Marianna Liparoti1, Marida Della Corte2, Rosaria Rucco3, Pierpaolo Sorrentino4, Maddalena Sparaco2, Rocco Capuano5, Roberta Minino1, Luigi Lavorgna5, Valeria Agosti1, Giuseppe Sorrentino6, Simona Bonavita5. 1. Department of Motor Sciences and Wellness, University of Naples "Parthenope", Via Medina 40, Naples 80133, Italy. 2. Department of Advanced Medical and Surgical Sciences, - MRI Research Center SUN-FISM, University of Campania "Luigi Vanvitelli", P.zza Miraglia 2, Naples 80138, Italy; Hermitage Capodimonte Hospital, Via Cupa delle Tozzole 2, Naples 80131, Italy. 3. Department of Motor Sciences and Wellness, University of Naples "Parthenope", Via Medina 40, Naples 80133, Italy; Institute of Applied Sciences and Intelligent Systems - CNR, Pozzuoli, Italy. 4. Institute of Applied Sciences and Intelligent Systems - CNR, Pozzuoli, Italy; Department of Engineering - University of Naples "Parthenope", Centro Direzionale Isola C4, Naples 80133, Italy. 5. Department of Advanced Medical and Surgical Sciences, - MRI Research Center SUN-FISM, University of Campania "Luigi Vanvitelli", P.zza Miraglia 2, Naples 80138, Italy. 6. Department of Motor Sciences and Wellness, University of Naples "Parthenope", Via Medina 40, Naples 80133, Italy; Hermitage Capodimonte Hospital, Via Cupa delle Tozzole 2, Naples 80131, Italy; Institute of Applied Sciences and Intelligent Systems - CNR, Pozzuoli, Italy. Electronic address: giuseppe.sorrentino@uniparthenope.it.
Abstract
BACKGROUND: People with Relapsing-Remitting Multiple Sclerosis (pwRR-MS), may be affected by subclinical gait impairment. The Expanded Disability Status Scale, the most used scale to assess MS related disability, may be insensitive to subclinical gait disability. Minor gait abnormalities may be detected by three Dimensional-Gait Analysis (3D-GA). OBJECTIVES: To investigate gait pattern in minimally disabled pwRR-MS by 3D-GA during walking (single task, SinT), and cognitive dual tasks (CogDT) and to evaluate correlations between altered gait parameters, cognitive scores, lesion load (LL) and brain atrophy measures. METHODS: Twenty-two pwRR-MS and twenty-one healthy controls (HCs), underwent neuropsychological (NP) evaluation, and brain MRI to assess brain volumes and lesion load (only in pwRR-MS) and 3D-GA. RESULTS: Both pwRR-MS and HCs were considered cognitively preserved (CP). During SinT pwRR-MS, compared to HCs, showed an impairment of velocity (increase of cycle time), stability (increase of stance time, swing time and coefficients of variability (CV) of swing time) and kinematic (increase of ankle dorsiflexion) parameters. During CogDT, the changes of velocity and stability parameters observed in SinT were confirmed. Moreover, a statistically significant increase of the double limb support was observed. Regarding the kinematic parameters, during CogDT, an increase of ankle dorsiflexion during mid and terminal stance phases of gait cycle was observed. No significant correlations were found between gait abnormalities and cognitive status or MRI structural damage in both groups. CONCLUSIONS: The subclinical abnormal gait in asymptomatic and CP pwRR-MS, may be detected by 3D-GA.
BACKGROUND:People with Relapsing-Remitting Multiple Sclerosis (pwRR-MS), may be affected by subclinical gait impairment. The Expanded Disability Status Scale, the most used scale to assess MS related disability, may be insensitive to subclinical gait disability. Minor gait abnormalities may be detected by three Dimensional-Gait Analysis (3D-GA). OBJECTIVES: To investigate gait pattern in minimally disabled pwRR-MS by 3D-GA during walking (single task, SinT), and cognitive dual tasks (CogDT) and to evaluate correlations between altered gait parameters, cognitive scores, lesion load (LL) and brain atrophy measures. METHODS: Twenty-two pwRR-MS and twenty-one healthy controls (HCs), underwent neuropsychological (NP) evaluation, and brain MRI to assess brain volumes and lesion load (only in pwRR-MS) and 3D-GA. RESULTS: Both pwRR-MS and HCs were considered cognitively preserved (CP). During SinT pwRR-MS, compared to HCs, showed an impairment of velocity (increase of cycle time), stability (increase of stance time, swing time and coefficients of variability (CV) of swing time) and kinematic (increase of ankle dorsiflexion) parameters. During CogDT, the changes of velocity and stability parameters observed in SinT were confirmed. Moreover, a statistically significant increase of the double limb support was observed. Regarding the kinematic parameters, during CogDT, an increase of ankle dorsiflexion during mid and terminal stance phases of gait cycle was observed. No significant correlations were found between gait abnormalities and cognitive status or MRI structural damage in both groups. CONCLUSIONS: The subclinical abnormal gait in asymptomatic and CP pwRR-MS, may be detected by 3D-GA.
Authors: Jiangshan Zhan; Vladislav Yakimov; Sebastian Rühling; Felix Fischbach; Elena Nikolova; Sarah Joost; Hannes Kaddatz; Theresa Greiner; Julia Frenz; Carsten Holzmann; Markus Kipp Journal: Cells Date: 2019-11-14 Impact factor: 6.600
Authors: Julia Schüler; Wanja Wolff; Julian Pfeifer; Romina Rihm; Jessica Reichel; Gerhard Rothacher; Christian Dettmers Journal: Front Psychol Date: 2021-01-28