Erika Hurtado-Salgado1, Eduardo Ortiz-Panozo1, Jorge Salmerón2, Nenetzen Saavedra-Lara3, Pablo Kuri-Morales4, Eduardo Pesqueira-Villegas5, Rufino Luna-Gordillo5, Eduardo L Franco6, Eduardo Lazcano-Ponce1. 1. Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública. Cuernavaca, México. 2. Facultad de Medicina, Universidad Nacional Autónoma de México. Ciudad de México, México. 3. Centro de Información para Decisiones en Salud Pública, Instituto Nacional de Salud Pública. Cuernavaca, México. 4. Subsecretaría de Prevención y Promoción de la Salud, Secretaría de Salud. Ciudad de México, México. 5. Centro Nacional de Equidad de Género y Salud Reproductiva, Secretaría de Salud. Ciudad de México, México. 6. Division of Cancer Epidemiology, McGill University. Montreal, Canadá.
Abstract
OBJECTIVE: To describe the methods of a study aimed at evaluating high risk-HPV (hrHPV)-based screening and cervical cytology as triage compared to conventional cervical cytology as primary screening in the detection of grade 2+ cervical intraepithelial neoplasia in the National Cancer Screening Program (NCSP) of Mexico. MATERIALS AND METHODS: We will use information originated from the Womens Cancer Information System of Mexico regarding cervical cancer from 2008 to 2018. The database includes cytology results, diagnostic confirmation by histopathology and/or treatment colposcopy. We will then carry out statistical analyses on approximately 15 million hrHPV. RESULTS: We will evaluate the overall performance of hrHPV-based screening as part of the NCSP and compare hrHPV-based to cytology-based screening under real-life conditions. To guarantee an unbiased comparison between hrHPV with cytology triage and conventional cytology we will use propensity score matching. CONCLUSIONS: ytology we will use propensity score matching. Conclusion. Decision makers may use our results to identify areas of opportunity for improvement in NCSP processe.
OBJECTIVE: To describe the methods of a study aimed at evaluating high risk-HPV (hrHPV)-based screening and cervical cytology as triage compared to conventional cervical cytology as primary screening in the detection of grade 2+ cervical intraepithelial neoplasia in the National Cancer Screening Program (NCSP) of Mexico. MATERIALS AND METHODS: We will use information originated from the Womens Cancer Information System of Mexico regarding cervical cancer from 2008 to 2018. The database includes cytology results, diagnostic confirmation by histopathology and/or treatment colposcopy. We will then carry out statistical analyses on approximately 15 million hrHPV. RESULTS: We will evaluate the overall performance of hrHPV-based screening as part of the NCSP and compare hrHPV-based to cytology-based screening under real-life conditions. To guarantee an unbiased comparison between hrHPV with cytology triage and conventional cytology we will use propensity score matching. CONCLUSIONS: ytology we will use propensity score matching. Conclusion. Decision makers may use our results to identify areas of opportunity for improvement in NCSP processe.
Entities:
Keywords:
DNA probes; HPV; Mexico; cervical intraepithelial neoplasia; cervical smears; health informations systems
Authors: Juan Ramón Padilla-Mendoza; Lucía Angélica Gómez-López; Mavil López-Casamichana; Elisa Irene Azuara-Liceaga; Enoc Mariano Cortés-Malagón; Lilia López-Cánovas; Octavio Daniel Reyes-Hernández; Mario Alberto Rodríguez; José Bonilla-Delgado; Israel López-Reyes Journal: Biomed Res Int Date: 2020-11-13 Impact factor: 3.411
Authors: Mariel A Oyervides-Muñoz; Antonio A Pérez-Maya; Celia N Sánchez-Domínguez; Anais Berlanga-Garza; Mauro Antonio-Macedo; Lezmes D Valdéz-Chapa; Ricardo M Cerda-Flores; Victor Trevino; Hugo A Barrera-Saldaña; María L Garza-Rodríguez Journal: Viruses Date: 2020-03-31 Impact factor: 5.048