| Literature DB >> 30703063 |
L Francisco Lorenzo-Martín1,2,3, Mauricio Menacho-Márquez1,2,3, Salvatore Fabbiano1,2, Omar Al-Massadi4,5,6, Antonio Abad1,2,3, Sonia Rodríguez-Fdez1,2, María A Sevilla1,2, María J Montero1,2, Carlos Diéguez4,5,6, Rubén Nogueiras4,5,6, Xosé R Bustelo1,2.
Abstract
Multiple crosstalk between peripheral organs and the nervous system are required to maintain physiological and metabolic homeostasis. Using Vav3-deficient mice as a model for chronic sympathoexcitation-associated disorders, we report here that afferent fibers of the hepatic branch of the vagus nerve are needed for the development of the peripheral sympathoexcitation, tachycardia, tachypnea, insulin resistance, liver steatosis and adipose tissue thermogenesis present in those mice. This neuronal pathway contributes to proper activity of the rostral ventrolateral medulla, a sympathoregulatory brainstem center hyperactive in Vav3-/- mice. Vagal afferent inputs are also required for the development of additional pathophysiological conditions associated with deregulated rostral ventrolateral medulla activity. By contrast, they are dispensable for other peripheral sympathoexcitation-associated disorders sparing metabolic alterations in liver.Entities:
Keywords: GABAergic signals; adipose tissue; brainstem; diabetes; hypertension; liver; metabolic syndrome; sympathetic system; thermogenesis; ventrolateral medulla
Mesh：
Substances：
Year: 2019 PMID： 30703063 PMCID： PMC6368248 DOI： 10.1530/JOE-18-0623
Source DB: PubMed Journal: J Endocrinol ISSN： 0022-0795 Impact factor: 4.286