M Carceller-Sindreu1, M Serra-Blasco2, J de Diego-Adeliño1, Y Vives-Gilabert3, M Vicent-Gil4, E Via5, D Puigdemont1, E Álvarez1, V Pérez6, M J Portella1. 1. Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Institut d'Investigació Biomèdica Sant Pau (IIB-Sant Pau), Universitat Autònoma de Barcelona (UAB), Spain. 2. Mental Health, Parc Taulí Sabadell-CIBERSAM, University Hospital, Sabadell, Barcelona, Spain. Electronic address: mserrab@tauli.cat. 3. Instituto ITACA, Universitat Politècnica de València (UPV), València, Spain. 4. Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Institut d'Investigació Biomèdica Sant Pau (IIB-Sant Pau), Universitat Autònoma de Barcelona (UAB), Spain; Mental Health, Parc Taulí Sabadell-CIBERSAM, University Hospital, Sabadell, Barcelona, Spain. 5. Mental Health, Parc Taulí Sabadell-CIBERSAM, University Hospital, Sabadell, Barcelona, Spain. 6. Hospital del Mar, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Universitat Autònoma de Barcelona (UAB), Spain.
Abstract
BACKGROUND: Major depressive disorder (MDD) is accompanied by atypical brain structure affecting grey and white matter from the early stages. Neuroimaging studies of first-episode depression (FED) have provided evidence on this regard, but most of the studies are cross-sectional. The aim of this longitudinal study was to test potential changes in grey matter (GM) and white matter (WM) volumes in FED. METHODS: Thirty-three untreated FED patients (DSM-IV criteria) and 33 healthy controls (HC) underwent a 3T structural magnetic resonance imaging (sMRI) at baseline and after 2 years. Depressive symptoms were assessed at baseline and throughout the study with the 17-item Hamilton Depressive Rating Scale (HDRS-17). Recurrences of FED patients were also collected along the follow-up. To analyze GM and WM differences, whole-brain voxel-based morphometry (VBM, SPM12) was employed (FWE corrected). RESULTS: FED patients showed significant reductions compared to HC in WM volumes of prefrontal cortex (left anterior corona radiata). No differences were found in GM volumes. Full factorial longitudinal analysis of the whole sample revealed no significant effect in GM nor in WM, while the full factorial longitudinal analysis comparing recurrent and non-recurrent patients showed increments in WM volumes of left posterior corona radiata and right posterior thalamic radiation in the recurrent group. LIMITATIONS: Limited sample size, especially in the follow-up. CONCLUSIONS: The present findings provided some new evidence of the role of white matter alterations in the early stages of MDD and in the progression of the illness.
BACKGROUND: Major depressive disorder (MDD) is accompanied by atypical brain structure affecting grey and white matter from the early stages. Neuroimaging studies of first-episode depression (FED) have provided evidence on this regard, but most of the studies are cross-sectional. The aim of this longitudinal study was to test potential changes in grey matter (GM) and white matter (WM) volumes in FED. METHODS: Thirty-three untreated FEDpatients (DSM-IV criteria) and 33 healthy controls (HC) underwent a 3T structural magnetic resonance imaging (sMRI) at baseline and after 2 years. Depressive symptoms were assessed at baseline and throughout the study with the 17-item Hamilton Depressive Rating Scale (HDRS-17). Recurrences of FEDpatients were also collected along the follow-up. To analyze GM and WM differences, whole-brain voxel-based morphometry (VBM, SPM12) was employed (FWE corrected). RESULTS:FEDpatients showed significant reductions compared to HC in WM volumes of prefrontal cortex (left anterior corona radiata). No differences were found in GM volumes. Full factorial longitudinal analysis of the whole sample revealed no significant effect in GM nor in WM, while the full factorial longitudinal analysis comparing recurrent and non-recurrent patients showed increments in WM volumes of left posterior corona radiata and right posterior thalamic radiation in the recurrent group. LIMITATIONS: Limited sample size, especially in the follow-up. CONCLUSIONS: The present findings provided some new evidence of the role of white matter alterations in the early stages of MDD and in the progression of the illness.
Authors: Devyn L Cotter; Samantha M Walters; Corrina Fonseca; Amy Wolf; Yann Cobigo; Emily C Fox; Michelle Y You; Marie Altendahl; Nina Djukic; Adam M Staffaroni; Fanny M Elahi; Joel H Kramer; Kaitlin B Casaletto Journal: Am J Geriatr Psychiatry Date: 2020-05-15 Impact factor: 4.105
Authors: Hannah Lemke; Hannah Klute; Jennifer Skupski; Katharina Thiel; Lena Waltemate; Alexandra Winter; Fabian Breuer; Susanne Meinert; Melissa Klug; Verena Enneking; Nils R Winter; Dominik Grotegerd; Elisabeth J Leehr; Jonathan Repple; Katharina Dohm; Nils Opel; Frederike Stein; Tina Meller; Katharina Brosch; Kai G Ringwald; Julia-Katharina Pfarr; Florian Thomas-Odenthal; Tim Hahn; Axel Krug; Andreas Jansen; Walter Heindel; Igor Nenadić; Tilo Kircher; Udo Dannlowski Journal: Transl Psychiatry Date: 2022-08-27 Impact factor: 7.989