M Peters1,2,3, J P van den Bergh4,5,6,7, P Geusens4,8,6, A Scharmga4,8,5, D Loeffen9, R Weijers9, B van Rietbergen10,11, A van Tubergen4,8. 1. Division of Rheumatology, Department of Internal Medicine, Maastricht University Medical Center, P.O. Box 5800, NL-6202 AZ, Maastricht, The Netherlands. michiel.peters@maastrichtuniversity.nl. 2. Research School CAPHRI, School for Public Health and Primary Care, Maastricht, The Netherlands. michiel.peters@maastrichtuniversity.nl. 3. NUTRIM School of Nutrition & Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands. michiel.peters@maastrichtuniversity.nl. 4. Division of Rheumatology, Department of Internal Medicine, Maastricht University Medical Center, P.O. Box 5800, NL-6202 AZ, Maastricht, The Netherlands. 5. NUTRIM School of Nutrition & Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands. 6. Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium. 7. Department of Internal Medicine, VieCuri Medical Center, Venlo, The Netherlands. 8. Research School CAPHRI, School for Public Health and Primary Care, Maastricht, The Netherlands. 9. Department of Radiology, Maastricht University Medical Center, Maastricht, The Netherlands. 10. Faculty of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands. 11. Department of Orthopaedic Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.
Abstract
OBJECTIVES: The purpose of the study was to prospectively investigate change (repair or progression) in the number, surface area and volume of cortical interruptions, bone density (vBMD) and micro-structural parameters assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) in finger joints of patients with rheumatoid arthritis (RA) treated with synthetic disease modifying anti-rheumatic drugs (sDMARDs) and/or biologic DMARDs (bDMARDs) over a 1-year follow-up period, and in comparison with healthy subjects (HS). METHODS: Thirty-two patients with RA (221 joints, 53% on bDMARDs) and 32 HS (117 joints) were assessed at baseline and after 1 year using semi-automatic analysis of HR-pQCT images. Mean changes (group level) and the proportion of joints (joint level) with changes beyond the least significant change were calculated. RESULTS: At baseline, 530 interruptions were identified in patients, and 136 in HS. The mean of the interruption parameters did not significantly change in either group Mean vBMD decreased more in patients than in HS (- 4.4 versus - 1.1 mgHA/cm3, respectively). In patients versus HS, proportionally more joints showed repair in interruption volume (6.6% versus 1.7%, respectively) and loss of vBMD (26.7% versus 12.9%, respectively). In patients on sDMARDs versus patients on bDMARDs, proportionally more joints showed progression in the number of interruptions and loss of vBMD (6.1% versus 1.8% and 31.3% versus 17.2%, respectively). CONCLUSIONS: HR-pQCT is able to quantify bone repair and progression. Cortical interruption-, vBMD-, and micro-structure were impaired in RA, of which vBMD and micro-structure further deteriorated, particularly in patients on sDMARDs.
OBJECTIVES: The purpose of the study was to prospectively investigate change (repair or progression) in the number, surface area and volume of cortical interruptions, bone density (vBMD) and micro-structural parameters assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) in finger joints of patients with rheumatoid arthritis (RA) treated with synthetic disease modifying anti-rheumatic drugs (sDMARDs) and/or biologic DMARDs (bDMARDs) over a 1-year follow-up period, and in comparison with healthy subjects (HS). METHODS: Thirty-two patients with RA (221 joints, 53% on bDMARDs) and 32 HS (117 joints) were assessed at baseline and after 1 year using semi-automatic analysis of HR-pQCT images. Mean changes (group level) and the proportion of joints (joint level) with changes beyond the least significant change were calculated. RESULTS: At baseline, 530 interruptions were identified in patients, and 136 in HS. The mean of the interruption parameters did not significantly change in either group Mean vBMD decreased more in patients than in HS (- 4.4 versus - 1.1 mgHA/cm3, respectively). In patients versus HS, proportionally more joints showed repair in interruption volume (6.6% versus 1.7%, respectively) and loss of vBMD (26.7% versus 12.9%, respectively). In patients on sDMARDs versus patients on bDMARDs, proportionally more joints showed progression in the number of interruptions and loss of vBMD (6.1% versus 1.8% and 31.3% versus 17.2%, respectively). CONCLUSIONS:HR-pQCT is able to quantify bone repair and progression. Cortical interruption-, vBMD-, and micro-structure were impaired in RA, of which vBMD and micro-structure further deteriorated, particularly in patients on sDMARDs.
Entities:
Keywords:
Bone mineral density; Cortical interruptions; Disease modifying anti-rheumatic drugs; High-resolution peripheral quantitative computed tomography; Rheumatoid arthritis
Authors: Lukas Folle; Timo Meinderink; David Simon; Anna-Maria Liphardt; Gerhard Krönke; Georg Schett; Arnd Kleyer; Andreas Maier Journal: Sci Rep Date: 2021-05-06 Impact factor: 4.379
Authors: Scott C Brunet; Michael T Kuczynski; Jennifer L Bhatla; Sophie Lemay; Yves Pauchard; Peter Salat; Cheryl Barnabe; Sarah L Manske Journal: BMC Med Imaging Date: 2020-04-07 Impact factor: 1.930