Literature DB >> 30709442

Mesenchymal Tumors with EWSR1 Gene Rearrangements.

Khin Thway1, Cyril Fisher2.   

Abstract

Among the various genes that can be rearranged in soft tissue neoplasms associated with nonrandom chromosomal translocations, EWSR1 is the most frequent one to partner with other genes to generate recurrent fusion genes. This leads to a spectrum of clinically and pathologically diverse mesenchymal and nonmesenchymal neoplasms, variably manifesting as small round cell, spindle cell, clear cell or adipocytic tumors, or tumors with distinctive myxoid stroma. This review summarizes the growing list of mesenchymal neoplasms that are associated with EWSR1 gene rearrangements.
Copyright © 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Angiomatoid fibrous histiocytoma; Clear cell sarcoma; Desmoplastic small round cell tumor; EWSR1; EWSR1–NFATC2; Myoepithelial tumor; Myxoid liposarcoma; Sarcoma

Mesh：

Substances：

Year:  2019        PMID： 30709442     DOI： 10.1016/j.path.2018.10.007

Source DB:  PubMed          Journal:  Surg Pathol Clin        ISSN： 1875-9157


  14 in total

Review 1.  EWSR1/FUS-NFATc2 rearranged round cell sarcoma: clinicopathological series of 4 cases and literature review.

Authors:  Julio A Diaz-Perez; G Petur Nielsen; Cristina Antonescu; Martin S Taylor; Santiago A Lozano-Calderon; Andrew E Rosenberg
Journal:  Hum Pathol       Date:  2019-05-09       Impact factor: 3.466

2.  EWSR1 overexpression is a pro-oncogenic event in multiple myeloma.

Authors:  Daichi Nishiyama; Yoshiaki Chinen; Reiko Isa; Yuto Fujibayashi; Saeko Kuwahara-Ota; Junko Yamaguchi; Tomoko Takimoto-Shimomura; Yayoi Matsumura-Kimoto; Taku Tsukamoto; Yuji Shimura; Tsutomu Kobayashi; Shigeo Horiike; Masafumi Taniwaki; Hiroshi Handa; Junya Kuroda
Journal:  Int J Hematol       Date:  2020-10-23       Impact factor: 2.490

3.  Multiscale-omic assessment of EWSR1-NFATc2 fusion positive sarcomas identifies the mTOR pathway as a potential therapeutic target.

Authors:  Nathan D Seligson; Richard D Maradiaga; Colin M Stets; Howard M Katzenstein; Sherri Z Millis; Alan Rogers; John L Hays; James L Chen
Journal:  NPJ Precis Oncol       Date:  2021-05-21

4.  Distinct clinicopathological features of pulmonary primary angiomatoid fibrous histiocytoma: A report of four new cases and review of the literature.

Authors:  Zheng Wang; Liping Zhang; Li Ren; Dongge Liu; Jun Du; Min Zhang; Ge Lou; Ying Song; Yin Wang; Chunyan Wu; Guiping Han
Journal:  Thorac Cancer       Date:  2020-12-12       Impact factor: 3.500

Review 5.  A Case Series of Metastatic Malignant Gastrointestinal Neuroectodermal Tumors and Comprehensive Genomic Profiling Analysis of 20 Cases.

Authors:  Taylor Kandler; Eliane Cortez; Lani Clinton; Amanda Hemmerich; Osama Ahmed; Ralph Wong; Taylor Forns; Andrea J MacNeill; Trevor D Hamilton; Mohammadali Khorasani; Xiaolan Feng
Journal:  Curr Oncol       Date:  2022-02-21       Impact factor: 3.677

Review 6.  Fusion genes as biomarkers in pediatric cancers: A review of the current state and applicability in diagnostics and personalized therapy.

Authors:  Neetha Nanoth Vellichirammal; Nagendra K Chaturvedi; Shantaram S Joshi; Donald W Coulter; Chittibabu Guda
Journal:  Cancer Lett       Date:  2020-11-25       Impact factor: 9.756

7.  DICER1-associated metastatic abdominopelvic primitive neuroectodermal tumor with an EWSR1 rearrangement in a 16-yr-old female.

Authors:  Alessia Pancaldi; Lei Peng; Daniel S Rhee; Emily Dunn; Jessica A Forcucci; Deborah Belchis; Christine A Pratilas
Journal:  Cold Spring Harb Mol Case Stud       Date:  2020-10-07

Review 8.  The spectrum of rare central nervous system (CNS) tumors with EWSR1-non-ETS fusions: experience from three pediatric institutions with review of the literature.

Authors:  Oscar Lopez-Nunez; Barbara Cafferata; Mariarita Santi; Sarangarajan Ranganathan; Thomas M Pearce; Scott M Kulich; Kelly M Bailey; Alberto Broniscer; Sabrina Rossi; Angelica Zin; MacLean P Nasrallah; Marilyn M Li; Yiming Zhong; Evelina Miele; Rita Alaggio; Lea F Surrey
Journal:  Brain Pathol       Date:  2020-11-06       Impact factor: 6.508

9.  EWSR1 rearrangement in papillary thyroid microcarcinoma is related to classic morphology and the presence of small-cell phenotype.

Authors:  Bozidar Kovacevic; Ana Caramelo; Vesna Skuletic; Snezana Cerovic; Catarina Eloy
Journal:  Bosn J Basic Med Sci       Date:  2022-02-01       Impact factor: 3.363

10.  Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors.

Authors:  Philipp Sievers; Sophie C Henneken; Kristian W Pajtler; Felix Sahm; Christina Blume; Martin Sill; Daniel Schrimpf; Damian Stichel; Konstantin Okonechnikov; David E Reuss; Julia Benzel; Kendra K Maaß; Marcel Kool; Dominik Sturm; Tuyu Zheng; David R Ghasemi; Patricia Kohlhof-Meinecke; Ofelia Cruz; Mariona Suñol; Cinzia Lavarino; Viktoria Ruf; Henning B Boldt; Mélanie Pagès; Celso Pouget; Leonille Schweizer; Mariëtte E G Kranendonk; Noreen Akhtar; Stephanie Bunkowski; Christine Stadelmann; Ulrich Schüller; Wolf C Mueller; Hildegard Dohmen; Till Acker; Patrick N Harter; Christian Mawrin; Rudi Beschorner; Sebastian Brandner; Matija Snuderl; Zied Abdullaev; Kenneth Aldape; Mark R Gilbert; Terri S Armstrong; David W Ellison; David Capper; Koichi Ichimura; Guido Reifenberger; Richard G Grundy; Nada Jabado; Lenka Krskova; Michal Zapotocky; Ales Vicha; Pascale Varlet; Pieter Wesseling; Stefan Rutkowski; Andrey Korshunov; Wolfgang Wick; Stefan M Pfister; David T W Jones; Andreas von Deimling
Journal:  Acta Neuropathol       Date:  2021-08-05       Impact factor: 17.088
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