Blandine de Lauzon-Guillain1,2,3, Yves Akoli Koudou1, Jérémie Botton1,4, Anne Forhan1,2, Sophie Carles1, Véronique Pelloux5,6,7, Karine Clément5,6,7, Ken K Ong8, Marie Aline Charles1,2, Barbara Heude1,2. 1. INSERM, UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center, Early Origin of the Child's Health and Development Team (ORCHAD), Paris, France. 2. Paris Descartes University, UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center, Paris, France. 3. INRA, U1125 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Early Origin of the Child's Health and Development Team (ORCHAD), Paris, France. 4. Faculty of Pharmacy, University of Paris-Sud, Université Paris-Saclay, France. 5. Institute of Cardiometabolism and Nutrition (ICAN), Paris, France. 6. INSERM, UMRS 1166, Nutriomic Team 6, Paris, France. 7. Sorbonne Universités, UPMC Université Paris 06, UMRS1166, Paris, France. 8. Medical Research Council Epidemiology Unit and Department of Paediatrics, University of Cambridge, Cambridge, UK.
Abstract
BACKGROUND: Many genetic polymorphisms identified by genome-wide association studies for adult body mass index (BMI) have been suggested to regulate food intake. OBJECTIVE: The objective was to study the associations between a genetic obesity risk score, appetitive traits, and growth of children up to age 5 years, with a longitudinal design. METHODS: In 1142 children from the Etude des Déterminants pre et post natals de la santé de l'ENfant (EDEN) birth cohort, a combined obesity risk-allele score (BMI genetic risk score [GRS]) was related to appetitive traits (energy intake up to 12 mo, a single item on appetite from 4 mo to 3 y, a validated appetite score at 5 y) using Poisson regressions with robust standard errors. The potential mediation of appetitive traits on the association between BMI-GRS and growth was assessed by the Sobel test. RESULTS: Children with a high BMI-GRS were more likely to have high energy intake at 1 year and high appetite at 2 and 5 years. High energy intake in infancy and high appetite from 1 year were related to higher subsequent BMI. High 2-year appetite seemed to partially mediate the associations between BMI-GRS and BMI from 2 to 5 years (all P ≤ 0.05). CONCLUSIONS: Genetic susceptibility to childhood obesity seems to be partially explained by appetitive traits in infancy, followed by an early childhood rise in BMI.
BACKGROUND: Many genetic polymorphisms identified by genome-wide association studies for adult body mass index (BMI) have been suggested to regulate food intake. OBJECTIVE: The objective was to study the associations between a genetic obesity risk score, appetitive traits, and growth of children up to age 5 years, with a longitudinal design. METHODS: In 1142 children from the Etude des Déterminants pre et post natals de la santé de l'ENfant (EDEN) birth cohort, a combined obesity risk-allele score (BMI genetic risk score [GRS]) was related to appetitive traits (energy intake up to 12 mo, a single item on appetite from 4 mo to 3 y, a validated appetite score at 5 y) using Poisson regressions with robust standard errors. The potential mediation of appetitive traits on the association between BMI-GRS and growth was assessed by the Sobel test. RESULTS:Children with a high BMI-GRS were more likely to have high energy intake at 1 year and high appetite at 2 and 5 years. High energy intake in infancy and high appetite from 1 year were related to higher subsequent BMI. High 2-year appetite seemed to partially mediate the associations between BMI-GRS and BMI from 2 to 5 years (all P ≤ 0.05). CONCLUSIONS: Genetic susceptibility to childhood obesity seems to be partially explained by appetitive traits in infancy, followed by an early childhood rise in BMI.
Authors: Claire Guivarch; Marie-Aline Charles; Anne Forhan; Ken K Ong; Barbara Heude; Blandine de Lauzon-Guillain Journal: Nutrients Date: 2021-04-26 Impact factor: 5.717