BACKGROUND: Interventional radiotherapy (brachytherapy; IRT) reemerged in the last decades as a potentially useful tool in head and neck oncology after a set of clear technical improvements were developed. METHODS: Sixty-one high dose ratio (HDR) IRT treatments were recommended and performed on 58 patients. We classified the cases into four relatively homogeneous groups based on the clinical needs that led to the recommended IRT. Also, we separately evaluated primary and recurrent cases. RESULTS: Disease-specific survival was significantly different among the four treatment groups. The group with the best prognosis was the cohort treated locally by exclusive interstitial IRT for resectable midface malignancies (2-year relapse-free survival = 82%, disease-specific survival = 89%). CONCLUSION: HDR IRT is a valuable tool in well-defined clinical situations and, in particular, in recurrences. In midface malignancies, it could become the preferred primary treatment.
BACKGROUND: Interventional radiotherapy (brachytherapy; IRT) reemerged in the last decades as a potentially useful tool in head and neck oncology after a set of clear technical improvements were developed. METHODS: Sixty-one high dose ratio (HDR) IRT treatments were recommended and performed on 58 patients. We classified the cases into four relatively homogeneous groups based on the clinical needs that led to the recommended IRT. Also, we separately evaluated primary and recurrent cases. RESULTS: Disease-specific survival was significantly different among the four treatment groups. The group with the best prognosis was the cohort treated locally by exclusive interstitial IRT for resectable midface malignancies (2-year relapse-free survival = 82%, disease-specific survival = 89%). CONCLUSION: HDR IRT is a valuable tool in well-defined clinical situations and, in particular, in recurrences. In midface malignancies, it could become the preferred primary treatment.
Authors: Roberto Gallus; Tarik Gheit; Dana Holzinger; Marco Petrillo; Davide Rizzo; Gianluigi Petrone; Francesco Miccichè; Gian Carlo Mattiucci; Damiano Arciuolo; Giampiero Capobianco; Giovanni Delogu; Vincenzo Valentini; Massimo Tommasino; Francesco Bussu Journal: Vaccines (Basel) Date: 2022-01-27
Authors: Daniel R Dickstein; Marc Egerman; Erica Monrose; Achintya Varma; Umut Ozbek; Sonam Sharma; Jerry T Liu; Vishal Gupta; Marshall R Posner; Krzysztof Misiukiewicz; Brett A Miles; Eric Genden; Richard L Bakst Journal: Head Neck Date: 2020-12-08 Impact factor: 3.821