Literature DB >> 30703171

Correction: Reelin controls the positioning of brainstem serotonergic raphe neurons.

Reham Shehabeldin, David Lutz, Meliha Karsak, Michael Frotscher, Kerstin Krieglstein, Ahmed Sharaf.   

Abstract

[This corrects the article DOI: 10.1371/journal.pone.0200268.].

Entities:  

Year:  2019        PMID: 30703171      PMCID: PMC6355025          DOI: 10.1371/journal.pone.0211849

Source DB:  PubMed          Journal:  PLoS One        ISSN: 1932-6203            Impact factor:   3.240


Fig 7 presents the 5-HT positive projections of the hindbrain serotonergic raphe neurons to the hippocampus in both wild type and reeler at postnatal day 20 (P20). The authors later discovered that the time point of used tissue was not from P20 but younger mice (P5). Please find the correct Fig 7 here, generated from brain tissue of WT and reeler mice of the correct age (P20).
Fig 7

Altered serotonergic innervation of the reeler hippocampus at P20.

(A) Expression of Cxcr4-eGFP in Cajal-Retzius (CR) cells of the dentate gyrus. (B-D) Serotonergic fibers are distributed throughout hippocampal layers, and 5-HT positive fibers and Cajal-Retzius cells overlap. (E) Scattered distribution of Cajal-Retzius cells in reeler hippocampus. (F-H) Severe reduction of serotonergic fibers in Cxcr4-eGFP hippocampal reeler mice. CA1, cornu ammonis area 1; CA3, cornu ammonis area 3; DG, dentate gyrus. Scale bar for A-D: 100μm.

Altered serotonergic innervation of the reeler hippocampus at P20.

(A) Expression of Cxcr4-eGFP in Cajal-Retzius (CR) cells of the dentate gyrus. (B-D) Serotonergic fibers are distributed throughout hippocampal layers, and 5-HT positive fibers and Cajal-Retzius cells overlap. (E) Scattered distribution of Cajal-Retzius cells in reeler hippocampus. (F-H) Severe reduction of serotonergic fibers in Cxcr4-eGFP hippocampal reeler mice. CA1, cornu ammonis area 1; CA3, cornu ammonis area 3; DG, dentate gyrus. Scale bar for A-D: 100μm. In Fig 10, Fig 10H and Fig 10K were reversed accidentally. Fig 10H describes SERT positive fibers of serotonergic neurons into the hippocampus of reeler mice whereas Fig 10K describes SERT positive fibers of the serotonergic neurons into the hippocampus of WT mice. Please find the correct Fig 10 here, where the lower image (Fig 10K) has been be switched to the upper lane and vice versa.
Fig 10

Reduction of serotonin transporter protein (SERT) expression in brain regions of reeler mice.

A. Western blot analysis showed reduction of SERT protein levels in reeler cortex, hippocampus, and Cerebellum as compared to wild type. (B-G) reduction of SERT expression in reeler cortex as well as in hippocampal slices as observed in (H-M) as compared to the same matched wild type littermates at P30. Hippo = hippocampus; Cereb = Cerebellum. Scale bar: 100 μm.

Reduction of serotonin transporter protein (SERT) expression in brain regions of reeler mice.

A. Western blot analysis showed reduction of SERT protein levels in reeler cortex, hippocampus, and Cerebellum as compared to wild type. (B-G) reduction of SERT expression in reeler cortex as well as in hippocampal slices as observed in (H-M) as compared to the same matched wild type littermates at P30. Hippo = hippocampus; Cereb = Cerebellum. Scale bar: 100 μm.
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1.  Reelin controls the positioning of brainstem serotonergic raphe neurons.

Authors:  Reham Shehabeldin; David Lutz; Meliha Karsak; Michael Frotscher; Kerstin Krieglstein; Ahmed Sharaf
Journal:  PLoS One       Date:  2018-07-12       Impact factor: 3.240

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Review 1.  Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder.

Authors:  Ria Gupta; Sidharth Mehan; Swesha Chhabra; Aditi Giri; Kajal Sherawat
Journal:  Neurotox Res       Date:  2022-10-22       Impact factor: 3.978

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