Literature DB >> 30706195

The interferon antagonistic activities of the V proteins of NDV correlated with their virulence.

Xinglong Wang1, Ruiyi Dang2, Zengqi Yang3.   

Abstract

Protein V of Newcastle disease virus (NDV) serves as interferon (IFN) antagonist, and NDV stains with different pathogenicity show different abilities in inhibition IFN expression. To further reveal the relationship between viral virulence and their IFN-antagonistic activity derived from protein V, six NDV strains with three different pathotypes were used in this study and their V gene were cloned into eukaryotic expression vector. The V gene derived from different NDV strains were expressed in same level in cells after transfection according to the results from Western blotting. And these proteins showed different interferon-antagonistic activities based on interferon expression using Luciferase Reporter Assay and ELISA. The expression of IFN and viral virulence index, mean death time, have a good linear relationship indicating a good correlation between viral virulence and IFN antagonism of their V Protein.

Entities:  

Keywords:  Antagonistic interferon; Newcastle disease virus (NDV); Non-structural protein; Protein V; Virulence

Mesh：

Substances：

Year:  2019        PMID： 30706195     DOI： 10.1007/s11262-019-01637-3

Source DB:  PubMed          Journal:  Virus Genes        ISSN： 0920-8569            Impact factor:   2.332


  10 in total

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5.  Newcastle disease virus V protein is associated with viral pathogenesis and functions as an alpha interferon antagonist.

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Journal:  J Virol       Date:  2003-08       Impact factor: 5.103

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  10 in total
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Review 2.  Breaking Therapy Resistance: An Update on Oncolytic Newcastle Disease Virus for Improvements of Cancer Therapy.

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  3 in total

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