Marcello Bosi1, Giulia Milioli2, Liborio Parrino3, Francesco Fanfulla4, Sara Tomassetti1, Andrea Melpignano3, Irene Trippi3, Anna Elisabetta Vaudano3, Claudia Ravaglia1, Susanna Mascetti1, Venerino Poletti5. 1. Department of Diseases of the Thorax, GB Morgagni Hospital, Asl Romagna, Forlì, Italy. 2. Sleep Disorders Center, Department of Medicine and Surgery, University of Parma, Italy. Electronic address: giulia.milioli@gmail.com. 3. Sleep Disorders Center, Department of Medicine and Surgery, University of Parma, Italy. 4. Sleep Medicine Unit Istituti Clinici Scientifici Maugeri, IRCCS, Scientific Institute of Pavia, Italy. 5. Department of Diseases of the Thorax, GB Morgagni Hospital, Asl Romagna, Forlì, Italy; Department of Respiratory Diseases & Allerg, Aarhus University Hospital, Aarhus, Denmark.
Abstract
PURPOSE: the study aims at describing the role of sleep disordered breathing (SDB) on daytime symptoms, quality of sleep and quality of life (QoL) in patients with moderate-severe IPF. METHODS: we enrolled 34 consecutive room air breathing IPF outpatients who received a full-night polysomnography. The following questionnaires were administered: Epworth Sleepiness Score (ESS), Pittsburg Sleep Quality Index (PSQI), StGeorge's Questionnaire (StGQ). RESULTS: patients were classified in 3 groups:Group A (NO-SDB, 9 patients), Group B(OSAS without sleep-related hypoxemia, 17 patients), Group C(OSAS with sleep-related hypoxemia, 8 patients). Although sleep parameters showed no significant differences among the 3 groups, worse measures were found in group C. 50% of patients (17/34) reported a StGQ score indicating a reduced QoL and the StGQ score was significantly higher in group C patients compared to group A (p < 0.05). In the stepwise multiple regression analysis, 75% of StGQ score variability was significantly predicted by FVC(Forced Vital Capacity) %, DLco (diffusion lung capacity for carbon monoxide)%, PSQI and ESS. CONCLUSIONS: in patients with IPF both subjective and polysomnographic poor sleep quality are extremely common features, they are predicted by variables associated with SBD severity and are linked to low QoL. IPF with more severe SDB present poor sleep quality and a worse QoL compared to SDB-free or OSAS-only.
PURPOSE: the study aims at describing the role of sleep disordered breathing (SDB) on daytime symptoms, quality of sleep and quality of life (QoL) in patients with moderate-severe IPF. METHODS: we enrolled 34 consecutive room air breathing IPF outpatients who received a full-night polysomnography. The following questionnaires were administered: Epworth Sleepiness Score (ESS), Pittsburg Sleep Quality Index (PSQI), StGeorge's Questionnaire (StGQ). RESULTS:patients were classified in 3 groups:Group A (NO-SDB, 9 patients), Group B(OSAS without sleep-related hypoxemia, 17 patients), Group C(OSAS with sleep-related hypoxemia, 8 patients). Although sleep parameters showed no significant differences among the 3 groups, worse measures were found in group C. 50% of patients (17/34) reported a StGQ score indicating a reduced QoL and the StGQ score was significantly higher in group C patients compared to group A (p < 0.05). In the stepwise multiple regression analysis, 75% of StGQ score variability was significantly predicted by FVC(Forced Vital Capacity) %, DLco (diffusion lung capacity for carbon monoxide)%, PSQI and ESS. CONCLUSIONS: in patients with IPF both subjective and polysomnographic poor sleep quality are extremely common features, they are predicted by variables associated with SBD severity and are linked to low QoL. IPF with more severe SDB present poor sleep quality and a worse QoL compared to SDB-free or OSAS-only.
Authors: Filip Franciszek Karuga; Piotr Kaczmarski; Bartosz Szmyd; Piotr Białasiewicz; Marcin Sochal; Agata Gabryelska Journal: J Clin Med Date: 2022-08-26 Impact factor: 4.964