| Literature DB >> 30706458 |
Guoqiao Zheng1,2, Subhayan Chattopadhyay1,2, Amit Sud1,3, Kristina Sundquist4,5,6, Jan Sundquist4,5,6, Asta Försti1,4, Richard Houlston3,7, Akseli Hemminki8,9, Kari Hemminki1,4.
Abstract
Improvement of survival in lymphocytic leukaemia has been accompanied by the occurrence of second primary cancer (SPCs). Based on Swedish Family Cancer Database, we applied bi-directional analyses in which relative risks (RRs) were calculated for any SPCs in patients with chronic lymphocytic leukaemia (CLL), acute lymphoblastic leukaemia (ALL) and hairy cell leukaemia (HCL) and the risks of these leukaemias as SPCs. After CLL, RRs were significant for 20 SPCs, and high for skin squamous cell cancer (24·58 for in situ and 7·63 for invasive), Merkel cell carcinoma (14·36), Hodgkin lymphoma (7·16) and Kaposi sarcoma (6·76). Conversely, 15 CLL cancer pairs were reciprocally increased. The increased risks were reciprocal for ALL and four cancers. RR for ALL was 15·35 after myeloid neoplasia. HCL showed reciprocally increased RRs with non-Hodgkin lymphoma and melanoma. The concordance between RRs for bi-directional associations between CLL and different cancers, and HCL and different cancers was highly significant. For CLL (also for HCL), the bi-directional risks with skin cancers and other immune-related cancers suggest the probable involvement of immune dysfunction. For ALL, treatment may contribute to risks of multiple SPCs. Increased risk of ALL after haematological neoplasms may indicate bone marrow dysfunction. These findings may help guide treatment decisions and prognostic assessment.Entities:
Keywords: B cell leukaemia; bi-directional risk; immune suppression; mechanistic implication; second cancers
Mesh：
Year: 2019 PMID： 30706458 DOI： 10.1111/bjh.15777
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998