis Research (COPECARE), Copenhagen; Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup, Glostrup, Denmark; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds Teaching Hospitals National Health Service (NHS) Trust; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; Division of Medicine, University of New South Wales, Sydney, Australia. ashishjacobmathew@gmail.com. 2. A.J. Mathew, MBBS, DNB, DM, Associate Professor, Department of Clinical Immunology and Rheumatology, Christian Medical College, and PhD Fellow, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, and COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup; S. Krabbe, MD, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, and COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup; R. Kirubakaran, BSc, MSc, Biostatistician, Cochrane South Asia, Christian Medical College; A.J. Barr, MRCP, PhD, Consultant Rheumatologist and Honorary Senior Lecturer, NIHR Leeds BRC, Leeds Teaching Hospitals NHS Trust; P.G. Conaghan, MBBS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC; P. Bird, B Med (Hons), FRACP, PhD, Grad Dip MRI, Associate Professor, Division of Medicine, University of New South Wales; M. Østergaard, MD, PhD, DMSc, Professor, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, and COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup. ashishjacobmathew@gmail.com. 3. From the Department of Clinical Immunology and Rheumatology, Christian Medical College; Cochrane South Asia, Christian Medical College, Vellore, India; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; Copenhagen Center for Arthritis Research (COPECARE), Copenhagen; Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup, Glostrup, Denmark; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds Teaching Hospitals National Health Service (NHS) Trust; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; Division of Medicine, University of New South Wales, Sydney, Australia. 4. A.J. Mathew, MBBS, DNB, DM, Associate Professor, Department of Clinical Immunology and Rheumatology, Christian Medical College, and PhD Fellow, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, and COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup; S. Krabbe, MD, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, and COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup; R. Kirubakaran, BSc, MSc, Biostatistician, Cochrane South Asia, Christian Medical College; A.J. Barr, MRCP, PhD, Consultant Rheumatologist and Honorary Senior Lecturer, NIHR Leeds BRC, Leeds Teaching Hospitals NHS Trust; P.G. Conaghan, MBBS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC; P. Bird, B Med (Hons), FRACP, PhD, Grad Dip MRI, Associate Professor, Division of Medicine, University of New South Wales; M. Østergaard, MD, PhD, DMSc, Professor, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, and COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup.
Abstract
OBJECTIVE: A systematic literature review was performed to document published magnetic resonance imaging (MRI) lesion definitions and scoring systems for enthesitis in spondyloarthritis (SpA). METHODS: PubMed, Embase, and Cochrane Library databases were searched for original publications involving adult patients with SpA undergoing MRI of axial/peripheral joints. Selected articles were assessed for quality using a standardized assessment tool and metric indices. RESULTS: Considering the heterogeneous design, quality, and outcome measures of studies, statistical data pooling was considered inappropriate. A qualitative narrative of results was undertaken based on study designs. CONCLUSION: Lack of a comprehensive, validated score warrants additional research to develop an MRI enthesitis scoring system. PROSPERO registration number: CRD42018090537.
OBJECTIVE: A systematic literature review was performed to document published magnetic resonance imaging (MRI) lesion definitions and scoring systems for enthesitis in spondyloarthritis (SpA). METHODS: PubMed, Embase, and Cochrane Library databases were searched for original publications involving adult patients with SpA undergoing MRI of axial/peripheral joints. Selected articles were assessed for quality using a standardized assessment tool and metric indices. RESULTS: Considering the heterogeneous design, quality, and outcome measures of studies, statistical data pooling was considered inappropriate. A qualitative narrative of results was undertaken based on study designs. CONCLUSION: Lack of a comprehensive, validated score warrants additional research to develop an MRI enthesitis scoring system. PROSPERO registration number: CRD42018090537.
Entities:
Keywords:
ENTHESOPATHY; INFLAMMATION; MAGNETIC RESONANCE IMAGING; OMERACT; SPONDYLOARTHROPATHY
Authors: Ashish J Mathew; Simon Krabbe; Iris Eshed; Robert Gw Lambert; Jean-Denis Laredo; Walter P Maksymowych; Frederique Gandjbakhch; Yasser Emad; Maria Simona Stoenoiu; Violaine Foltz; Paul Bird; Philippe Carron; Joel Paschke; Philip G Conaghan; Susanne J Pedersen; Daniel Glinatsi; Mikkel Østergaard Journal: RMD Open Date: 2020-02-11