Lianqiang Che1,2, Liang Hu3,4, Qiang Zhou3,4, Xie Peng3,4, Yang Liu3,4, Yuheng Luo3,4, Zhengfeng Fang3,4, Yan Lin3,4, Shengyu Xu3,4, Bin Feng3,4, Jian Li3,4, Jiayong Tang3,4. 1. Institute of Animal Nutrition, Sichuan Agricultural University, Ya'an, Sichuan, China. clianqiang@hotmail.com. 2. Key Laboratory for Animal Disease-Resistance Nutrition, Ministry of Education, Ya'an, Sichuan, China. clianqiang@hotmail.com. 3. Institute of Animal Nutrition, Sichuan Agricultural University, Ya'an, Sichuan, China. 4. Key Laboratory for Animal Disease-Resistance Nutrition, Ministry of Education, Ya'an, Sichuan, China.
Abstract
PURPOSE: Dietary protein, as important macronutrient, is vital for intestinal function and health status. We aimed to determine the effects of dietary protein source on growth performance and intestinal function of neonates with intrauterine growth retardation (IUGR) in a pig model. METHODS: Eighteen pairs of IUGR and normal birth weight (NBW) weaned pigs were allotted to be fed starter diet containing soybean protein concentrate (SPC) or spray-dried porcine plasma (SDPP) for 2 weeks. Growth performance, antioxidant variables, intestinal morphology and absorption capability, microbiota composition and short-chain fatty acids (SCFA) were assessed. RESULTS: IUGR led to poor growth performance, absorption capability and changes on antioxidant variables, while SDPP diet improved the growth performance, diarrhea index, intestinal morphology and antioxidant variables of IUGR or NBW pigs relative to that fed SPC diet. Importantly, SDPP diet improved bacterial diversity and increased the abundance of phylum Firmicutes, but decreased the phylum Proteobacteria in colonic digesta, associating with higher genera Lactobacillus and lower genera Escherichia-Shigella, linking to the increased concentration of SCFA. CONCLUSIONS: Our findings indicate that IUGR impairs the growth rate, intestinal function and oxidative status of weaned pigs, which could be partly improved by SDPP diet either for IUGR or NBW pigs, associating with the better antioxidant capability, composition of microbiotas and their metabolites.
PURPOSE: Dietary protein, as important macronutrient, is vital for intestinal function and health status. We aimed to determine the effects of dietary protein source on growth performance and intestinal function of neonates with intrauterine growth retardation (IUGR) in a pig model. METHODS: Eighteen pairs of IUGR and normal birth weight (NBW) weaned pigs were allotted to be fed starter diet containing soybean protein concentrate (SPC) or spray-dried porcine plasma (SDPP) for 2 weeks. Growth performance, antioxidant variables, intestinal morphology and absorption capability, microbiota composition and short-chain fatty acids (SCFA) were assessed. RESULTS: IUGR led to poor growth performance, absorption capability and changes on antioxidant variables, while SDPP diet improved the growth performance, diarrhea index, intestinal morphology and antioxidant variables of IUGR or NBW pigs relative to that fed SPC diet. Importantly, SDPP diet improved bacterial diversity and increased the abundance of phylum Firmicutes, but decreased the phylum Proteobacteria in colonic digesta, associating with higher genera Lactobacillus and lower genera Escherichia-Shigella, linking to the increased concentration of SCFA. CONCLUSIONS: Our findings indicate that IUGR impairs the growth rate, intestinal function and oxidative status of weaned pigs, which could be partly improved by SDPP diet either for IUGR or NBW pigs, associating with the better antioxidant capability, composition of microbiotas and their metabolites.
Entities:
Keywords:
Bacteria; Low birth weight; Oxidative stress; Pig; Protein source
Authors: Karolina Ferenc; Piotr Pietrzak; Michał M Godlewski; Jan Piwowarski; Robert Kiliańczyk; Paul Guilloteau; Romuald Zabielski Journal: Reprod Biol Date: 2014-01-30 Impact factor: 2.376
Authors: Chris J Hedegaard; Mikael L Strube; Marie B Hansen; Bodil K Lindved; Allan Lihme; Mette Boye; Peter M H Heegaard Journal: PLoS One Date: 2016-01-29 Impact factor: 3.240